Search Results - "Chan, Grace K"

Spatial activation of ezrin by epidermal growth factor receptor and focal adhesion kinase co-ordinates epithelial cell migration by Chan, Grace K, McGrath, John A, Parsons, Maddy

“…Epidermal growth factor receptor (EGFR) plays a critical role in the promotion of epithelial cell proliferation and migration. Previous studies have suggested…”
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MK-2461, a Novel Multitargeted Kinase Inhibitor, Preferentially Inhibits the Activated c-Met Receptor by PAN, Bo-Sheng, CHAN, Grace K. Y, JEWELL, James P, KARIV, Ilona, KATZ, Jason D, KUNII, Kaiko, WEI LU, LUTTERBACH, Bart A, PAWELETZ, Cloud P, XIANLU QU, REILLY, John F, SZEWCZAK, Alexander A, CHENARD, Melissa, QINWEN ZENG, KOHL, Nancy E, DINSMORE, Christopher J, CHI, An, DAVIS, Lenora J, DESHMUKH, Sujal V, GIBBS, Jackson B, GIL, Susana, GAOZHEN HANG, HATCH, Harold

“…The receptor tyrosine kinase c-Met is an attractive target for therapeutic blockade in cancer. Here, we describe MK-2461, a novel ATP-competitive multitargeted…”
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Slac2-b Coordinates Extracellular Vesicle Secretion to Regulate Keratinocyte Adhesion and Migration by Bare, Yonis, Chan, Grace K., Hayday, Thomas, McGrath, John A., Parsons, Maddy

“…Slac2-b, also known as exophilin-5, is a Rab27b effector protein with a role in exosome transport and is encoded by the EXPH5 gene. We previously described…”
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Kindlin-1 Regulates Epidermal Growth Factor Receptor Signaling by Michael, Magdalene, Begum, Rumena, Chan, Grace K., Whitewood, Austin J., Matthews, Daniel R., Goult, Benjamin T., McGrath, John A., Parsons, Maddy

“…Kindler syndrome is an autosomal recessive genodermatosis that results from mutations in the FERMT1 gene encoding t kindlin-1. Kindlin-1 localizes to focal…”
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Multifocal multiphoton volumetric imaging approach for high-speed time-resolved Förster resonance energy transfer imaging in vivo by Poland, Simon P, Chan, Grace K, Levitt, James A, Krstajić, Nikola, Erdogan, Ahmet T, Henderson, Robert K, Parsons, Maddy, Ameer-Beg, Simon M

“…In this Letter, we will discuss the development of a multifocal multiphoton fluorescent lifetime imaging system where four individual fluorescent intensity and…”
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High-throughput analysis of HGF-stimulated cell scattering by Chan, Grace K Y, Lutterbach, Bart A, Pan, Bo-Sheng, Kariv, Ilona, Szewczak, Alexander A

“…Historically, only relatively low-throughput or expensive methods have been available to measure cell migration. Hepatocyte growth factor (HGF) is a ligand for…”
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Suppression of Coke Formation in the Steam Cracking of Alkanes:  Ethane and Propane by Grace Chan, K. Y, Inal, Fikret, Senkan, Selim

“…The effects of a H2PtCl6 additive on the rate of formation of coke deposits on quartz and Incoloy surfaces were investigated in the steam cracking of ethane…”
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A morphology- and kinetics-based cascade for human neural cell high content screening by Richards, Gillian R, Smith, Alison J, Parry, Frances, Platts, Amy, Chan, Grace K Y, Leveridge, Mathew, Kerby, Julie E, Simpson, Peter B

“…The prospect of manipulating endogenous neural stem cells to replace damaged tissue and correct functional deficits represents a novel mechanism for treating a…”
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Automated cell plating and sample treatments for fixed cells in high content assays by Richards, Gillian R, Kerby, Julie E, Chan, Grace K Y, Simpson, Peter B

“…Robust and reliable methods for the manipulation of neural cell lines, by passaging, plating, dye labeling, imaging, fixation, and immunocytochemistry, are…”
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High content kinetic assays of neuronal signaling implemented on BD pathway HT by Chan, Grace K Y, Richards, Gillian R, Peters, Marco, Simpson, Peter B

“…A great deal of information can be gained from kinetic fluorescence-based measurement of cellular responses; however, until recently the use of such approaches…”
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The role of interferon-β in the attenuation of cardiac fibrosis in coxsackievirus B3-induced myocarditis by Chan, Grace K. Y

“…Interferon-β has previously been shown to decrease the development of pathological fibrosis in various profibrotic diseases. Viral myocarditis leading to…”
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The role of interferon-beta in the attenuation of cardiac fibrosis in coxsackievirus B3-induced myocarditis by Chan, Grace K. Y

“…Interferon-beta has previously been shown to decrease the development of pathological fibrosis in various profibrotic diseases. Viral myocarditis leading to…”
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Implementation of a High Specification Dual-Arm Robotic Platform to Meet Flexible Screening Needs by Moore, Kevin W., Newman, Robert, Chan, Grace K.Y., Leech, Clare, Allison, Karen, Coulson, Jo, Simpson, Peter B.

“…The need for a high degree of flexibility within compound screening is a requirement throughout the drug discovery industry. The demands made of automation…”
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China by Chan, Grace K W

“…Since the People's Republic of China (PRC) opened up to foreign trade in 1978, it has promulgated a series of laws and regulations to complement its economic…”
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