Search Results - "Chan, Gloria G"

Blood Proteomic Profiling in Inherited (ATTRm) and Acquired (ATTRwt) Forms of Transthyretin-Associated Cardiac Amyloidosis by Chan, Gloria G, Koch, Clarissa M, Connors, Lawreen H

“…Transthyretin-associated forms of cardiac amyloidosis are fatal protein misfolding diseases that can be inherited (ATTRm) or acquired (ATTRwt). An accurate…”
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MYD88 mutated and wild-type Waldenström's Macroglobulinemia: characterization of chromosome 6q gene losses and their mutual exclusivity with mutations in CXCR4 by Guerrera, Maria Luisa, Tsakmaklis, Nickolas, Xu, Lian, Yang, Guang, Demos, Maria, Kofides, Amanda, Chan, Gloria G, Manning, Robert J, Liu, Xia, Chen, Jiaji G, Munshi, Manit, Patterson, Christopher J, Castillo, Jorge J, Dubeau, Toni, Gustine, Joshua, Carrasco, Ruben D, Arcaini, Luca, Varettoni, Marzia, Cazzola, Mario, Treon, Steven P, Hunter, Zachary R

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Identification of Transthyretin Cardiac Amyloidosis Using Serum Retinol-Binding Protein 4 and a Clinical Prediction Model by Arvanitis, Marios, Koch, Clarissa M, Chan, Gloria G, Torres-Arancivia, Celia, LaValley, Michael P, Jacobson, Daniel R, Berk, John L, Connors, Lawreen H, Ruberg, Frederick L

“…Transthyretin cardiac amyloidosis (ATTR) is an underrecognized cause of heart failure (HF) in older individuals, owing in part to difficulty in diagnosis. ATTR…”
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Expression of the prosurvival kinase HCK requires PAX5 and mutated MYD88 signaling in MYD88-driven B-cell lymphomas by Liu, Xia, Chen, Jiaji G., Munshi, Manit, Hunter, Zachary R., Xu, Lian, Kofides, Amanda, Tsakmaklis, Nickolas, Demos, Maria G., Guerrera, Maria Luisa, Chan, Gloria G., Jimenez, Cristina, Patterson, Christopher J., Meid, Kirsten, Keezer, Andrew, Castillo, Jorge J., Treon, Steven P., Yang, Guang

“…Hematopoietic cell kinase (HCK) is an SRC family member that is aberrantly upregulated in B-cell neoplasms dependent on MYD88-activating mutations and supports…”
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CXCR4 mutation subtypes impact response and survival outcomes in patients with Waldenström macroglobulinaemia treated with ibrutinib by Castillo, Jorge J., Xu, Lian, Gustine, Joshua N., Keezer, Andrew, Meid, Kirsten, Dubeau, Toni E., Liu, Xia, Demos, Maria G., Kofides, Amanda, Tsakmaklis, Nicholas, Chen, Jiaji G., Munshi, Manit, Guerrera, Maria L., Chan, Gloria G., Patterson, Christopher J., Yang, Guang, Hunter, Zachary R., Treon, Steven P.

“…Summary Ibrutinib is associated with response rate of 90% and median progression‐free survival (PFS) in excess of 5 years in Waldenström macroglobulinaemia…”
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CXCR4 S338X clonality is an important determinant of ibrutinib outcomes in patients with Waldenström macroglobulinemia by Gustine, Joshua N, Xu, Lian, Tsakmaklis, Nicholas, Demos, Maria G, Kofides, Amanda, Chen, Jiaji G, Liu, Xia, Munshi, Manit, Guerrera, Maria Luisa, Chan, Gloria G, Patterson, Christopher J, Keezer, Andrew, Meid, Kirsten, Dubeau, Toni, Yang, Guang, Hunter, Zachary R, Treon, Steven P, Castillo, Jorge J

“…Key Points CXCR4 S338X clonality ≥25% is associated with lower very good partial response and shorter progression-free survival to ibrutinib. CXCR4 S338X…”
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BTKCys481Ser drives ibrutinib resistance via ERK1/2 and protects BTKwild-type MYD88-mutated cells by a paracrine mechanism by Chen, Jiaji G., Liu, Xia, Munshi, Manit, Xu, Lian, Tsakmaklis, Nicholas, Demos, Maria G., Kofides, Amanda, Guerrera, Maria Luisa, Chan, Gloria G., Patterson, Christopher J., Meid, Kirsten, Gustine, Joshua, Dubeau, Toni, Severns, Patricia, Castillo, Jorge J., Hunter, Zachary R., Wang, Jinhua, Buhrlage, Sara J., Gray, Nathanael S., Treon, Steven P., Yang, Guang

“…Acquired ibrutinib resistance due to BTKCys481 mutations occurs in B-cell malignancies, including those with MYD88 mutations. BTKCys481 mutations are usually…”
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Genomic evolution of ibrutinib‐resistant clones in Waldenström macroglobulinaemia by Jiménez, Cristina, Chan, Gloria G., Xu, Lian, Tsakmaklis, Nickolas, Kofides, Amanda, Demos, Maria G., Chen, Jiaji, Liu, Xia, Munshi, Manit, Yang, Guang, Castillo, Jorge J., Wiestner, Adrian, García‐Sanz, Ramón, Treon, Steven P., Hunter, Zachary R.

“…Summary Ibrutinib is highly active in Waldenström macroglobulinaemia (WM) patients, but disease progression can occur due to acquired mutations in BTK, the…”
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TP53 mutations are associated with mutated MYD88 and CXCR4, and confer an adverse outcome in Waldenström macroglobulinaemia by Gustine, Joshua N., Tsakmaklis, Nicholas, Demos, Maria G., Kofides, Amanda, Chen, Jiaji G., Liu, Xia, Munshi, Manit, Guerrera, Maria L., Chan, Gloria G., Patterson, Christopher J., Meid, Kirsten, Dubeau, Toni, Yang, Guang, Hunter, Zachary R., Treon, Steven P., Castillo, Jorge J., Xu, Lian

“…Summary Little is known about TP53 mutations in Waldenström Macroglobulinaemia (WM). We evaluated 265 WM patients for TP53 mutations by next‐generation…”
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Serum Proteomic Variability Associated with Clinical Phenotype in Familial Transthyretin Amyloidosis (ATTRm) by Chan, Gloria G, Koch, Clarissa M, Connors, Lawreen H

“…Transthyretin (TTR), normally a plasma circulating protein, can become misfolded and aggregated, ultimately leading to extracellular deposition of amyloid…”
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Insights into the genomic landscape of MYD88 wild-type Waldenström macroglobulinemia by Hunter, Zachary R., Xu, Lian, Tsakmaklis, Nickolas, Demos, Maria G., Kofides, Amanda, Jimenez, Cristina, Chan, Gloria G., Chen, Jiaji, Liu, Xia, Munshi, Manit, Gustine, Joshua, Meid, Kirsten, Patterson, Christopher J., Yang, Guang, Dubeau, Toni, Samur, Mehmet K., Castillo, Jorge J., Anderson, Kenneth C., Munshi, Nikhil C., Treon, Steven P.

“…Activating MYD88 mutations are present in 95% of Waldenström macroglobulinemia (WM) patients, and trigger NF-κB through BTK and IRAK. The BTK inhibitor…”
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SYK is activated by mutated MYD88 and drives pro-survival signaling in MYD88 driven B-cell lymphomas by Munshi, Manit, Liu, Xia, Chen, Jiaji G., Xu, Lian, Tsakmaklis, Nickolas, Demos, Maria G., Kofides, Amanda, Guerrera, Maria Luisa, Jimenez, Cristina, Chan, Gloria G., Hunter, Zachary R., Palomba, M. Lia, Argyropoulos, Kimon V., Meid, Kirsten, Keezer, Andrew, Gustine, Joshua, Dubeau, Toni, Castillo, Jorge J., Patterson, Christopher J., Wang, Jinhua, Buhrlage, Sara J., Gray, Nathanael S., Treon, Steven P., Yang, Guang

“…Activating MYD88 mutations promote pro-survival signaling through BTK and HCK, both targets of ibrutinib. Despite high response rates, complete responses to…”
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Prevalence of mutant ATTR cardiac amyloidosis in elderly African Americans with heart failure by Arvanitis, Marios, Chan, Gloria G., Jacobson, Daniel R., Berk, John L., Connors, Lawreen H., Ruberg, Frederick L.

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Genetic variation of the transthyretin gene in wild-type transthyretin amyloidosis (ATTRwt) by Sikora, Jacquelyn L., Logue, Mark W., Chan, Gloria G., Spencer, Brian H., Prokaeva, Tatiana B., Baldwin, Clinton T., Seldin, David C., Connors, Lawreen H.

“…Wild-type transthyretin amyloidosis (ATTRwt), typically diagnosed as congestive heart failure in elderly Caucasian men, features myocardial amyloid deposits of…”
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Comparative genomics of CXCR4MUT and CXCR4WT single cells in Waldenström's macroglobulinemia by Jiménez, Cristina, Xu, Lian, Tsakmaklis, Nickolas, Demos, Maria G., Kofides, Amanda, Chan, Gloria G., Guerrera, Maria Luisa, Chen, Jiaji G., Liu, Xia, Munshi, Manit, Patterson, Christopher J., Yang, Guang, Castillo, Jorge J., Treon, Steven P., Hunter, Zachary R.

“…•Single-cell whole-genome amplification can be used to interrogate the genomic architecture of Waldenström's macroglobulinemia.•The mutational signature of…”
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CXCR4 Mutational Status Does Not Impact Outcomes in Patients with Waldenstrom Macroglobulinemia Treated with Proteasome Inhibitors by Castillo, Jorge J., Gustine, Joshua, Demos, Maria, Keezer, Andrew, Meid, Kirsten, Dubeau, Toni, Chan, Gloria G, Chen, Jiaji, Guerrera, Maria Luisa, Kofides, Amanda, Munshi, Manit, Tsakmaklis, Nicholas, Liu, Xia, Xu, Lian, Yang, Guang, Hunter, Zachary R, Treon, Steven P

“…Introduction: Approximately 40% of patients with Waldenström macroglobulinemia (WM) have an activating somatic mutation in CXCR4, including both nonsense and…”
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Mutated MYD88 Regulates HCK Pro-Survival Signaling through JunB in MYD88 Mutated B-Lymphoma Cells by Liu, Xia, Chen, Jiaji G, Munshi, Manit, Xu, Lian, Kofides, Amanda, Tsakmaklis, Nicholas, Demos, Maria, Guerrera, Maria Luisa, Chan, Gloria G, Jimenez, Cristina, Hunter, Zachary R, Patterson, Christopher, Meid, Kirsten, Keezer, Andrew, Castillo, Jorge J., Treon, Steven P, Yang, Guang

“…Hematopoietic cell kinase (HCK) is a member of the SRC family tyrosine kinases (SFKs) that is down-regulated in later stages of B-cell ontogeny. In MYD88…”
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Clinical and Genomic Factors Are Predictive of Response and Prognostic of Progression-Free Survival in Patients with Waldenström Macroglobulinemia Treated with Ibrutinib by Castillo, Jorge J., Gustine, Joshua, Demos, Maria, Keezer, Andrew, Meid, Kirsten, Chan, Gloria G, Chen, Jiaji G, Guerrera, Maria Luisa, Kofides, Amanda, Munshi, Manit, Tsakmaklis, Nicholas, Liu, Xia, Xu, Lian, Yang, Guang, Hunter, Zachary R, Treon, Steven P

“…Introduction: The Bruton tyrosine kinase inhibitor ibrutinib is the only FDA approved therapy for the treatment of symptomatic Waldenstrom macroglobulinemia…”
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Genomic Evolution of Ibrutinib Resistant Clones in Waldenström Macroglobulinemia by Jiménez, Cristina, Chan, Gloria G., Xu, Lian, Tsakmaklis, Nickolas, Kofides, Amanda, Demos, Maria G., Chen, Jiaji, Liu, Xia, Munshi, Manit, Yang, Guang, Castillo, Jorge J., Wiestner, Adrian, García- Sanz, Ramón, Treon, Steven P., Hunter, Zachary R.

“…Ibrutinib is highly active in Waldenström macroglobulinemia (WM) patients, but disease progression can occur due to acquired mutations in BTK, the target of…”
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Comprehensive Integration of Whole Genome, Transcriptome and Methylation Profiling Reveals Novel Gene Dysregulation Including IL15, SOCS6 and CARD11 Associated with MYD88 and CXCR4 Genotype Status in WM by Hunter, Zachary R, Chan, Gloria G, Jimenez, Cristina, Tsakmaklis, Nickolas, Xu, Lian, Chen, Jiaji G, Demos, Maria, Kofides, Amanda, Munshi, Manit, Guerrera, Maria Luisa, Liu, Xia, Yang, Guang, Castillo, Jorge J., Melnick, Ari M, Treon, Steven P

“…Background: Waldenstrom's Macroglobulinemia/IgM lyphoplasmacytic lymphoma is a B-cell lymphoma defined by highly recurring mutations in MYD88 (95-97%) and…”
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