Search Results - "Chan, George H.M."

Doping control analysis of 46 polar drugs in horse plasma and urine using a ‘dilute-and-shoot’ ultra high performance liquid chromatography-high resolution mass spectrometry approach by Kwok, Wai Him, Choi, Timmy L.S., Kwok, Karen Y., Chan, George H.M., Wong, Jenny K.Y., Wan, Terence S.M.

“…•Two ‘dilute-and-shoot’ UHPLC-HRMS methods for equine urine and plasma are developed.•These methods can detect 46 polar drugs in equine urine and plasma.•The…”
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Simultaneous detection of recombinant growth hormones in equine plasma by liquid chromatography/high-resolution tandem mass spectrometry for doping control by Wong, Kin-Sing, Chan, George H.M., Ho, Emmie N.M., Wan, Terence S.M.

“…•First report of a simultaneous detection of multiple recombinant GHs by LC–MSMS.•A sensitive (at low ng/mL level) detection method for different recombinant…”
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Unravelling androgens in sport: Altrenogest shows strong activation of the androgen receptor in a mammalian cell bioassay by Gillon, Ashley, Ho, Emmie N.M., Chan, George H.M., Kauff, Alexia, Hughes, Gillian, Lund, Rachel A., Ashley, Zoe, Wan, Terence S.M., Heather, Alison K.

“…Altrenogest is a commonly used progestogen for the suppression of oestrus and associated distracting behaviours that interfere with training and performance of…”
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Doping control analysis of total arsenic in equine plasma by Chan, George H.M., Tang, Wenlu, Curl, Peter, Lin, Yuanyuan, Wan, Terence S.M., Ho, Emmie N.M.

“…Arsenic can be easily found in our surrounding environment. Because of its ubiquitous nature, horse urine and blood invariably contain low levels of arsenic…”
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A high‐throughput and broad‐spectrum screening method for analysing over 120 drugs in horse urine using liquid chromatography–high‐resolution mass spectrometry by Wong, Jenny K.Y., Chan, George H.M., Choi, Timmy L.S., Kwok, Karen Y., Lau, Ming Y., Leung, Gary N.W., Wan, Terence S.M., Ho, Emmie N.M.

“…A high‐throughput method has been developed for the doping control analysis of 124 drug targets, processing up to 154 horse urine samples in as short as 4.5 h,…”
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Controlling the misuse of cobalt in horses by Ho, Emmie N. M., Chan, George H. M., Wan, Terence S. M., Curl, Peter, Riggs, Christopher M., Hurley, Michael J., Sykes, David

“…Cobalt is a well‐established inducer of hypoxia‐like responses, which can cause gene modulation at the hypoxia inducible factor pathway to induce…”
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Interlaboratory trial for the measurement of total cobalt in equine urine and plasma by ICP‐MS by Popot, Marie‐Agnes, Ho, Emmie N.M., Stojiljkovic, Natali, Bagilet, Florian, Remy, Pierre, Maciejewski, Pascal, Loup, Benoit, Chan, George H.M., Hargrave, Sabine, Arthur, Rick M., Russo, Charlie, White, James, Hincks, Pamela, Pearce, Clive, Ganio, George, Zahra, Paul, Batty, David, Jarrett, Mark, Brooks, Lydia, Prescott, Lise‐Anne, Bailly‐Chouriberry, Ludovic, Bonnaire, Yves, Wan, Terence S.M.

“…Cobalt is an essential mineral micronutrient and is regularly present in equine nutritional and feed supplements. Therefore, cobalt is naturally present at low…”
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In vitro phase I metabolism of selective estrogen receptor modulators in horse using ultra‐high performance liquid chromatography‐high resolution mass spectrometry by Kwok, Karen Y., Chan, George H. M., Kwok, Wai Him, Wong, Jenny K. Y., Wan, Terence S. M.

“…Selective estrogen receptor modulators (SERMs) are chemicals that possess the anti‐oestrogenic activities that are banned ‘in’ and ‘out’ of competition by the…”
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Generation of phase II in vitro metabolites using homogenized horse liver by Wong, Jenny K. Y., Chan, George H. M., Leung, David K. K., Tang, Francis P. W., Wan, Terence S. M.

“…The successful use of homogenized horse liver for the generation of phase I in vitro metabolites has been previously reported by the authors’ laboratory. Prior…”
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Doping control study of AICAR in post‐race urine and plasma samples from horses by Wong, Jenny K. Y., Kwok, Wai Him, Chan, George H. M., Choi, Timmy L. S., Ho, Emmie N. M., Jaubert, Murielle, Bailly‐Chouriberry, Ludovic, Bonnaire, Yves, Cawley, Adam, Ming Williams, H., Keledjian, John, Brooks, Lydia, Chambers, Adam, Lin, Yuanyuan, Wan, Terence S. M.

“…Acadesine, 5‐aminoimidazole‐4‐carboxamide‐1‐β‐D‐ribofuranoside, commonly known as AICAR, is a naturally occurring adenosine monophosphate‐activated protein…”
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