Search Results - "Chan, Francis K."

Peptic ulcer disease by Lanas, Angel, Prof, Chan, Francis K L, MD

“…Summary The rapidly declining prevalence of Helicobacter pylori infection and widespread use of potent anti-secretory drugs means peptic ulcer disease has…”
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Current knowledge on non-steroidal anti-inflammatory drug-induced small-bowel damage: a comprehensive review by Watanabe, Toshio, Fujiwara, Yasuhiro, Chan, Francis K. L.

“…Recent advances in small-bowel endoscopy such as capsule endoscopy have shown that non-steroidal anti-inflammatory drugs (NSAIDs) frequently damage the small…”
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Gut microbiota in COVID-19: key microbial changes, potential mechanisms and clinical applications by Zhang, Fen, Lau, Raphaela I., Liu, Qin, Su, Qi, Chan, Francis K. L., Ng, Siew C.

“…The gastrointestinal tract is involved in coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The gut…”
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Peptic ulcer disease by Malfertheiner, Peter, Prof, Chan, Francis KL, MD, McColl, Kenneth EL, MD

“…Summary Peptic ulcer disease had a tremendous effect on morbidity and mortality until the last decades of the 20th century, when epidemiological trends started…”
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Multi-cohort analysis of colorectal cancer metagenome identified altered bacteria across populations and universal bacterial markers by Dai, Zhenwei, Coker, Olabisi Oluwabukola, Nakatsu, Geicho, Wu, William K K, Zhao, Liuyang, Chen, Zigui, Chan, Francis K L, Kristiansen, Karsten, Sung, Joseph J Y, Wong, Sunny Hei, Yu, Jun

“…Alterations of gut microbiota are associated with colorectal cancer (CRC) in different populations and several bacterial species were found to contribute to…”
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Challenges in the management of acute peptic ulcer bleeding by Lau, James YW, Prof, Barkun, Alan, Prof, Fan, Dai-ming, Prof, Kuipers, Ernst J, Prof, Yang, Yun-sheng, Prof, Chan, Francis KL, Prof

“…Summary Acute upper gastrointestinal bleeding is a common medical emergency worldwide, a major cause of which are bleeding peptic ulcers. Endoscopic treatment…”
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Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo by Polykratis, Apostolos, Hermance, Nicole, Zelic, Matija, Roderick, Justine, Kim, Chun, Van, Trieu-My, Lee, Thomas H, Chan, Francis K M, Pasparakis, Manolis, Kelliher, Michelle A

“…The serine/threonine kinase RIPK1 is recruited to TNFR1 to mediate proinflammatory signaling and to regulate TNF-induced cell death. A RIPK1 deficiency results…”
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Prevotella species in the human gut is primarily comprised of Prevotella copri, Prevotella stercorea and related lineages by Yeoh, Yun Kit, Sun, Yang, Ip, Lawrence Yuk Ting, Wang, Lan, Chan, Francis K. L., Miao, Yinglei, Ng, Siew C.

“…Prevotella species in the human gut microbiome are primarily comprised of Prevotella copri , and its diversity and function were recently investigated in…”
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Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trial by Chan, Francis KL, Prof, Lanas, Angel, Prof, Scheiman, James, Prof, Berger, Manuela F, MD, Nguyen, Ha, PhD, Goldstein, Jay L, Prof

“…Summary Background Cyclo-oxygenase (COX)-2-selective non-steroidal anti-inflammatory drugs (NSAIDs) and non-selective NSAIDs plus a proton-pump inhibitor (PPI)…”
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Gut microbiome dysbiosis across early Parkinson’s disease, REM sleep behavior disorder and their first-degree relatives by Huang, Bei, Chau, Steven W. H., Liu, Yaping, Chan, Joey W. Y., Wang, Jing, Ma, Suk Ling, Zhang, Jihui, Chan, Paul K. S., Yeoh, Yun Kit, Chen, Zigui, Zhou, Li, Wong, Sunny Hei, Mok, Vincent C. T., To, Ka Fai, Lai, Hei Ming, Ng, Simon, Trenkwalder, Claudia, Chan, Francis K. L., Wing, Yun Kwok

“…The microbiota-gut-brain axis has been suggested to play an important role in Parkinson’s disease (PD). Here we performed a cross-sectional study to profile…”
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Faecal microbiome-based machine learning for multi-class disease diagnosis by Su, Qi, Liu, Qin, Lau, Raphaela Iris, Zhang, Jingwan, Xu, Zhilu, Yeoh, Yun Kit, Leung, Thomas W. H., Tang, Whitney, Zhang, Lin, Liang, Jessie Q. Y., Yau, Yuk Kam, Zheng, Jiaying, Liu, Chengyu, Zhang, Mengjing, Cheung, Chun Pan, Ching, Jessica Y. L., Tun, Hein M., Yu, Jun, Chan, Francis K. L., Ng, Siew C.

“…Systemic characterisation of the human faecal microbiome provides the opportunity to develop non-invasive approaches in the diagnosis of a major human disease…”
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Gamma-glutamyltransferase 7 suppresses gastric cancer by cooperating with RAB7 to induce mitophagy by Wang, Xiaohong, Zhang, Lianhai, Chan, Francis K. L., Ji, Jiafu, Yu, Jun, Liang, Jessie Qiaoyi

“…We identified gamma-glutamyltransferase 7 ( GGT7 ) to be frequently downregulated in gastric cancer, but its role remains unknown. Here we elucidated the…”
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Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies by Ng, Siew C, Shi, Hai Yun, Hamidi, Nima, Underwood, Fox E, Tang, Whitney, Benchimol, Eric I, Panaccione, Remo, Ghosh, Subrata, Wu, Justin C Y, Chan, Francis K L, Sung, Joseph J Y, Kaplan, Gilaad G

“…Inflammatory bowel disease is a global disease in the 21st century. We aimed to assess the changing incidence and prevalence of inflammatory bowel disease…”
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Longitudinal dynamics of gut bacteriome, mycobiome and virome after fecal microbiota transplantation in graft-versus-host disease by Zhang, Fen, Zuo, Tao, Yeoh, Yun Kit, Cheng, Frankie W. T., Liu, Qin, Tang, Whitney, Cheung, Kitty C. Y., Yang, Keli, Cheung, Chun Pan, Mo, Chow Chung, Hui, Mamie, Chan, Francis K. L., Li, Chi-Kong, Chan, Paul K. S., Ng, Siew C.

“…Fecal microbiota transplant (FMT) has emerged as a potential treatment for severe colitis associated with graft-versus-host disease (GvHD) following…”
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Detection of miR-92a and miR-21 in stool samples as potential screening biomarkers for colorectal cancer and polyps by Wu, Chung Wah, Ng, Simon S M, Dong, Yu Juan, Ng, Siew Chien, Leung, Wing Wa, Lee, Chung Wa, Wong, Yee Ni, Chan, Francis K L, Yu, Jun, Sung, Joseph J Y

“…The detection of molecular markers in stool samples is a potential strategy for colorectal cancer (CRC) screening. This study evaluated the feasibility of…”
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Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production by Fortes, Guilherme B., Alves, Leticia S., de Oliveira, Rosane, Dutra, Fabianno F., Rodrigues, Danielle, Fernandez, Patricia L., Souto-Padron, Thais, De Rosa, María José, Kelliher, Michelle, Golenbock, Douglas, Chan, Francis K.M., Bozza, Marcelo T.

“…Diseases that cause hemolysis or myonecrosis lead to the leakage of large amounts of heme proteins. Free heme has proinflammatory and cytotoxic effects. Heme…”
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Peptostreptococcus anaerobius Induces Intracellular Cholesterol Biosynthesis in Colon Cells to Induce Proliferation and Causes Dysplasia in Mice by Tsoi, Ho, Chu, Eagle SH, Zhang, Xiang, Sheng, Jianqiu, Nakatsu, Daniel, Ng, Siew C, Chan, Anthony WH, Chan, Francis KL, Sung, Joseph JY, Yu, Jun

“…Abstract Background & Aims Stool samples from patients with colorectal cancer (CRC) have a higher abundance of Peptostreptococcus anaerobius than stool from…”
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Review article: Probiotics, prebiotics and dietary approaches during COVID-19 pandemic by Hu, Jielun, Zhang, Lin, Lin, Winnie, Tang, Whitney, Chan, Francis K.L., Ng, Siew C.

“…Patients with COVID-19 caused by SARS-CoV-2 exhibit diverse clinical manifestations and severity including enteric involvement. Commensal gut bacteria can…”
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Practice of endoscopy during COVID-19 pandemic: position statements of the Asian Pacific Society for Digestive Endoscopy (APSDE-COVID statements) by Chiu, Philip Wai Yan, Ng, Siew C, Inoue, Haruhiro, Reddy, D Nageshwar, Ling Hu, Enqiang, Cho, Joo Young, Ho, Lawrence Ky, Hewett, David G, Chiu, Han-Mo, Rerknimitr, Rungsun, Wang, Hsiu-Po, Ho, Shiaw Hooi, Seo, Dong Wan, Goh, Khean-Lee, Tajiri, Hisao, Kitano, Seigo, Chan, Francis K L

“…Coronavirus-19 (COVID-19) caused by SARS-CoV-2 has become a global pandemic. Risk of transmission may occur during endoscopy and the goal is to prevent…”
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Gut mucosal virome alterations in ulcerative colitis by Zuo, Tao, Lu, Xiao-Juan, Zhang, Yu, Cheung, Chun Pan, Lam, Siu, Zhang, Fen, Tang, Whitney, Ching, Jessica Y L, Zhao, Risheng, Chan, Paul K S, Sung, Joseph J Y, Yu, Jun, Chan, Francis K L, Cao, Qian, Sheng, Jian-Qiu, Ng, Siew C

“…The pathogenesis of UC relates to gut microbiota dysbiosis. We postulate that alterations in the viral community populating the intestinal mucosa play an…”
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