Search Results - "Chan, Edwin S L"

Ecto-5'-nucleotidase (CD73) -mediated extracellular adenosine production plays a critical role in hepatic fibrosis by Peng, Zhongsheng, Fernandez, Patricia, Wilder, Tuere, Yee, Herman, Chiriboga, Luis, Chan, Edwin S.L, Cronstein, Bruce N

“…Adenosine is a potent endogenous regulator of tissue repair that is released from injured cells and tissues. Hepatic fibrosis results from chronic hepatic…”
Get full text

Methotrexate-how does it really work? by Chan, Edwin S. L, Cronstein, Bruce N

“…Methotrexate is a proven and efficacious therapy for inflammatory diseases such as rheumatoid arthritis. The main mechanism of action of methotrexate as an…”
Get full text

Adenosine in fibrosis by Chan, Edwin S. L., Cronstein, Bruce N.

“…Adenosine is an endogenous autocoid that regulates a multitude of bodily functions. Its anti-inflammatory actions are well known to rheumatologists since it…”
Get full text

Adenosine A2A Receptor Blockade or Deletion Diminishes Fibrocyte Accumulation in the Skin in a Murine Model of Scleroderma, Bleomycin-induced Fibrosis by Katebi, Majid, Fernandez, Patricia, Chan, Edwin S. L., Cronstein, Bruce N.

“…Peripheral blood fibrocytes are a newly identified circulating leukocyte subpopulation that migrates into injured tissue where it may display fibroblast-like…”
Get full text

Cyclooxygenase-2-Derived E Prostaglandins Down-Regulate Matrix Metalloproteinase-1 Expression in Fibroblast-Like Synoviocytes via Inhibition of Extracellular Signal-Regulated Kinase Activation by Pillinger, Michael H, Rosenthal, Pamela B, Tolani, Sonia N, Apsel, Beth, Dinsell, Victoria, Greenberg, Jeffrey, Chan, Edwin S. L, Gomez, Paul F, Abramson, Steven B

“…We examined the regulation of matrix metalloproteinase (MMP) production by mitogen-activated protein kinases and cyclooxygenases (COXs) in fibroblast-like…”
Get full text

Pharmacological Blockade of A2A Receptors Prevents Dermal Fibrosis in a Model of Elevated Tissue Adenosine by Fernández, Patricia, Trzaska, Sean, Wilder, Tuere, Chiriboga, Luis, Blackburn, Michael R, Cronstein, Bruce N, Chan, Edwin S.L

“…Adenosine is a potent modulator of inflammation and tissue repair. We have recently reported that activation of adenosine A2A receptors promotes collagen…”
Get full text

Adenosine A2A receptor occupancy stimulates expression of proteins involved in reverse cholesterol transport and inhibits foam cell formation in macrophages by Reiss, Allison B., Rahman, Mohammad M., Chan, Edwin S. L., Montesinos, M. Carmen, Awadallah, Nahel W., Cronstein, Bruce N.

“…Transport of cholesterol out of macrophages is critical for prevention of foam cell formation, the first step in the pathogenesis of atherosclerosis. Proteins…”
Get full text

Mechanisms of action of methotrexate by Chan, Edwin S L, Cronstein, Bruce N

“…As one of the most utilized disease-modifying anti-rheumatic drugs, methotrexate (MTX) has revolutionized the treatment of rheumatoid arthritis as well as many…”
Get more information

Plasma from systemic lupus patients compromises cholesterol homeostasis: a potential mechanism linking autoimmunity to atherosclerotic cardiovascular disease by Reiss, Allison B., Anwar, Kamran, Merrill, Joan T., Chan, Edwin S. L., Awadallah, Nahel W., Cronstein, Bruce N., Michael Belmont, H., Belilos, Elise, Rosenblum, Gary, Belostocki, Kristina, Bonetti, Lois, Hasneen, Kowser, Carsons, Steven E.

“…Atherosclerotic cardiovascular disease (ASCVD) contributes to morbidity and mortality in systemic lupus erythematosus (SLE). Immunologic derangements may…”
Get full text

Effect of cyclooxygenase inhibition on cholesterol efflux proteins and atheromatous foam cell transformation in THP-1 human macrophages: a possible mechanism for increased cardiovascular risk by Chan, Edwin S L, Zhang, Hongwei, Fernandez, Patricia, Edelman, Sari D, Pillinger, Michael H, Ragolia, Louis, Palaia, Thomas, Carsons, Steven, Reiss, Allison B

“…Both selective cyclooxygenase (COX)-2 inhibitors and non-steroidal anti-inflammatory drugs (NSAIDs) have been beneficial pharmacological agents for many…”
Get full text

Adenosine A2A receptor occupancy stimulates collagen expression by hepatic stellate cells via pathways involving protein kinase A, Src, and extracellular signal-regulated kinases 1/2 signaling cascade or p38 mitogen-activated protein kinase signaling pathway by Che, Jiantu, Chan, Edwin S L, Cronstein, Bruce N

“…Prior studies indicate that adenosine and the adenosine A2A receptor play a role in hepatic fibrosis by a mechanism that has been proposed to involve direct…”
Get more information

Extracellular Generation of Adenosine by the Ectonucleotidases CD39 and CD73 Promotes Dermal Fibrosis by Fernández, Patricia, Perez-Aso, Miguel, Smith, Gideon, Wilder, Tuere, Trzaska, Sean, Chiriboga, Luis, Franks, Andrew, Robson, Simon C, Cronstein, Bruce N, Chan, Edwin S.L

“…Adenosine has an important role in inflammation and tissue remodeling and promotes dermal fibrosis by adenosine receptor (A2A R) activation. Adenosine may be…”
Get full text

Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis by Chan, Edwin S L, Montesinos, Maria Carmen, Fernandez, Patricia, Desai, Avani, Delano, David L, Yee, Herman, Reiss, Allison B, Pillinger, Michael H, Chen, Jiang-Fan, Schwarzschild, Michael A, Friedman, Scott L, Cronstein, Bruce N

“…1. Adenosine is a potent endogenous regulator of inflammation and tissue repair. Adenosine, which is released from injured and hypoxic tissue or in response to…”
Get full text

Adenosine A(2A) receptors promote collagen production by a Fli1- and CTGF-mediated mechanism by Chan, Edwin S L, Liu, Hailing, Fernandez, Patricia, Luna, Alex, Perez-Aso, Miguel, Bujor, Andreea M, Trojanowska, Maria, Cronstein, Bruce N

“…Adenosine, acting through the A(2A) receptor, promotes tissue matrix production in the skin and the liver and induces the development of dermal fibrosis and…”
Get full text

Adenosine A2A receptors play a role in the pathogenesis of hepatic cirrhosis by Chan, Edwin S L, Montesinos, Maria Carmen, Fernandez, Patricia, Desai, Avani, Delano, David L, Yee, Herman, Reiss, Allison B, Pillinger, Michael H, Chen, Jiang‐Fan, Schwarzschild, Michael A, Friedman, Scott L, Cronstein, Bruce N

“…1 Adenosine is a potent endogenous regulator of inflammation and tissue repair. Adenosine, which is released from injured and hypoxic tissue or in response to…”
Get full text

Methotrexate in Atherogenesis and Cholesterol Metabolism by Coomes, Eric, Chan, Edwin S. L., Reiss, Allison B.

“…Methotrexate is a disease-modifying antirheumatic drug commonly used to treat inflammatory conditions such as rheumatoid arthritis which itself is linked to…”
Get full text

Atheroprotective effects of methotrexate on reverse cholesterol transport proteins and foam cell transformation in human THP‐1 monocyte/macrophages by Reiss, Allison B., Carsons, Steven E., Anwar, Kamran, Rao, Soumya, Edelman, Sari D., Zhang, Hongwei, Fernandez, Patricia, Cronstein, Bruce N., Chan, Edwin S. L.

“…Objective To determine whether methotrexate (MTX) can overcome the atherogenic effects of cyclooxygenase 2 (COX‐2) inhibitors and interferon‐γ (IFNγ), both of…”
Get full text

Cholesterol in neurologic disorders of the elderly: stroke and Alzheimer’s disease by Reiss, Allison B, Siller, Keith A, Rahman, Mohammad M, Chan, Edwin S.L, Ghiso, Jorge, de Leon, Mony J

“…Mechanisms for the regulation of intracellular cholesterol levels in various types of brain and vascular cells are of considerable importance in our…”
Get full text

Molecular Pathogenesis of Skin Fibrosis: Insight from Animal Models by Smith, Gideon P., Chan, Edwin S. L.

“…Skin fibrosis occurs in a variety of human diseases, most notably systemic sclerosis (SSc). The end stage of scleroderma in human skin consists of excess…”
Get full text

Enhanced CD36 scavenger receptor expression in THP-1 human monocytes in the presence of lupus plasma: linking autoimmunity and atherosclerosis by Reiss, Allison B, Wan, David W, Anwar, Kamran, Merrill, Joan T, Wirkowski, Peter A, Shah, Nidhi, Cronstein, Bruce N, Chan, Edwin S L, Carsons, Steven E

“…Premature atherosclerotic cardiovascular disease (ASCVD) is a common and devastating complication of systemic lupus erythematosus (SLE). It is likely that…”
Get more information