Search Results - "Chan, Chris Chung Sing"

Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real‐time RT‐PCR assay targeting the 5′‐untranslated region of Zika virus by Chan, Jasper Fuk‐Woo, Yip, Cyril Chik‐Yan, Tee, Kah‐Meng, Zhu, Zheng, Tsang, Jessica Oi‐Ling, Chik, Kenn Ka‐Heng, Tsang, Terance Gi‐Wai, Chan, Chris Chung‐Sing, Poon, Vincent Kwok‐Man, Sridhar, Siddharth, Yin, Feifei, Hung, Ivan Fan‐Ngai, Chau, Sandy Ka‐Yee, Zhang, Anna Jinxia, Chan, Kwok‐Hung, Yuen, Kwok‐Yung

“…Objective and Method We developed and evaluated five novel real‐time RT‐PCR assays targeting conserved regions in the 5′‐untranslated region (5′‐UTR), envelope…”
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Simulation of the Clinical and Pathological Manifestations of Coronavirus Disease 2019 (COVID-19) in a Golden Syrian Hamster Model: Implications for Disease Pathogenesis and Transmissibility by Chan, Jasper Fuk-Woo, Zhang, Anna Jinxia, Yuan, Shuofeng, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Lee, Andrew Chak-Yiu, Chan, Wan-Mui, Fan, Zhimeng, Tsoi, Hoi-Wah, Wen, Lei, Liang, Ronghui, Cao, Jianli, Chen, Yanxia, Tang, Kaiming, Luo, Cuiting, Cai, Jian-Piao, Kok, Kin-Hang, Chu, Hin, Chan, Kwok-Hung, Sridhar, Siddharth, Chen, Zhiwei, Chen, Honglin, To, Kelvin Kai-Wang, Yuen, Kwok-Yung

“…Abstract Background A physiological small-animal model that resembles COVID-19 with low mortality is lacking. Methods Molecular docking on the binding between…”
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Surgical Mask Partition Reduces the Risk of Noncontact Transmission in a Golden Syrian Hamster Model for Coronavirus Disease 2019 (COVID-19) by Chan, Jasper Fuk-Woo, Yuan, Shuofeng, Zhang, Anna Jinxia, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Lee, Andrew Chak-Yiu, Fan, Zhimeng, Li, Can, Liang, Ronghui, Cao, Jianli, Tang, Kaiming, Luo, Cuiting, Cheng, Vincent Chi-Chung, Cai, Jian-Piao, Chu, Hin, Chan, Kwok-Hung, To, Kelvin Kai-Wang, Sridhar, Siddharth, Yuen, Kwok-Yung

“…Abstract Background Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is believed to be mostly…”
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Clofazimine broadly inhibits coronaviruses including SARS-CoV-2 by Yuan, Shuofeng, Yin, Xin, Meng, Xiangzhi, Chan, Jasper Fuk-Woo, Ye, Zi-Wei, Riva, Laura, Pache, Lars, Chan, Chris Chun-Yiu, Lai, Pok-Man, Chan, Chris Chung-Sing, Poon, Vincent Kwok-Man, Lee, Andrew Chak-Yiu, Matsunaga, Naoko, Pu, Yuan, Yuen, Chun-Kit, Cao, Jianli, Liang, Ronghui, Tang, Kaiming, Sheng, Li, Du, Yushen, Xu, Wan, Lau, Chit-Ying, Sit, Ko-Yung, Au, Wing-Kuk, Wang, Runming, Zhang, Yu-Yuan, Tang, Yan-Dong, Clausen, Thomas Mandel, Pihl, Jessica, Oh, Juntaek, Sze, Kong-Hung, Zhang, Anna Jinxia, Chu, Hin, Kok, Kin-Hang, Wang, Dong, Cai, Xue-Hui, Esko, Jeffrey D., Hung, Ivan Fan-Ngai, Li, Ronald Adolphus, Chen, Honglin, Sun, Hongzhe, Jin, Dong-Yan, Sun, Ren, Chanda, Sumit K., Yuen, Kwok-Yung

“…The COVID-19 pandemic is the third outbreak this century of a zoonotic disease caused by a coronavirus, following the emergence of severe acute respiratory…”
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Pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron in Syrian hamsters by Yuan, Shuofeng, Ye, Zi-Wei, Liang, Ronghui, Tang, Kaiming, Zhang, Anna Jinxia, Lu, Gang, Ong, Chon Phin, Man Poon, Vincent Kwok, Chan, Chris Chung-Sing, Mok, Bobo Wing-Yee, Qin, Zhenzhi, Xie, Yubin, Chu, Allen Wing-Ho, Chan, Wan-Mui, Ip, Jonathan Daniel, Sun, Haoran, Tsang, Jessica Oi-Ling, Yuen, Terrence Tsz-Tai, Chik, Kenn Ka-Heng, Chan, Chris Chun-Yiu, Cai, Jian-Piao, Luo, Cuiting, Lu, Lu, Yip, Cyril Chik-Yan, Chu, Hin, To, Kelvin Kai-Wang, Chen, Honglin, Jin, Dong-Yan, Yuen, Kwok-Yung, Chan, Jasper Fuk-Woo

“…The in vivo pathogenicity, transmissibility, and fitness of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron (B.1.1.529) variant are…”
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Severe Acute Respiratory Syndrome Coronavirus 2 Infects and Damages the Mature and Immature Olfactory Sensory Neurons of Hamsters by Zhang, Anna Jinxia, Lee, Andrew Chak-Yiu, Chu, Hin, Chan, Jasper Fuk-Woo, Fan, Zhimeng, Li, Can, Liu, Feifei, Chen, Yanxia, Yuan, Shuofeng, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Cai, Jian-Piao, Wu, Kenneth Lap-Kei, Sridhar, Siddharth, Chan, Ying-Shing, Yuen, Kwok-Yung

“…Abstract Background Coronavirus disease 2019 (COVID-19) is primarily an acute respiratory tract infection. Distinctively, a substantial proportion of COVID-19…”
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Coinfection by Severe Acute Respiratory Syndrome Coronavirus 2 and Influenza A(H1N1)pdm09 Virus Enhances the Severity of Pneumonia in Golden Syrian Hamsters by Zhang, Anna Jinxia, Lee, Andrew Chak-Yiu, Chan, Jasper Fuk-Woo, Liu, Feifei, Li, Can, Chen, Yanxia, Chu, Hin, Lau, Siu-Ying, Wang, Pui, Chan, Chris Chung-Sing, Poon, Vincent Kwok-Man, Yuan, Shuofeng, To, Kelvin Kai-Wang, Chen, Honglin, Yuen, Kwok-Yung

“…Abstract Background Clinical outcomes of the interaction between the co-circulating pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and…”
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Cross-linking peptide and repurposed drugs inhibit both entry pathways of SARS-CoV-2 by Zhao, Hanjun, To, Kelvin K. W., Lam, Hoiyan, Zhou, Xinxin, Chan, Jasper Fuk-Woo, Peng, Zheng, Lee, Andrew C. Y., Cai, Jianpiao, Chan, Wan-Mui, Ip, Jonathan Daniel, Chan, Chris Chung-Sing, Yeung, Man Lung, Zhang, Anna Jinxia, Chu, Allen Wing Ho, Jiang, Shibo, Yuen, Kwok-Yung

“…Up to date, effective antivirals have not been widely available for treating COVID-19. In this study, we identify a dual-functional cross-linking peptide 8P9R…”
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SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters by Qiao, Wei, Lau, Hui En, Xie, Huizhi, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Chu, Hin, Yuan, Shuofeng, Yuen, Terrence Tsz-Tai, Chik, Kenn Ka-Heng, Tsang, Jessica Oi-Ling, Chan, Chris Chun-Yiu, Cai, Jian-Piao, Luo, Cuiting, Yuen, Kwok-Yung, Cheung, Kenneth Man-Chee, Chan, Jasper Fuk-Woo, Yeung, Kelvin Wai-Kwok

“…Extrapulmonary complications of different organ systems have been increasingly recognized in patients with severe or chronic Coronavirus Disease 2019…”
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Novel antiviral activity and mechanism of bromocriptine as a Zika virus NS2B-NS3 protease inhibitor by Chan, Jasper Fuk-Woo, Chik, Kenn Ka-Heng, Yuan, Shuofeng, Yip, Cyril Chik-Yan, Zhu, Zheng, Tee, Kah-Meng, Tsang, Jessica Oi-Ling, Chan, Chris Chung-Sing, Poon, Vincent Kwok-Man, Lu, Gang, Zhang, Anna Jinxia, Lai, Kin-Kui, Chan, Kwok-Hung, Kao, Richard Yi-Tsun, Yuen, Kwok-Yung

“…Zika virus (ZIKV) infection is associated with congenital malformations in infected fetuses and severe neurological and other systemic complications in adults…”
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A broadly neutralizing antibody protects Syrian hamsters against SARS-CoV-2 Omicron challenge by Zhou, Biao, Zhou, Runhong, Tang, Bingjie, Chan, Jasper Fuk-Woo, Luo, Mengxiao, Peng, Qiaoli, Yuan, Shuofeng, Liu, Hang, Mok, Bobo Wing-Yee, Chen, Bohao, Wang, Pui, Poon, Vincent Kwok-Man, Chu, Hin, Chan, Chris Chung-Sing, Tsang, Jessica Oi-Ling, Chan, Chris Chun-Yiu, Au, Ka-Kit, Man, Hiu-On, Lu, Lu, To, Kelvin Kai-Wang, Chen, Honglin, Yuen, Kwok-Yung, Dang, Shangyu, Chen, Zhiwei

“…The strikingly high transmissibility and antibody evasion of SARS-CoV-2 Omicron variants have posed great challenges to the efficacy of current vaccines and…”
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Oral SARS-CoV-2 Inoculation Establishes Subclinical Respiratory Infection with Virus Shedding in Golden Syrian Hamsters by Lee, Andrew Chak-Yiu, Zhang, Anna Jinxia, Chan, Jasper Fuk-Woo, Li, Can, Fan, Zhimeng, Liu, Feifei, Chen, Yanxia, Liang, Ronghui, Sridhar, Siddharth, Cai, Jian-Piao, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, To, Kelvin Kai-Wang, Yuan, Shuofeng, Zhou, Jie, Chu, Hin, Yuen, Kwok-Yung

“…Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is transmitted largely by respiratory droplets or airborne aerosols. Despite being frequently…”
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Beneficial effect of combinational methylprednisolone and remdesivir in hamster model of SARS-CoV-2 infection by Ye, Zi-Wei, Yuan, Shuofeng, Chan, Jasper Fuk-Woo, Zhang, Anna Jinxia, Yu, Ching-Yun, Ong, Chon Phin, Yang, Dong, Chan, Chris Chun-Yiu, Tang, Kaiming, Cao, Jianli, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Cai, Jian-Piao, Chu, Hin, Yuen, Kwok-Yung, Jin, Dong-Yan

“…Effective treatments for coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are urgently needed…”
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The spike receptor-binding motif G496S substitution determines the replication fitness of SARS-CoV-2 Omicron sublineage by Liang, Ronghui, Ye, Zi-Wei, Ong, Chon Phin, Qin, Zhenzhi, Xie, Yubin, Fan, Yilan, Tang, Kaiming, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Yang, Xiaomeng, Cao, Hehe, Wang, Kun, Sun, Haoran, Hu, Bodan, Cai, Jian-Piao, Luo, Cuiting, Chik, Kenn Ka-Heng, Chu, Hin, Zheng, Yi, Yuen, Kwok-Yung, Chan, Jasper Fuk-Woo, Jin, Dong-Yan, Yuan, Shuofeng

“…The replication and pathogenicity of SARS-CoV-2 Omicron BA.2 are comparable to that of BA.1 in experimental animal models. However, BA.2 has rapidly emerged to…”
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A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivo by Chan, Jasper Fuk-Woo, Oh, Yoo Jin, Yuan, Shuofeng, Chu, Hin, Yeung, Man-Lung, Canena, Daniel, Chan, Chris Chung-Sing, Poon, Vincent Kwok-Man, Chan, Chris Chun-Yiu, Zhang, Anna Jinxia, Cai, Jian-Piao, Ye, Zi-Wei, Wen, Lei, Yuen, Terrence Tsz-Tai, Chik, Kenn Ka-Heng, Shuai, Huiping, Wang, Yixin, Hou, Yuxin, Luo, Cuiting, Chan, Wan-Mui, Qin, Zhenzhi, Sit, Ko-Yung, Au, Wing-Kuk, Legendre, Maureen, Zhu, Rong, Hain, Lisa, Seferovic, Hannah, Tampé, Robert, To, Kelvin Kai-Wang, Chan, Kwok-Hung, Thomas, Dafydd Gareth, Klausberger, Miriam, Xu, Cheng, Moon, James J, Stadlmann, Johannes, Penninger, Josef M, Oostenbrink, Chris, Hinterdorfer, Peter, Yuen, Kwok-Yung, Markovitz, David M

“…"Pan-coronavirus" antivirals targeting conserved viral components can be designed. Here, we show that the rationally engineered H84T-banana lectin…”
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P21-activated kinase 1 (PAK1)-mediated cytoskeleton rearrangement promotes SARS-CoV-2 entry and ACE2 autophagic degradation by Liu, Ming, Lu, Bingtai, Li, Yue, Yuan, Shuofeng, Zhuang, Zhen, Li, Guangyu, Wang, Dong, Ma, Liuheyi, Zhu, Jianheng, Zhao, Jinglu, Chan, Chris Chung-Sing, Poon, Vincent Kwok-Man, Chik, Kenn Ka-Heng, Zhao, Zhiyao, Xian, Huifang, Zhao, Jingxian, Zhao, Jincun, Chan, Jasper Fuk-Woo, Zhang, Yuxia

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has had a significant impact on…”
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A novel linker-immunodominant site (LIS) vaccine targeting the SARS-CoV-2 spike protein protects against severe COVID-19 in Syrian hamsters by Zhang, Bao-Zhong, Wang, Xiaolei, Yuan, Shuofeng, Li, Wenjun, Dou, Ying, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Cai, Jian-Piao, Chik, Kenn KaHeng, Tang, Kaiming, Chan, Chris Chun-Yiu, Hu, Ye-Fan, Hu, Jing-Chu, Badea, Smaranda Ruxandra, Gong, Hua-Rui, Lin, Xuansheng, Chu, Hin, Li, Xuechen, To, Kelvin Kai-Wang, Liu, Li, Chen, Zhiwei, Hung, Ivan Fan-Ngai, Yuen, Kwok Yung, Chan, Jasper Fuk-Woo, Huang, Jian-Dong

“…The Coronavirus Disease 2019 (COVID-19) pandemic is unlikely to abate until sufficient herd immunity is built up by either natural infection or vaccination. We…”
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Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs by Chan, Jasper Fuk-Woo, Yip, Cyril Chik-Yan, Tsang, Jessica Oi-Ling, Tee, Kah-Meng, Cai, Jian-Piao, Chik, Kenn Ka-Heng, Zhu, Zheng, Chan, Chris Chung-Sing, Choi, Garnet Kwan-Yue, Sridhar, Siddharth, Zhang, Anna Jinxia, Lu, Gang, Chiu, Kin, Lo, Amy Cheuk-Yin, Tsao, Sai-Wah, Kok, Kin-Hang, Jin, Dong-Yan, Chan, Kwok-Hung, Yuen, Kwok-Yung

“…Zika virus (ZIKV) is unique among human-pathogenic flaviviruses by its association with congenital anomalies and trans-placental and sexual human-to-human…”
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An H5N1-based matrix protein 2 ectodomain tetrameric peptide vaccine provides cross-protection against lethal infection with H7N9 influenza virus by Leung, Ho-Chuen, Chan, Chris Chung-Sing, Poon, Vincent Kwok-Man, Zhao, Han-Jun, Cheung, Chung-Yan, Ng, Fai, Huang, Jian-Dong, Zheng, Bo-Jian

“…In March 2013, a patient infected with a novel avian influenza A H7N9 virus was reported in China. Since then, there have been 458 confirmed infection cases…”
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SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target by Yuan, Shuofeng, Chu, Hin, Chan, Jasper Fuk-Woo, Ye, Zi-Wei, Wen, Lei, Yan, Bingpeng, Lai, Pok-Man, Tee, Kah-Meng, Huang, Jingjing, Chen, Dongdong, Li, Cun, Zhao, Xiaoyu, Yang, Dong, Chiu, Man Chun, Yip, Cyril, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Sze, Kong-Hung, Zhou, Jie, Chan, Ivy Hau-Yee, Kok, Kin-Hang, To, Kelvin Kai-Wang, Kao, Richard Yi-Tsun, Lau, Johnson Yiu-Nam, Jin, Dong-Yan, Perlman, Stanley, Yuen, Kwok-Yung

“…Viruses are obligate intracellular microbes that exploit the host metabolic machineries to meet their biosynthetic demands, making these host pathways…”
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