Search Results - "Chan, Chris"

Clofazimine broadly inhibits coronaviruses including SARS-CoV-2 by Yuan, Shuofeng, Yin, Xin, Meng, Xiangzhi, Chan, Jasper Fuk-Woo, Ye, Zi-Wei, Riva, Laura, Pache, Lars, Chan, Chris Chun-Yiu, Lai, Pok-Man, Chan, Chris Chung-Sing, Poon, Vincent Kwok-Man, Lee, Andrew Chak-Yiu, Matsunaga, Naoko, Pu, Yuan, Yuen, Chun-Kit, Cao, Jianli, Liang, Ronghui, Tang, Kaiming, Sheng, Li, Du, Yushen, Xu, Wan, Lau, Chit-Ying, Sit, Ko-Yung, Au, Wing-Kuk, Wang, Runming, Zhang, Yu-Yuan, Tang, Yan-Dong, Clausen, Thomas Mandel, Pihl, Jessica, Oh, Juntaek, Sze, Kong-Hung, Zhang, Anna Jinxia, Chu, Hin, Kok, Kin-Hang, Wang, Dong, Cai, Xue-Hui, Esko, Jeffrey D., Hung, Ivan Fan-Ngai, Li, Ronald Adolphus, Chen, Honglin, Sun, Hongzhe, Jin, Dong-Yan, Sun, Ren, Chanda, Sumit K., Yuen, Kwok-Yung

“…The COVID-19 pandemic is the third outbreak this century of a zoonotic disease caused by a coronavirus, following the emergence of severe acute respiratory…”
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Pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron in Syrian hamsters by Yuan, Shuofeng, Ye, Zi-Wei, Liang, Ronghui, Tang, Kaiming, Zhang, Anna Jinxia, Lu, Gang, Ong, Chon Phin, Man Poon, Vincent Kwok, Chan, Chris Chung-Sing, Mok, Bobo Wing-Yee, Qin, Zhenzhi, Xie, Yubin, Chu, Allen Wing-Ho, Chan, Wan-Mui, Ip, Jonathan Daniel, Sun, Haoran, Tsang, Jessica Oi-Ling, Yuen, Terrence Tsz-Tai, Chik, Kenn Ka-Heng, Chan, Chris Chun-Yiu, Cai, Jian-Piao, Luo, Cuiting, Lu, Lu, Yip, Cyril Chik-Yan, Chu, Hin, To, Kelvin Kai-Wang, Chen, Honglin, Jin, Dong-Yan, Yuen, Kwok-Yung, Chan, Jasper Fuk-Woo

“…The in vivo pathogenicity, transmissibility, and fitness of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron (B.1.1.529) variant are…”
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SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters by Qiao, Wei, Lau, Hui En, Xie, Huizhi, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Chu, Hin, Yuan, Shuofeng, Yuen, Terrence Tsz-Tai, Chik, Kenn Ka-Heng, Tsang, Jessica Oi-Ling, Chan, Chris Chun-Yiu, Cai, Jian-Piao, Luo, Cuiting, Yuen, Kwok-Yung, Cheung, Kenneth Man-Chee, Chan, Jasper Fuk-Woo, Yeung, Kelvin Wai-Kwok

“…Extrapulmonary complications of different organ systems have been increasingly recognized in patients with severe or chronic Coronavirus Disease 2019…”
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Robust SARS-CoV-2 infection in nasal turbinates after treatment with systemic neutralizing antibodies by Zhou, Dongyan, Chan, Jasper Fuk-Woo, Zhou, Biao, Zhou, Runhong, Li, Shuang, Shan, Sisi, Liu, Li, Zhang, Anna Jinxia, Chen, Serena J., Chan, Chris Chung-Sing, Xu, Haoran, Poon, Vincent Kwok-Man, Yuan, Shuofeng, Li, Cun, Chik, Kenn Ka-Heng, Chan, Chris Chun-Yiu, Cao, Jianli, Chan, Chun-Yin, Kwan, Ka-Yi, Du, Zhenglong, Lau, Thomas Tsz-Kan, Zhang, Qi, Zhou, Jie, To, Kelvin Kai-Wang, Zhang, Linqi, Ho, David D., Yuen, Kwok-Yung, Chen, Zhiwei

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized by a burst in the upper respiratory portal for high transmissibility. To…”
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Real-time Monitoring Excitation Dynamics of Human Telomeric Guanine Quadruplexes: Effect of Folding Topology, Metal Cation, and Confinement by Nanocavity Water Pool by Ma, Chensheng, Chan, Ruth C.-T, Chan, Chris T.-L, Wong, Allen K.-W, Kwok, Wai-Ming

“…Guanine­(G)-rich human telomeric (HT) DNA repeats, crucial to maintenance of genome stability, readily form G-quadruplexes (GQs) with various folding…”
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A broadly neutralizing antibody protects Syrian hamsters against SARS-CoV-2 Omicron challenge by Zhou, Biao, Zhou, Runhong, Tang, Bingjie, Chan, Jasper Fuk-Woo, Luo, Mengxiao, Peng, Qiaoli, Yuan, Shuofeng, Liu, Hang, Mok, Bobo Wing-Yee, Chen, Bohao, Wang, Pui, Poon, Vincent Kwok-Man, Chu, Hin, Chan, Chris Chung-Sing, Tsang, Jessica Oi-Ling, Chan, Chris Chun-Yiu, Au, Ka-Kit, Man, Hiu-On, Lu, Lu, To, Kelvin Kai-Wang, Chen, Honglin, Yuen, Kwok-Yung, Dang, Shangyu, Chen, Zhiwei

“…The strikingly high transmissibility and antibody evasion of SARS-CoV-2 Omicron variants have posed great challenges to the efficacy of current vaccines and…”
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Simulation of the Clinical and Pathological Manifestations of Coronavirus Disease 2019 (COVID-19) in a Golden Syrian Hamster Model: Implications for Disease Pathogenesis and Transmissibility by Chan, Jasper Fuk-Woo, Zhang, Anna Jinxia, Yuan, Shuofeng, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Lee, Andrew Chak-Yiu, Chan, Wan-Mui, Fan, Zhimeng, Tsoi, Hoi-Wah, Wen, Lei, Liang, Ronghui, Cao, Jianli, Chen, Yanxia, Tang, Kaiming, Luo, Cuiting, Cai, Jian-Piao, Kok, Kin-Hang, Chu, Hin, Chan, Kwok-Hung, Sridhar, Siddharth, Chen, Zhiwei, Chen, Honglin, To, Kelvin Kai-Wang, Yuen, Kwok-Yung

“…Abstract Background A physiological small-animal model that resembles COVID-19 with low mortality is lacking. Methods Molecular docking on the binding between…”
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Discrete responses of erythrocytes, platelets, and von Willebrand factor to shear by Chan, Chris H.H., Simmonds, Michael J., Fraser, Katharine H., Igarashi, Kosuke, Ki, Katrina K., Murashige, Tomotaka, Joseph, Mary T., Fraser, John F., Tansley, Geoff D., Watanabe, Nobuo

“…Despite decades of technological advancements in blood-contacting medical devices, complications related to shear flow-induced blood trauma are still…”
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Low Environmental Temperature Exacerbates Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Golden Syrian Hamsters by Chan, Jasper Fuk Woo, Poon, Vincent Kwok Man, Chan, Chris Chung Sing, Chik, Kenn Ka Heng, Tsang, Jessica Oi Ling, Zou, Zijiao, Chan, Chris Chun Yiu, Lee, Andrew Chak Yiu, Li, Can, Liang, Ronghui, Cao, Jianli, Tang, Kaiming, Yuen, Terrence Tsz Tai, Hu, Bingjie, Huang, Xiner, Chai, Yue, Shuai, Huiping, Luo, Cuiting, Cai, Jian Piao, Chan, Kwok Hung, Sridhar, Siddharth, Yin, Feifei, Kok, Kin Hang, Chu, Hin, Zhang, Anna Jinxia, Yuan, Shuofeng, Yuen, Kwok Yung

“…Abstract Background The effect of low environmental temperature on viral shedding and disease severity of Coronavirus Disease 2019 (COVID-19) is uncertain…”
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Surgical Mask Partition Reduces the Risk of Noncontact Transmission in a Golden Syrian Hamster Model for Coronavirus Disease 2019 (COVID-19) by Chan, Jasper Fuk-Woo, Yuan, Shuofeng, Zhang, Anna Jinxia, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Lee, Andrew Chak-Yiu, Fan, Zhimeng, Li, Can, Liang, Ronghui, Cao, Jianli, Tang, Kaiming, Luo, Cuiting, Cheng, Vincent Chi-Chung, Cai, Jian-Piao, Chu, Hin, Chan, Kwok-Hung, To, Kelvin Kai-Wang, Sridhar, Siddharth, Yuen, Kwok-Yung

“…Abstract Background Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is believed to be mostly…”
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Anti-Fouling Surfaces for Extracorporeal Membrane Oxygenation by Surface Grafting of Hydrophilic Sulfoxide Polymers by Zhang, Yuhao, Zhang, Meili, Xu, Xin, Chan, Chris H. H., Peng, Hui, Hill, David J. T., Fu, Changkui, Fraser, John, Whittaker, Andrew K.

“…Non-thrombogenic surfaces for extracorporeal membrane oxygenation (ECMO) devices are important to increase their duration of usage and to enable long-term life…”
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Wild type and mutant 2009 pandemic influenza A (H1N1) viruses cause more severe disease and higher mortality in pregnant BALB/c mice by Chan, Kwok-Hung, Zhang, Anna J X, To, Kelvin K W, Chan, Chris C S, Poon, Vincent K M, Guo, Kunyuan, Ng, Fai, Zhang, Qi-Wei, Leung, Virtual H C, Cheung, Annie N Y, Lau, Candy C Y, Woo, Patrick C Y, Tse, Herman, Wu, Wailan, Chen, Honglin, Zheng, Bo-Jian, Yuen, Kwok-Yung

“…Pregnant women infected by the pandemic influenza A (H1N1) 2009 virus had more severe disease and higher mortality but its pathogenesis is still unclear. We…”
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Severe Acute Respiratory Syndrome Coronavirus 2 Infects and Damages the Mature and Immature Olfactory Sensory Neurons of Hamsters by Zhang, Anna Jinxia, Lee, Andrew Chak-Yiu, Chu, Hin, Chan, Jasper Fuk-Woo, Fan, Zhimeng, Li, Can, Liu, Feifei, Chen, Yanxia, Yuan, Shuofeng, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Cai, Jian-Piao, Wu, Kenneth Lap-Kei, Sridhar, Siddharth, Chan, Ying-Shing, Yuen, Kwok-Yung

“…Abstract Background Coronavirus disease 2019 (COVID-19) is primarily an acute respiratory tract infection. Distinctively, a substantial proportion of COVID-19…”
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Beneficial effect of combinational methylprednisolone and remdesivir in hamster model of SARS-CoV-2 infection by Ye, Zi-Wei, Yuan, Shuofeng, Chan, Jasper Fuk-Woo, Zhang, Anna Jinxia, Yu, Ching-Yun, Ong, Chon Phin, Yang, Dong, Chan, Chris Chun-Yiu, Tang, Kaiming, Cao, Jianli, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Cai, Jian-Piao, Chu, Hin, Yuen, Kwok-Yung, Jin, Dong-Yan

“…Effective treatments for coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are urgently needed…”
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Recombinant receptor-binding domain of SARS-CoV spike protein expressed in mammalian, insect and E. coli cells elicits potent neutralizing antibody and protective immunity by Du, Lanying, Zhao, Guangyu, Chan, Chris C.S, Sun, Shihui, Chen, Min, Liu, Zhonghua, Guo, Hongxiang, He, Yuxian, Zhou, Yusen, Zheng, Bo-Jian, Jiang, Shibo

“…Abstract Severe acute respiratory syndrome (SARS) is a newly emerging infectious disease. The potential recurrence of the disease from animal reservoirs…”
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Coinfection by Severe Acute Respiratory Syndrome Coronavirus 2 and Influenza A(H1N1)pdm09 Virus Enhances the Severity of Pneumonia in Golden Syrian Hamsters by Zhang, Anna Jinxia, Lee, Andrew Chak-Yiu, Chan, Jasper Fuk-Woo, Liu, Feifei, Li, Can, Chen, Yanxia, Chu, Hin, Lau, Siu-Ying, Wang, Pui, Chan, Chris Chung-Sing, Poon, Vincent Kwok-Man, Yuan, Shuofeng, To, Kelvin Kai-Wang, Chen, Honglin, Yuen, Kwok-Yung

“…Abstract Background Clinical outcomes of the interaction between the co-circulating pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and…”
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Anti-thrombogenic Surface Coatings for Extracorporeal Membrane Oxygenation: A Narrative Review by Zhang, Meili, Pauls, Jo P, Bartnikowski, Nicole, Haymet, Andrew B, Chan, Chris H. H, Suen, Jacky Y, Schneider, Bailey, Ki, Katrina K, Whittaker, Andrew K, Dargusch, Matthew S, Fraser, John F

“…Extracorporeal membrane oxygenation (ECMO) is used in critical care to manage patients with severe respiratory and cardiac failure. ECMO brings blood from a…”
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Economic restructuring and migrant workers' coping strategies in China's Pearl River Delta by Wang, Xu, Chan, Chris King-Chi, Yang, Linchuan

“…To tackle internal and external challenges, the Chinese government has made great efforts to promote economic upgrading, but little scholarly attention has…”
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Constrained Labour Agency and the Changing Regulatory Regime in China by Chan, Chris King-Chi

“…ABSTRACT Using the concept of ‘constrained agency’ introduced by Neil Coe and David Jordhus‐Lier, this article attempts to evaluate the possibilities and…”
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A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivo by Chan, Jasper Fuk-Woo, Oh, Yoo Jin, Yuan, Shuofeng, Chu, Hin, Yeung, Man-Lung, Canena, Daniel, Chan, Chris Chung-Sing, Poon, Vincent Kwok-Man, Chan, Chris Chun-Yiu, Zhang, Anna Jinxia, Cai, Jian-Piao, Ye, Zi-Wei, Wen, Lei, Yuen, Terrence Tsz-Tai, Chik, Kenn Ka-Heng, Shuai, Huiping, Wang, Yixin, Hou, Yuxin, Luo, Cuiting, Chan, Wan-Mui, Qin, Zhenzhi, Sit, Ko-Yung, Au, Wing-Kuk, Legendre, Maureen, Zhu, Rong, Hain, Lisa, Seferovic, Hannah, Tampé, Robert, To, Kelvin Kai-Wang, Chan, Kwok-Hung, Thomas, Dafydd Gareth, Klausberger, Miriam, Xu, Cheng, Moon, James J, Stadlmann, Johannes, Penninger, Josef M, Oostenbrink, Chris, Hinterdorfer, Peter, Yuen, Kwok-Yung, Markovitz, David M

“…"Pan-coronavirus" antivirals targeting conserved viral components can be designed. Here, we show that the rationally engineered H84T-banana lectin…”
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