Search Results - "Chan, Chi Chung"

Oral arsenic trioxide incorporation into frontline treatment with all‐trans retinoic acid and chemotherapy in newly diagnosed acute promyelocytic leukemia: A 5‐year prospective study by Gill, Harinder, Kumana, Cyrus R., Yim, Rita, Hwang, Yu‐Yan, Chan, Thomas S. Y., Yip, Sze‐Fai, Lee, Harold K. K., Mak, Vivien, Lau, June S. M., Chan, Chi‐Chung, Kho, Bonnie, Wong, Raymond S. M., Li, Wa, Lin, Shek‐Yin, Lau, Chi‐Kuen, Ip, Ho‐Wan, Leung, Rock Y. Y., Lam, Clarence C. K., Kwong, Yok‐Lam

“…Background Strategies using oral arsenic trioxide (As2O3) are efficacious in relapsed acute promyelocytic leukemia (APL), but they have not been examined in…”
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The Relationship between Training Load and Injury Risk in Basketball: A Systematic Review by Chan, Chi-Chung, Yung, Patrick Shu-Hang, Mok, Kam-Ming

“…The relationship between training load and injury risk in basketball is an important area in sports injury prevention and performance enhancement; however,…”
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The C3a Anaphylatoxin Receptor Is a Key Mediator of Insulin Resistance and Functions by Modulating Adipose Tissue Macrophage Infiltration and Activation by Mamane, Yaël, Chung Chan, Chi, Lavallee, Genevieve, Morin, Nicolas, Xu, Li-Jing, Huang, JingQi, Gordon, Robert, Thomas, Winston, Lamb, John, Schadt, Eric E, Kennedy, Brian P, Mancini, Joseph A

“…The C3a Anaphylatoxin Receptor Is a Key Mediator of Insulin Resistance and Functions by Modulating Adipose Tissue Macrophage Infiltration and Activation Yaël…”
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Activating JAK1 mutation may predict the sensitivity of JAK-STAT inhibition in hepatocellular carcinoma by Yang, Shuqun, Luo, Chonglin, Gu, Qingyang, Xu, Qiang, Wang, Guan, Sun, Hongye, Qian, Ziliang, Tan, Yexiong, Qin, Yuxin, Shen, Yuhong, Xu, Xiaowei, Chen, Shu-Hui, Chan, Chi-Chung, Wang, Hongyang, Mao, Mao, Fang, Douglas D

“…Hepatocellular carcinoma (HCC) is the fifth most common type of cancers worldwide. However, current therapeutic approaches for this epidemic disease are…”
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Deletion of phosphodiesterase 4D in mice shortens α2-adrenoceptor–mediated anesthesia, a behavioral correlate of emesis by Robichaud, Annette, Stamatiou, Panagiota B., Jin, S.-L.Catherine, Lachance, Nicholas, MacDonald, Dwight, Laliberté, France, Liu, Susana, Huang, Zheng, Conti, Marco, Chan, Chi-Chung

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Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene by Elchebly, M, Payette, P, Michaliszyn, E, Cromlish, W, Collins, S, Loy, A.L, Normandin, D, Cheng, A, Himms-Hagen, J, Chan, C.C

“…Protein tyrosine phosphatase-1B (PTP-1B) has been implicated in the negative regulation of insulin signaling. Disruption of the mouse homolog of the gene…”
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Clofarabine, cytarabine, and mitoxantrone in refractory/relapsed acute myeloid leukemia: High response rates and effective bridge to allogeneic hematopoietic stem cell transplantation by Gill, Harinder, Yim, Rita, Pang, Herbert H., Lee, Paul, Chan, Thomas S. Y., Hwang, Yu‐Yan, Leung, Garret M. K., Ip, Ho‐Wan, Leung, Rock Y. Y., Yip, Sze‐Fai, Kho, Bonnie, Lee, Harold K. K., Mak, Vivien, Chan, Chi‐Chung, Lau, June S. M., Lau, Chi‐Kuen, Lin, Shek‐Yin, Wong, Raymond S. M., Li, Wa, Ma, Edmond S. K., Li, Jun, Panagiotou, Gianni, Sim, Joycelyn P. Y., Lie, Albert K. W., Kwong, Yok‐Lam

“…Clofarabine is active in refractory/relapsed acute myeloid leukemia (AML). In this phase 2 study, we treated 18‐ to 65‐year‐old AML patients refractory to…”
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Cloning, Expression, and Up-regulation of Inducible Rat Prostaglandin E Synthase during Lipopolysaccharide-induced Pyresis and Adjuvant-induced Arthritis by Mancini, Joseph A., Blood, Katherine, Guay, Jocelyne, Gordon, Robert, Claveau, David, Chan, Chi-Chung, Riendeau, Denis

“…We have cloned and expressed the inducible form of prostaglandin (PG) E synthase from rat and characterized its regulation of expression in several tissues…”
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Plasma-based approach to measure target engagement for liver-targeting stearoyl-CoA desaturase 1 inhibitors by Landry, France, Chan, Chi-Chung, Huang, Zheng, Leclair, Gregoire, Li, Chun Sing, Oballa, Renata, Zhang, Lei, Bateman, Kevin

“…A positive correlation between stearoyl-CoA desaturase (SCD)1 expression and metabolic diseases has been reported in rodents and humans. These findings…”
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Neurologic and cognitive outcomes associated with the clinical use of xenon: a systematic review and meta-analysis of randomized-controlled trials by Law, Lawrence Siu-Chun, Lo, Elaine Ah-Gi, Chan, Caspar Chi-Chung, Gan, Tong Joo

“…Background Xenon has been shown to have positive neurologic effects in various pre-clinical models. This study systematically reviewed the…”
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Discovery and preclinical evaluations of TQB3616, a novel CDK4-biased inhibitor by Xu, Zhaobing, Liu, Yingchun, Song, Baohui, Ren, Bingjie, Xu, Xiongbin, Lin, Ruibin, Zhu, Xiaoyu, Chen, Chen, Yang, Shuqun, Zhu, Yusong, Jiang, Wen, Li, Wei, Xia, Yuanfeng, Hu, Lihong, Chen, Shuhui, Chan, Chi-chung, Li, Jian, Zhang, Xiquan, Yang, Ling, Tian, Xin, Ding, Charles Z.

“…[Display omitted] Among small-molecule CDK4/6 inhibitors (palbociclib, ribociclib, and abemaciclib) approved for metastatic breast cancers, abemaciclib has a…”
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Discovery and preclinical profile of LX-039, a novel indole-based oral selective estrogen receptor degrader (SERD) by Lu, Jianyu, Chan, Chi-chung, Sun, Deheng, Hu, Guoping, He, Huijun, Li, Jian, Dong, Jiaqiang, Liu, Kai, Shen, Liang, Hu, Lihong, Gu, Qingyang, Chen, Shuhui, Wang, Tielin, Gong, Ting, Tang, Wei, Li, Xiaoting, Zhu, Xiaotong, Zeng, Xu, Zhu, Yingjie, Xia, Yuanfeng, Huang, Yuanyuan, Zhu, Yusong, Liu, Zhenteng, Ding, Charles Z.

“…[Display omitted] We previously described the discovery of a novel indole series compounds as oral SERD for ER positive breast cancer treatment. Further SAR…”
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Design, syntheses and evaluations of novel indole derivatives as orally selective estrogen receptor degraders (SERD) by Dong, Jiaqiang, Wang, Tie-lin, Lu, Jianyu, Ding, Charles Z., Hu, Lihong, Hu, Guoping, He, Huijun, Zeng, Xu, Li, Xiaoting, Sun, Deheng, Zhu, Yingjie, Shen, Liang, Gu, Qingyang, Chan, Chi-chung, Xia, Yuanfeng, Li, Jian, Chen, Shuhui

“…[Display omitted] Most estrogen receptor positive (ER +) breast cancers depend on ER signaling pathway to develop. Clinical application of SERD fulvestrant…”
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Substituted coumarins as potent 5-lipoxygenase inhibitors by Grimm, Erich L., Brideau, Christine, Chauret, Nathalie, Chan, Chi-Chung, Delorme, Daniel, Ducharme, Yves, Ethier, Diane, Falgueyret, Jean-Pierre, Friesen, Richard W., Guay, Jocelyne, Hamel, Pierre, Riendeau, Denis, Soucy-Breau, Chantal, Tagari, Philip, Girard, Yves

“…A novel series of substituted coumarin derivatives has been synthesized. SAR studies in this series led to the identification of inhibitor 1. Leukotriene…”
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HIP1-ALK, a novel ALK fusion variant that responds to crizotinib by Fang, Douglas D, Zhang, Bin, Gu, Qingyang, Lira, Maruja, Xu, Qiang, Sun, Hongye, Qian, Maoxiang, Sheng, Weiqi, Ozeck, Mark, Wang, Zhenxiong, Zhang, Cathy, Chen, Xinsheng, Chen, Kevin X, Li, Jian, Chen, Shu-Hui, Christensen, James, Mao, Mao, Chan, Chi-Chung

“…The aim of this study was to identify anaplastic lymphoma kinase (ALK) rearrangements in lung cancer patient-derived xenograft (PDX) models and to explore…”
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Genomic characterization of a large panel of patient-derived hepatocellular carcinoma xenograft tumor models for preclinical development by Gu, Qingyang, Zhang, Bin, Sun, Hongye, Xu, Qiang, Tan, Yexiong, Wang, Guan, Luo, Qin, Xu, Weiguo, Yang, Shuqun, Li, Jian, Fu, Jing, Chen, Lei, Yuan, Shengxian, Liang, Guibai, Ji, Qunsheng, Chen, Shu-Hui, Chan, Chi-Chung, Zhou, Weiping, Xu, Xiaowei, Wang, Hongyang, Fang, Douglas D

“…Lack of clinically relevant tumor models dramatically hampers development of effective therapies for hepatocellular carcinoma (HCC). Establishment of…”
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5-Oxo-6,8,11,14-eicosatetraenoic Acid Stimulates the Release of the Eosinophil Survival Factor Granulocyte/Macrophage Colony-stimulating Factor from Monocytes by Stamatiou, Panagiota B, Chan, Chi-Chung, Monneret, Guillaume, Ethier, Diane, Rokach, Joshua, Powell, William S

“…Allergic diseases such as asthma are characterized by tissue eosinophilia induced by the combined effects of chemoattractants and cytokines. Lipid mediators…”
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Exploring the Potential of RET Kinase Inhibition for Irritable Bowel Syndrome: A Preclinical Investigation in Rodent Models of Colonic Hypersensitivity by Russell, John P, Mohammadi, Ehsan, Ligon, Casey O, Johnson, Anthony C, Gershon, Michael D, Rao, Meenakshi, Shen, Yuhong, Chan, Chi-Chung, Eidam, Hilary S, DeMartino, Michael P, Cheung, Mui, Oliff, Allen I, Kumar, Sanjay, Greenwood-Van Meerveld, Beverley

“…Abdominal pain represents a significant complaint in patients with irritable bowel syndrome (IBS). While the etiology of IBS is incompletely understood, prior…”
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Development of a Liver-Targeted Stearoyl-CoA Desaturase (SCD) Inhibitor (MK-8245) to Establish a Therapeutic Window for the Treatment of Diabetes and Dyslipidemia by Oballa, Renata M, Belair, Liette, Black, W. Cameron, Bleasby, Kelly, Chan, Chi Chung, Desroches, Carole, Du, Xiaobing, Gordon, Robert, Guay, Jocelyne, Guiral, Sebastien, Hafey, Michael J, Hamelin, Emelie, Huang, Zheng, Kennedy, Brian, Lachance, Nicolas, Landry, France, Li, Chun Sing, Mancini, Joseph, Normandin, Denis, Pocai, Alessandro, Powell, David A, Ramtohul, Yeeman K, Skorey, Kathryn, Sørensen, Dan, Sturkenboom, Wayne, Styhler, Angela, Waddleton, Deena M, Wang, Hao, Wong, Simon, Xu, Lijing, Zhang, Lei

“…The potential use of SCD inhibitors for the chronic treatment of diabetes and dyslipidemia has been limited by preclinical adverse events associated with…”
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Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes : Potential importance of selectivity over dipeptidyl peptidases 8 and 9 by LANKAS, George R, LEITING, Barbara, IPPOLITO, Dawn E, KIM, Dooseop, LYONS, Kathryn A, OK, Hyun O, PATEL, Reshma A, PETROV, Aleksandr N, PRYOR, Kelly Ann, XIAOXIA QIAN, REIGLE, Leah, WOODS, Andrea, ROY, Ranabir Sinha, WU, Joseph K, ZALLER, Dennis, XIAOPING ZHANG, LAN ZHU, WEBER, Ann E, THORNBERRY, Nancy A, EIERMANN, George J, BECONI, Maria G, BIFTU, Tesfaye, CHAN, Chi-Chung, EDMONDSON, Scott, FEENEY, William P, HUAIBING HE

“…Dipeptidyl peptidase (DPP)-IV inhibitors are a new approach to the treatment of type 2 diabetes. DPP-IV is a member of a family of serine peptidases that…”
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