Search Results - "Chan, Allen K."

Size-tagged preferred ends in maternal plasma DNA shed light on the production mechanism and show utility in noninvasive prenatal testing by Sun, Kun, Jiang, Peiyong, Wong, Ada I. C., Cheng, Yvonne K. Y., Cheng, Suk Hang, Zhang, Haiqiang, Chan, K. C. Allen, Leung, Tak Y., Chiu, Rossa W. K., Lo, Y. M. Dennis

“…Cell-free DNA in human plasma is nonrandomly fragmented and reflects genomewide nucleosomal organization. Previous studies had demonstrated tissue-specific…”
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Orientation-aware plasma cell-free DNA fragmentation analysis in open chromatin regions informs tissue of origin by Sun, Kun, Jiang, Peiyong, Cheng, Suk Hang, Cheng, Timothy H T, Wong, John, Wong, Vincent W S, Ng, Simon S M, Ma, Brigette B Y, Leung, Tak Y, Chan, Stephen L, Mok, Tony S K, Lai, Paul B S, Chan, Henry L Y, Sun, Hao, Chan, K C Allen, Chiu, Rossa W K, Lo, Y M Dennis

“…Cell-free DNA (cfDNA) in human plasma is a class of biomarkers with many current and potential future diagnostic applications. Recent studies have shown that…”
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Microfluidics Digital PCR Reveals a Higher than Expected Fraction of Fetal DNA in Maternal Plasma by Lun, Fiona M. F, Chiu, Rossa W. K, Allen Chan, K. C, Yeung Leung, Tak, Kin Lau, Tze, Dennis Lo, Y. M

“…The precise measurement of cell-free fetal DNA in maternal plasma facilitates noninvasive prenatal diagnosis of fetal chromosomal aneuploidies and other…”
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Sequencing-based counting and size profiling of plasma Epstein–Barr virus DNA enhance population screening of nasopharyngeal carcinoma by Lam, W. K. Jacky, Jiang, Peiyong, Chan, K. C. Allen, Cheng, Suk H., Zhang, Haiqiang, Peng, Wenlei, Tse, O. Y. Olivia, Tong, Yu K., Gai, Wanxia, Zee, Benny C. Y., Ma, Brigette B. Y., Hui, Edwin P., Chan, Anthony T. C., Woo, John K. S., Chiu, Rossa W. K., Lo, Y. M. Dennis

“…Circulating tumor-derived DNA testing for cancer screening has recently been demonstrated in a prospective study on identification of nasopharyngeal carcinoma…”
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Digital PCR Analysis of Maternal Plasma for Noninvasive Detection of Sickle Cell Anemia by BARRETT, Angela N, MCDONNELL, Thomas C. R, ALLEN CHAN, K. C, CHITTY, Lyn S

“…Cell-free fetal DNA (cffDNA) constitutes approximately 10% of the cell-free DNA in maternal plasma and is a suitable source of fetal genetic material for…”
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Noninvasive Prenatal Diagnosis of Congenital Adrenal Hyperplasia Using Cell-Free Fetal DNA in Maternal Plasma by New, Maria I, Tong, Yu K, Yuen, Tony, Jiang, Peiyong, Pina, Christian, Chan, K. C. Allen, Khattab, Ahmed, Liao, Gary J. W, Yau, Mabel, Kim, Se-Min, Chiu, Rossa W. K, Sun, Li, Zaidi, Mone, Lo, Y. M

“…Context: Congenital adrenal hyperplasia (CAH) is an autosomal recessive condition that arises from mutations in CYP21A2 gene, which encodes for the…”
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Methy-Pipe: an integrated bioinformatics pipeline for whole genome bisulfite sequencing data analysis by Jiang, Peiyong, Sun, Kun, Lun, Fiona M F, Guo, Andy M, Wang, Huating, Chan, K C Allen, Chiu, Rossa W K, Lo, Y M Dennis, Sun, Hao

“…DNA methylation, one of the most important epigenetic modifications, plays a crucial role in various biological processes. The level of DNA methylation can be…”
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Noninvasive prenatal diagnosis of fetal trisomy 18 and trisomy 13 by maternal plasma DNA sequencing by Chen, Eric Z, Chiu, Rossa W K, Sun, Hao, Akolekar, Ranjit, Chan, K C Allen, Leung, Tak Y, Jiang, Peiyong, Zheng, Yama W L, Lun, Fiona M F, Chan, Lisa Y S, Jin, Yongjie, Go, Attie T J I, Lau, Elizabeth T, To, William W K, Leung, Wing C, Tang, Rebecca Y K, Au-Yeung, Sidney K C, Lam, Helena, Kung, Yu Y, Zhang, Xiuqing, van Vugt, John M G, Minekawa, Ryoko, Tang, Mary H Y, Wang, Jun, Oudejans, Cees B M, Lau, Tze K, Nicolaides, Kypros H, Lo, Y M Dennis

“…Massively parallel sequencing of DNA molecules in the plasma of pregnant women has been shown to allow accurate and noninvasive prenatal detection of fetal…”
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Convolutional neural network for discriminating nasopharyngeal carcinoma and benign hyperplasia on MRI by Wong, Lun M., King, Ann D., Ai, Qi Yong H., Lam, W. K. Jacky, Poon, Darren M. C., Ma, Brigette B. Y., Chan, K. C. Allen, Mo, Frankie K. F.

“…Objectives A convolutional neural network (CNN) was adapted to automatically detect early-stage nasopharyngeal carcinoma (NPC) and discriminate it from benign…”
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Methylation analysis of plasma DNA informs etiologies of Epstein-Barr virus-associated diseases by Lam, W. K. Jacky, Jiang, Peiyong, Chan, K. C. Allen, Peng, Wenlei, Shang, Huimin, Heung, Macy M. S., Cheng, Suk Hang, Zhang, Haiqiang, Tse, O. Y. Olivia, Raghupathy, Radha, Ma, Brigette B. Y., Hui, Edwin P., Chan, Anthony T. C., Woo, John K. S., Chiu, Rossa W. K., Lo, Y. M. Dennis

“…Epstein-Barr virus (EBV) is associated with a number of diseases, including malignancies. Currently, it is not known whether patients with different…”
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Cancer genome scanning in plasma: detection of tumor-associated copy number aberrations, single-nucleotide variants, and tumoral heterogeneity by massively parallel sequencing by Chan, K C Allen, Jiang, Peiyong, Zheng, Yama W L, Liao, Gary J W, Sun, Hao, Wong, John, Siu, Shing Shun N, Chan, Wing C, Chan, Stephen L, Chan, Anthony T C, Lai, Paul B S, Chiu, Rossa W K, Lo, Y M D

“…Tumor-derived DNA can be found in the plasma of cancer patients. In this study, we explored the use of shotgun massively parallel sequencing (MPS) of plasma…”
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Jagged Ends of Urinary Cell-Free DNA: Characterization and Feasibility Assessment in Bladder Cancer Detection by Zhou, Ze, Cheng, Suk Hang, Ding, Spencer C, Heung, Macy M S, Xie, Tingting, Cheng, Timothy H T, Lam, W K Jacky, Peng, Wenlei, Teoh, Jeremy Y C, Chiu, Peter K F, Ng, Chi-Fai, Jiang, Peiyong, Chan, K C Allen, Chiu, Rossa W K, Lo, Y M Dennis

“…Abstract Background Double-stranded DNA in plasma is known to carry single-stranded ends, called jagged ends. Plasma DNA jagged ends are biomarkers for…”
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Distinguishing early-stage nasopharyngeal carcinoma from benign hyperplasia using intravoxel incoherent motion diffusion-weighted MRI by Ai, Qi-Yong, King, Ann D., Chan, Janet S. M., Chen, Weitian, Chan, K. C. Allen, Woo, John K. S., Zee, Benny C. Y., Chan, Anthony T. C., Poon, Darren M. C., Ma, Brigette B. Y., Hui, Edwin P., Ahuja, Anil T., Vlantis, Alexander C., Yuan, Jing

“…Objectives MRI can detect early-stage nasopharyngeal carcinoma (NPC), but the detection is more challenging in early-stage NPCs because they must be…”
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Fragmentomics of urinary cell-free DNA in nuclease knockout mouse models by Chen, Meihui, Chan, Rebecca W. Y, Cheung, Peter P. H, Ni, Meng, Wong, Danny K. L, Zhou, Ze, Ma, Mary-Jane L, Huang, Liangbo, Xu, Xinzhou, Lee, Wing-Shan, Wang, Guangya, Lui, Kathy O, Lam, W. K. Jacky, Teoh, Jeremy Y. C, Ng, Chi-Fai, Jiang, Peiyong, Chan, K. C. Allen, Chiu, Rossa W. K, Lo, Y. M. Dennis

“…Urinary cell-free DNA (ucfDNA) is a potential biomarker for bladder cancer detection. However, the biological characteristics of ucfDNA are not well…”
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High resolution size analysis of fetal DNA in the urine of pregnant women by paired-end massively parallel sequencing by Tsui, Nancy B Y, Jiang, Peiyong, Chow, Katherine C K, Su, Xiaoxi, Leung, Tak Y, Sun, Hao, Chan, K C Allen, Chiu, Rossa W K, Lo, Y M Dennis

“…Fetal DNA in maternal urine, if present, would be a valuable source of fetal genetic material for noninvasive prenatal diagnosis. However, the existence of…”
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High-resolution profiling of fetal DNA clearance from maternal plasma by massively parallel sequencing by Yu, Stephanie C Y, Lee, Shara W Y, Jiang, Peiyong, Leung, Tak Y, Chan, K C Allen, Chiu, Rossa W K, Lo, Y M Dennis

“…With the advent of massively parallel sequencing (MPS), DNA analysis can now be performed in a genomewide manner. Recent studies have demonstrated the high…”
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Commutability of the Epstein-Barr virus WHO international standard across two quantitative PCR methods by Abeynayake, Janaki, Johnson, Ryan, Libiran, Paolo, Sahoo, Malaya K, Cao, Hongbin, Bowen, Raffick, Chan, K C Allen, Le, Quynh-Thu, Pinsky, Benjamin A

“…The commutability of international reference standards is critical for ensuring quantitative agreement across different viral load assays. Here, we demonstrate…”
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Digital PCR for the molecular detection of fetal chromosomal aneuploidy by Lo, Y.M. Dennis, Lun, Fiona M.F, Chan, K.C. Allen, Tsui, Nancy B.Y, Chong, Ka C, Lau, Tze K, Leung, Tak Y, Zee, Benny C.Y, Cantor, Charles R, Chiu, Rossa W.K

“…Trisomy 21 is the most common reason that women opt for prenatal diagnosis. Conventional prenatal diagnostic methods involve the sampling of fetal materials by…”
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Noninvasive prenatal diagnosis of fetal trisomy 21 by allelic ratio analysis using targeted massively parallel sequencing of maternal plasma DNA by Liao, Gary J W, Chan, K C Allen, Jiang, Peiyong, Sun, Hao, Leung, Tak Y, Chiu, Rossa W K, Lo, Y M Dennis

“…Plasma DNA obtained from a pregnant woman contains a mixture of maternal and fetal DNA. The fetal DNA proportion in maternal plasma is relatively consistent as…”
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Noninvasive prenatal methylomic analysis by genomewide bisulfite sequencing of maternal plasma DNA by Lun, Fiona M F, Chiu, Rossa W K, Sun, Kun, Leung, Tak Y, Jiang, Peiyong, Chan, K C Allen, Sun, Hao, Lo, Y M Dennis

“…Epigenetic mechanisms play an important role in prenatal development, but fetal tissues are not readily accessible. Fetal DNA molecules are present in maternal…”
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