Search Results - "Chan, Alfred A"

Quantitative Aggregation of Microbiome Sequencing Data Provides Insights into the Associations between the Skin Microbiome and Psoriasis by Chan, Alfred A, Tran, Patrick T, Lee, Delphine J

“…Although prior studies have reported distinct skin microbiome profiles associated with psoriasis, differences in methods and analyses limit generalizable…”
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Mycobacterium bovis Bacillus Calmette-Guérin Alters Melanoma Microenvironment Favoring Antitumor T Cell Responses and Improving M2 Macrophage Function by Lardone, Ricardo D, Chan, Alfred A, Lee, Agnes F, Foshag, Leland J, Faries, Mark B, Sieling, Peter A, Lee, Delphine J

“…Intralesional bacillus Calmette-Guérin (BCG) has long been a relatively inexpensive therapy for inoperable cutaneous metastatic melanoma (CMM), although…”
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BCG hydrogel promotes CTSS-mediated antigen processing and presentation, thereby suppressing metastasis and prolonging survival in melanoma by Kremenovic, Mirela, Chan, Alfred A, Feng, Bing, Bäriswyl, Lukas, Robatel, Steve, Gruber, Thomas, Tang, Li, Lee, Delphine J, Schenk, Mirjam

“…BackgroundThe use of intralesional Mycobacterium bovis BCG (intralesional live BCG) for the treatment of metastatic melanoma resulted in regression of directly…”
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Tocilizumab overcomes chemotherapy resistance in mesenchymal stem-like breast cancer by negating autocrine IL-1A induction of IL-6 by Chung, Andrew W., Kozielski, Anthony J., Qian, Wei, Zhou, Jianying, Anselme, Ann C., Chan, Alfred A., Pan, Ping-Ying, Lee, Delphine J., Chang, Jenny C.

“…Triple-negative breast cancer (TNBC) patients with mesenchymal stem-like (MSL) subtype have responded poorly to chemotherapy whereas patients with basal-like 1…”
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Characterization of the microbiome of nipple aspirate fluid of breast cancer survivors by Chan, Alfred A., Bashir, Mina, Rivas, Magali N., Duvall, Karen, Sieling, Peter A., Pieber, Thomas R., Vaishampayan, Parag A., Love, Susan M., Lee, Delphine J.

“…The microbiome impacts human health and disease. Until recently, human breast tissue and milk were presumed to be sterile. Here, we investigated the presence…”
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A phase 1/2 clinical trial of the nitric oxide synthase inhibitor L-NMMA and taxane for treating chemoresistant triple-negative breast cancer by Chung, Andrew W, Anand, Kartik, Anselme, Ann C, Chan, Alfred A, Gupta, Nakul, Venta, Luz A, Schwartz, Mary R, Qian, Wei, Xu, Yitian, Zhang, Licheng, Kuhn, John, Patel, Tejal, Rodriguez, Angel A, Belcheva, Anna, Darcourt, Jorge, Ensor, Joe, Bernicker, Eric, Pan, Ping-Ying, Chen, Shu Hsia, Lee, Delphine J, Niravath, Polly A, Chang, Jenny C

“…The inducible nitric oxide signaling (iNOS) pathway is associated with poor prognosis in triple-negative breast cancer (TNBC). Prior studies using in vivo…”
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Hidradenitis suppurativa through the lens of YouTube: A cross-sectional analysis by Li, Wendy, Ma, Janice E., Chan, Alfred A., Lee, Delphine J., Smogorzewski, Jan

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Alcohol and Smoking Cessation as Potential Modulators for Smoking-Associated Psoriasis Risk in Postmenopausal Women: The Women’s Health Initiative by Li, Wendy, Chan, Alfred A., Han, Jiali, Chlebowski, Rowan T., Lee, Delphine J.

“…Background The association of alcohol with psoriasis has been inconsistent among studies. Objectives We aimed (1) to determine whether alcohol consumption (by…”
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Association between baseline insulin resistance and psoriasis incidence: the Women’s Health Initiative by Chan, Alfred A., Li, Houmin, Li, Wendy, Pan, Kathy, Yee, Jennifer K., Chlebowski, Rowan T., Lee, Delphine J.

“…Small-scale studies offer conflicting evidence regarding the relationship/association between psoriasis and insulin resistance by HOMA-IR (homeostasis model…”
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Interaction of body mass index or waist‐to‐hip ratio and sun exposure associated with nonmelanoma skin cancer: A prospective study from the Women’s Health Initiative by Chan, Alfred A., Noguti, Juliana, Pak, Youngju, Qi, Lihong, Caan, Bette, Going, Scott, Han, Jiali, Chlebowski, Rowan T., Lee, Delphine J.

“…Background The incidence of nonmelanoma skin cancer (NMSC) exceeds the incidence of all other types of cancers combined. Cumulative sun exposure and…”
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Characterization of a Myeloid Activation Signature that Correlates with Survival in Melanoma Patients by Kremenovic, Mirela, Rombini, Nives, Chan, Alfred A, Gruber, Thomas, Bäriswyl, Lukas, Lee, Delphine J, Schenk, Mirjam

“…Understanding the cellular interactions within the tumor microenvironment (TME) of melanoma paved the way for novel therapeutic modalities, such as T…”
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The Effect of Systemic Antibiotics for Suppurative Skin and Soft Tissue Infections on the Skin Microbiome by Chan, Alfred A, Flores, Evelyn A, Navarrete, Marian, Phan Tran, Donna, Lee, Delphine J, Miller, Loren G

“…Abstract Background Skin and soft tissue infections (SSTIs) are very common bacterial infections. There are few data on the microbiome of persons with and…”
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N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma by Geroyska, Sofia, Mejia, Isabel, Chan, Alfred A, Navarrete, Marian, Pandey, Vijaya, Kharpatin, Samuel, Noguti, Juliana, Wang, Feng, Srole, Daniel, Chou, Tsui-Fen, Wohlschlegel, James, Nemeth, Elizabeta, Damoiseaux, Robert, Shackelford, David B, Lee, Delphine J, Díaz, Begoña

“…Myristoylation is a type of protein acylation by which the fatty acid myristate is added to the N-terminus of target proteins, a process mediated by…”
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Both the intratumoral immune and microbial microenvironment are linked to recurrence in human colon cancer: results from a prospective, multicenter nodal ultrastaging trial by Noguti, Juliana, Chan, Alfred A, Bandera, Bradley, Brislawn, Colin J, Protic, Mladjan, Sim, Myung S, Jansson, Janet K, Bilchik, Anton J, Lee, Delphine J

“…Colon cancer (CC) is the third most common cancer diagnosed in the United States and the incidence has been rising among young adults. We and others have shown…”
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Insights into Local Tumor Microenvironment Immune Factors Associated with Regression of Cutaneous Melanoma Metastases by Mycobacterium bovis Bacille Calmette-Guérin by Yang, Junbao, Jones, Maris S, Ramos, Romela Irene, Chan, Alfred A, Lee, Agnes F, Foshag, Leland J, Sieling, Peter A, Faries, Mark B, Lee, Delphine J

“…bacille Calmette-Guérin (BCG) is listed as an intralesional (IL) therapeutic option for inoperable stage III in-transit melanoma in the National Comprehensive…”
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