Search Results - "Chan"

PNPLA3 gene polymorphism accounts for fatty liver in community subjects without metabolic syndrome by Shen, J., Wong, G. L.‐H., Chan, H. L.‐Y., Chan, H.‐Y., Yeung, D. K.‐W., Chan, R. S.‐M., Chim, A. M.‐L., Chan, A. W.‐H., Choi, P. C.‐L., Woo, J., Chu, W. C.‐W., Wong, V. W.‐S.

“…Summary Background The rs738409 GG variant in patatin‐like phospholipase 3 (PNPLA3) is associated with non‐alcoholic fatty liver disease (NAFLD) and disease…”
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Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients by Jiang, Peiyong, Chan, Carol W. M., Chan, K. C. Allen, Cheng, Suk Hang, Wong, John, Wong, Vincent Wai-Sun, Wong, Grace L. H., Chan, Stephen L., Mok, Tony S. K., Chan, Henry L. Y., Lai, Paul B. S., Chiu, Rossa W. K., Lo, Y. M. Dennis

“…Significance We used massively parallel sequencing to study the size profiles of plasma DNA samples at single-base resolution and in a genome-wide manner. We…”
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Noninvasive detection of cancer-associated genome-wide hypomethylation and copy number aberrations by plasma DNA bisulfite sequencing by Chan, K. C. Allen, Jiang, Peiyong, Chan, Carol W. M., Sun, Kun, Wong, John, Hui, Edwin P., Chan, Stephen L., Chan, Wing Cheong, Hui, David S. C., Ng, Simon S. M., Chan, Henry L. Y., Wong, Cesar S. C., Ma, Brigette B. Y., Chan, Anthony T. C., Lai, Paul B. S., Sun, Hao, Chiu, Rossa W. K., Lo, Y. M. Dennis

“…We explored the detection of genome-wide hypomethylation in plasma using shotgun massively parallel bisulfite sequencing as a marker for cancer…”
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Cancer genome scanning in plasma: detection of tumor-associated copy number aberrations, single-nucleotide variants, and tumoral heterogeneity by massively parallel sequencing by Chan, K C Allen, Jiang, Peiyong, Zheng, Yama W L, Liao, Gary J W, Sun, Hao, Wong, John, Siu, Shing Shun N, Chan, Wing C, Chan, Stephen L, Chan, Anthony T C, Lai, Paul B S, Chiu, Rossa W K, Lo, Y M D

“…Tumor-derived DNA can be found in the plasma of cancer patients. In this study, we explored the use of shotgun massively parallel sequencing (MPS) of plasma…”
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Systematic evaluation of circulating inflammatory markers for hepatocellular carcinoma by Chan, Stephen L., Chan, Anthony W.H., Chan, Allen K.C., Jian, Peiyong, Mo, Frankie, Chan, Charles M.L., Mok, Kevin, Liu, Calvin, Chong, Charing C.N., Chan, Anthony T.C., Mok, Tony, Yeo, Winnie

“…Backgrounds & Aims A number of circulating inflammatory factors are implicated in the pathogenesis and prognostication of hepatocellular carcinoma (HCC). We…”
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Pain Relief After Total Knee Arthroplasty with Intravenous and Periarticular Corticosteroid: A Randomized Controlled Trial by Chan, P.K., Chan, T.C.W., Mak, C.Y.H., Chan, T.H.M., Chan, S.H.W., Wong, S.S.C., Fu, H., Cheung, A., Chan, V.W.K., Cheung, M.H., Cheung, C.W., Chiu, K.Y.

“…Total knee arthroplasty (TKA) is a cost-effective procedure, but it is also associated with substantial postoperative pain. The present study aimed to compare…”
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Alanine aminotransferase-based algorithms of liver stiffness measurement by transient elastography (Fibroscan) for liver fibrosis in chronic hepatitis B by Chan, H. L.-Y., Wong, G. L.-H., Choi, P. C.-L., Chan, A. W.-H., Chim, A. M.-L., Yiu, K. K.-L., Chan, F. K.-L., Sung, J. J.-Y., Wong, V. W.-S.

“…The aim of this study is to know the liver stiffness measurement (LSM) cutoffs for different stages of liver fibrosis in chronic hepatitis B (CHB) and to…”
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Analysis of Plasma Epstein–Barr Virus DNA to Screen for Nasopharyngeal Cancer by Chan, K.C. Allen, Woo, John K.S, King, Ann, Zee, Benny C.Y, Lam, W.K. Jacky, Chan, Stephen L, Chu, Sam W.I, Mak, Constance, Tse, Irene O.L, Leung, Samantha Y.M, Chan, Gloria, Hui, Edwin P, Ma, Brigette B.Y, Chiu, Rossa W.K, Leung, Sing-Fai, van Hasselt, Andrew C, Chan, Anthony T.C, Lo, Y.M. Dennis

“…Circulating Epstein–Barr virus DNA was measured in 20,174 asymptomatic participants in Hong Kong; 34 of 309 with positive results had nasopharyngeal cancer…”
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Timing of Endoscopy for Acute Upper Gastrointestinal Bleeding by Lau, James Y.W, Yu, Yuanyuan, Tang, Raymond S.Y, Chan, Heyson C.H, Yip, Hon-Chi, Chan, Shannon M, Luk, Sally W.Y, Wong, Sunny H, Lau, Louis H.S, Lui, Rashid N, Chan, Ting T, Mak, Joyce W.Y, Chan, Francis K.L, Sung, Joseph J.Y

“…Patients with acute upper gastrointestinal bleeding were assigned to receive endoscopy within 6 hours or between 6 and 24 hours after gastroenterologic…”
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Gut microbiome dysbiosis across early Parkinson’s disease, REM sleep behavior disorder and their first-degree relatives by Huang, Bei, Chau, Steven W. H., Liu, Yaping, Chan, Joey W. Y., Wang, Jing, Ma, Suk Ling, Zhang, Jihui, Chan, Paul K. S., Yeoh, Yun Kit, Chen, Zigui, Zhou, Li, Wong, Sunny Hei, Mok, Vincent C. T., To, Ka Fai, Lai, Hei Ming, Ng, Simon, Trenkwalder, Claudia, Chan, Francis K. L., Wing, Yun Kwok

“…The microbiota-gut-brain axis has been suggested to play an important role in Parkinson’s disease (PD). Here we performed a cross-sectional study to profile…”
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Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments by Sun, Kun, Jiang, Peiyong, Chan, K. C. Allen, Wong, John, Cheng, Yvonne K. Y., Liang, Raymond H. S., Chan, Wai-kong, Ma, Edmond S. K., Chan, Stephen L., Cheng, Suk Hang, Chan, Rebecca W. Y., Tong, Yu K., Ng, Simon S. M., Wong, Raymond S. M., Hui, David S. C., Leung, Tse Ngong, Leung, Tak Y., Lai, Paul B. S., Chiu, Rossa W. K., Lo, Yuk Ming Dennis

“…Plasma consists of DNA released from multiple tissues within the body. Using genome-wide bisulfite sequencing of plasma DNA and deconvolution of the sequencing…”
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A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening by Yan, Helen H.N., Siu, Hoi Cheong, Law, Simon, Ho, Siu Lun, Yue, Sarah S.K., Tsui, Wai Yin, Chan, Dessy, Chan, April S., Ma, Stephanie, Lam, Ka On, Bartfeld, Sina, Man, Alice H.Y., Lee, Bernard C.H., Chan, Annie S.Y., Wong, Jason W.H., Cheng, Priscilla S.W., Chan, Anthony K.W., Zhang, Jiangwen, Shi, Jue, Fan, Xiaodan, Kwong, Dora L.W., Mak, Tak W., Yuen, Siu Tsan, Clevers, Hans, Leung, Suet Yi

“…Gastric cancer displays marked molecular heterogeneity with aggressive behavior and treatment resistance. Therefore, good in vitro models that encompass unique…”
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Detection and characterization of jagged ends of double-stranded DNA in plasma by Jiang, Peiyong, Xie, Tingting, Ding, Spencer C, Zhou, Ze, Cheng, Suk Hang, Chan, Rebecca W Y, Lee, Wing-Shan, Peng, Wenlei, Wong, John, Wong, Vincent W S, Chan, Henry L Y, Chan, Stephen L, Poon, Liona C Y, Leung, Tak Y, Chan, K C Allen, Chiu, Rossa W K, Lo, Y M Dennis

“…Cell-free DNA in plasma has been used for noninvasive prenatal testing and cancer liquid biopsy. The physical properties of cell-free DNA fragments in plasma,…”
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Evolution of treatment for nasopharyngeal cancer – Success and setback in the intensity-modulated radiotherapy era by Lee, Anne W.M, Ng, Wai Tong, Chan, Lucy L.K, Hung, Wai Man, Chan, Connie C.C, Sze, Henry C.K, Chan, Oscar S.H, Chang, Amy T.Y, Yeung, Rebecca M.W

“…Abstract Background and purpose To assess the therapeutic gains and setbacks as we evolved from the 2-dimensional radiotherapy (2DRT) to conformal…”
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Suicide in Hong Kong: a case-control psychological autopsy study by Chen, Eric Y H, Chan, Wincy S C, Wong, Paul W C, Chan, Sandra S M, Chan, Cecilia L W, Law, Y W, Beh, Philip S L, Chan, K K, Cheng, Joanne W Y, Liu, Ka Y, Yip, Paul S F

“…The relative contribution of psychosocial and clinical risk factors to suicide among Chinese populations is an important issue. In Hong Kong, this issue…”
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Simulation of the Clinical and Pathological Manifestations of Coronavirus Disease 2019 (COVID-19) in a Golden Syrian Hamster Model: Implications for Disease Pathogenesis and Transmissibility by Chan, Jasper Fuk-Woo, Zhang, Anna Jinxia, Yuan, Shuofeng, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Lee, Andrew Chak-Yiu, Chan, Wan-Mui, Fan, Zhimeng, Tsoi, Hoi-Wah, Wen, Lei, Liang, Ronghui, Cao, Jianli, Chen, Yanxia, Tang, Kaiming, Luo, Cuiting, Cai, Jian-Piao, Kok, Kin-Hang, Chu, Hin, Chan, Kwok-Hung, Sridhar, Siddharth, Chen, Zhiwei, Chen, Honglin, To, Kelvin Kai-Wang, Yuen, Kwok-Yung

“…Abstract Background A physiological small-animal model that resembles COVID-19 with low mortality is lacking. Methods Molecular docking on the binding between…”
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Orientation-aware plasma cell-free DNA fragmentation analysis in open chromatin regions informs tissue of origin by Sun, Kun, Jiang, Peiyong, Cheng, Suk Hang, Cheng, Timothy H T, Wong, John, Wong, Vincent W S, Ng, Simon S M, Ma, Brigette B Y, Leung, Tak Y, Chan, Stephen L, Mok, Tony S K, Lai, Paul B S, Chan, Henry L Y, Sun, Hao, Chan, K C Allen, Chiu, Rossa W K, Lo, Y M Dennis

“…Cell-free DNA (cfDNA) in human plasma is a class of biomarkers with many current and potential future diagnostic applications. Recent studies have shown that…”
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Bacterial endotoxin and non‐alcoholic fatty liver disease in the general population: a prospective cohort study by Wong, V. W.‐S., Wong, G. L.‐H., Chan, H.‐Y., Yeung, D. K.‐W., Chan, R. S.‐M., Chim, A. M.‐L., Chan, C. K.‐M., Tse, Y.‐K., Woo, J., Chu, W. C.‐W., Chan, H. L.‐Y.

“…Summary Background Patients with non‐alcoholic steatohepatitis (NASH) have increased intestinal permeability and small intestine bacterial overgrowth. Aims To…”
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Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant by Sera From BNT162b2 or CoronaVac Vaccine Recipients by Lu, Lu, Mok, Bobo Wing Yee, Chen, Lin Lei, Chan, Jacky Man Chun, Tsang, Owen Tak Yin, Lam, Bosco Hoi Shiu, Chuang, Vivien Wai Man, Chu, Allen Wing Ho, Chan, Wan Mui, Ip, Jonathan Daniel, Chan, Brian Pui Chun, Zhang, Ruiqi, Yip, Cyril Chik Yan, Cheng, Vincent Chi Chung, Chan, Kwok Hung, Jin, Dong Yan, Hung, Ivan Fan Ngai, Yuen, Kwok Yung, Chen, Honglin, To, Kelvin Kai Wang

“…Abstract Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron variant, designated as a variant of concern by the World Health…”
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Quality-of-life among head and neck cancer survivors at one year after treatment – A systematic review by So, W.K.W, Chan, R.J, Chan, D.N.S, Hughes, B.G.M, Chair, S.Y, Choi, K.C, Chan, C.W.H

“…Abstract Background The importance of quality-of-life (QoL) research has been recognised over the past two decades in patients with head and neck (H&N) cancer…”
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