Advanced Molecular Imaging (MRI/MRS/1H NMR) for Metabolic Information in Young Adults with Health Risk Obesity

Advanced Molecular Imaging (MRI/MRS/1H NMR) for Metabolic Information in Young Adults with Health Risk Obesity

Background: Obesity or being overweight is a medical condition of abnormal body fat accumulation which is associated with a higher risk of developing metabolic syndrome. The distinct body fat depots on specific parts of the anatomy have unique metabolic properties and different types of regional exc...

Full description

Saved in:
Bibliographic Details
Published in:Life (Basel, Switzerland) Vol. 11; no. 10; p. 1035
Main Authors: Htun, Khin Thandar, Pan, Jie, Pasanta, Duanghathai, Tungjai, Montree, Udomtanakunchai, Chatchanok, Petcharoen, Thanaporn, Chamta, Nattacha, Kosicharoen, Supak, Chukua, Kiattisak, Lai, Christopher, Kothan, Suchart
Format: Journal Article
Language:English
Published: Basel MDPI AG 01-10-2021
MDPI
Subjects:
1H NMR
Abdomen
Adults
Biomarkers
Blood
Body fat
Body weight
Cholesterol
Diabetes mellitus
Dyslipidemia
Glucose
Glucose metabolism
Health risks
Hemoglobin
Hepatocytes
Hyperglycemia
Insulin resistance
Lipid metabolism
Lipids
Liver
Magnetic resonance imaging
Magnetic resonance spectroscopy
Medical imaging
Metabolic disorders
Metabolic syndrome
Metabolites
MRI
MRS
Muscles
NMR
NMR spectroscopy
Nuclear magnetic resonance
Obesity
Phenotypes
Spectroscopy
Statistical analysis
Triglycerides
Young adults
Thailand
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Obesity or being overweight is a medical condition of abnormal body fat accumulation which is associated with a higher risk of developing metabolic syndrome. The distinct body fat depots on specific parts of the anatomy have unique metabolic properties and different types of regional excessive fat distribution can be a disease hazard. The aim of this study was to identify the metabolome and molecular imaging phenotypes among a young adult population. Methods: The amount and distribution of fat and lipid metabolites profile in the abdomen, liver, and calf muscles of 46 normal weight, 17 overweight, and 13 obese participants were acquired using MRI and MR spectroscopy (MRS), respectively. The serum metabolic profile was obtained using proton NMR spectroscopy. NMR spectra were integrated into seven integration regions, which reflect relative metabolites. Results: A significant metabolic disorder symptom appeared in the overweight and obese group, and increased lipid deposition occurred in the abdomen, hepatocytes, and muscles that were statistically significant. Overall, the visceral fat depots had a marked influence on dyslipidemia biomarkers, blood triglyceride (r = 0.592, p < 0.001), and high-density lipoprotein cholesterol (r = −0.484, p < 0.001). Intrahepatocellular lipid was associated with diabetes predictors for hemoglobin (HbA1c%; r = 0.379, p < 0.001) and for fasting blood sugar (r = 0.333, p < 0.05). The lipid signals in serum triglyceride and glucose signals gave similar correspondence to biochemical lipid profiles. Conclusions: This study proves the association between alteration in metabolome in young adults, which is the key population for early prevention of obesity and metabolic syndrome. This study suggests that dyslipidemia prevalence is influenced mainly by the visceral fat depot, and liver fat depot is a key determinant for glucose metabolism and hyperglycemia. Moreover, noninvasive advanced molecular imaging completely elucidated the impact of fat distribution on the anthropometric and laboratory parameters, especially indices of the metabolic syndrome biomarkers in young adults.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2075-1729
2075-1729
DOI:10.3390/life11101035