Search Results - "Champoux, J. J."

DNA TOPOISOMERASES: Structure, Function, and Mechanism by Champoux, James J

“…DNA topoisomerases solve the topological problems associated with DNA replication, transcription, recombination, and chromatin remodeling by introducing…”
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Effects of DNA and protein size on substrate cleavage by human tyrosyl-DNA phosphodiesterase 1 by Interthal, Heidrun, Champoux, James J

“…TDP (tyrosyl-DNA phosphodiesterase) 1 catalyses the hydrolysis of phosphodiester linkages between a DNA 3' phosphate and a tyrosine residue as well as a…”
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Human Tdp1 Cleaves a Broad Spectrum of Substrates, Including Phosphoamide Linkages by Interthal, Heidrun, Chen, Hong Jing, Champoux, James J.

“…Human tyrosyl-DNA phosphodiesterase (Tdp1) hydrolyzes the phosphodiester bond between a DNA 3′ end and a tyrosyl moiety. In eukaryotic cells, this type of…”
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The Tyrosyl-DNA Phosphodiesterase Tdp1 is a Member of the Phospholipase D Superfamily by Interthal, Heidrun, Pouliot, Jeffrey J., Champoux, James J.

“…The phospholipase D (PLD) superfamily is a diverse group of proteins that includes enzymes involved in phospholipid metabolism, a bacterial toxin, poxvirus…”
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RNase H activity: Structure, specificity, and function in reverse transcription by Schultz, Sharon J., Champoux, James J.

“…This review compares the well-studied RNase H activities of human immunodeficiency virus, type 1 (HIV-1) and Moloney murine leukemia virus (MoMLV) reverse…”
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Human DNA topoisomerase I: relaxation, roles, and damage control by Leppard, John B, Champoux, James J

“…Human DNA topoisomerase I is an essential enzyme involved in resolving the torsional stress associated with DNA replication, transcription, and chromatin…”
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A Model for the Mechanism of Human Topoisomerase I by Stewart, Lance, Redinbo, Matthew R., Qui, Xiayang, Wim G. J. Hol, Champoux, James J.

“…The three-dimensional structure of a 70-kilodalton amino terminally truncated form of human topoisomerase I in complex with a 22-base pair duplex…”
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Ribonuclease H: properties, substrate specificity and roles in retroviral reverse transcription by Champoux, James J, Schultz, Sharon J

“…Retroviral reverse transcriptases possess both a DNA polymerase and an RNase H activity. The linkage with the DNA polymerase activity endows the retroviral…”
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Crystal Structures of Human Topoisomerase I in Covalent and Noncovalent Complexes with DNA by Redinbo, Matthew R., Stewart, Lance, Kuhn, Peter, Champoux, James J., Wim G. J. Hol

“…Topoisomerases I promote the relaxation of DNA superhelical tension by introducing a transient single-stranded break in duplex DNA and are vital for the…”
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SCAN1 mutant Tdp1 accumulates the enzyme-DNA intermediate and causes camptothecin hypersensitivity by Interthal, Heidrun, Chen, Hong Jing, Kehl-Fie, Thomas E, Zotzmann, Jörg, Leppard, John B, Champoux, James J

“…Tyrosyl‐DNA phosphodiesterase (Tdp1) catalyzes the hydrolysis of the tyrosyl‐3′ phosphate linkage found in topoisomerase I–DNA covalent complexes. The…”
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The Structure of the Transition State of the Heterodimeric Topoisomerase I of Leishmania donovani as a Vanadate Complex with Nicked DNA by Davies, Douglas R., Mushtaq, Adeel, Interthal, Heidrun, Champoux, James J., Hol, Wim G.J.

“…Type IB topoisomerases are essential enzymes that are responsible for relaxing superhelical tension in DNA by forming a transient covalent nick in one strand…”
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The Crystal Structure of Human Tyrosyl-DNA Phosphodiesterase, Tdp1 by Davies, Douglas R, Interthal, Heidrun, Champoux, James J, Hol, Wim G.J

“…Tyrosyl-DNA phosphodiesterase (Tdp1) catalyzes the hydrolysis of a phosphodiester bond between a tyrosine residue and a DNA 3′ phosphate. The enzyme appears to…”
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Pausing during Reverse Transcription Increases the Rate of Retroviral Recombination by LANCIAULT, Christian, CHAMPOUX, James J

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Insights into Substrate Binding and Catalytic Mechanism of Human Tyrosyl-DNA Phosphodiesterase (Tdp1) from Vanadate and Tungstate-inhibited Structures by Davies, Douglas R., Interthal, Heidrun, Champoux, James J., Hol, Wim G.J.

“…Tyrosyl-DNA phosphodiesterase (Tdp1) is a DNA repair enzyme that catalyzes the hydrolysis of a phosphodiester bond between a tyrosine residue and a DNA…”
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Structure-Based Analysis of the Effects of Camptothecin on the Activities of Human Topoisomerase I by CHAMPOUX, JAMES J.

“…: The sole target for the anticancer drug camptothecin (CPT) is the type I topoisomerase. The drug poisons the topoisomerase by slowing the religation step of…”
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Mutational analysis of the preferential binding of human topoisomerase I to supercoiled DNA by Yang, Zheng, Carey, James F, Champoux, James J

“…Human topoisomerase I binds DNA in a topology-dependent fashion with a strong preference for supercoiled DNAs of either sign over relaxed circular DNA. One…”
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Preferred Sequences within a Defined Cleavage Window Specify DNA 3′ End-directed Cleavages by Retroviral RNases H by Schultz, Sharon J., Zhang, Miaohua, Champoux, James J.

“…The RNase H activity of reverse transcriptase carries out three types of cleavage termed internal, RNA 5′ end-directed, and DNA 3′ end-directed. Given the…”
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Novel Insights into Catalytic Mechanism from a Crystal Structure of Human Topoisomerase I in Complex with DNA by Redinbo, Matthew R, Champoux, James J, Hol, Wim G. J

“…Human topoisomerase I helps to control the level of DNA supercoiling in cells and is vital for numerous DNA metabolic events, including replication,…”
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Sequence, Distance, and Accessibility Are Determinants of 5′-End-directed Cleavages by Retroviral RNases H by Schultz, Sharon J., Zhang, Miaohua, Champoux, James J.

“…The RNase H activity of reverse transcriptase is essential for retroviral replication. RNA 5′-end-directed cleavages represent a form of RNase H activity that…”
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DNA topoisomerase I is involved in both repression and activation of transcription by Merino, Alejandro, Madden, Knut R, Lane, William S, Champoux, James J, Reinberg, Danny

“…Reconstituted transcription reactions containing the seven general transcription factors, in addition to RNA polymerase II, respond poorly to transcriptional…”
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