Search Results - "Champion, Cheryl I"

A vault nanoparticle vaccine induces protective mucosal immunity by Champion, Cheryl I, Kickhoefer, Valerie A, Liu, Guangchao, Moniz, Raymond J, Freed, Amanda S, Bergmann, Liisa L, Vaccari, Dana, Raval-Fernandes, Sujna, Chan, Ann M, Rome, Leonard H, Kelly, Kathleen A

“…Generation of robust cell-mediated immune responses at mucosal surfaces while reducing overall inflammation is a primary goal for vaccination. Here we report…”
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Interruption of CXCL13-CXCR5 axis increases upper genital tract pathology and activation of NKT cells following chlamydial genital infection by Jiang, Janina, Karimi, Ouafae, Ouburg, Sander, Champion, Cheryl I, Khurana, Archana, Liu, Guangchao, Freed, Amanda, Pleijster, Jolein, Rozengurt, Nora, Land, Jolande A, Surcel, Helja-Marja, Tiitinen, Aila', Paavonen, Jorma, Kronenberg, Mitchell, Morré, Servaas A, Kelly, Kathleen A

“…Regulation of immune responses is critical for controlling inflammation and disruption of this process can lead to tissue damage. We reported that CXCL13 was…”
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Vault nanocapsules as adjuvants favor cell-mediated over antibody-mediated immune responses following immunization of mice by Kar, Upendra K, Jiang, Janina, Champion, Cheryl I, Salehi, Sahar, Srivastava, Minu, Sharma, Sherven, Rabizadeh, Shahrooz, Niazi, Kayvan, Kickhoefer, Valerie, Rome, Leonard H, Kelly, Kathleen A

“…Modifications of adjuvants that induce cell-mediated over antibody-mediated immunity is desired for development of vaccines. Nanocapsules have been found to be…”
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Temporal Analysis of the Antigenic Composition of Borrelia burgdorferi during Infection in Rabbit Skin by CROTHER, Timothy R, CHAMPION, Cheryl I, WHITELEGGE, Julian P, AGUILERA, Rodrigo, WU, Xiao-Yang, BLANCO, David R, MILLER, James N, LOVETT, Michael A

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Antigenic Composition of Borrelia burgdorferi during Infection of SCID Mice by CROTHER, Timothy R, CHAMPION, Cheryl I, WU, Xiao-Yang, BLANCO, David R, MILLER, James N, LOVETT, Michael A

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CD8^+CXCR5^+ T Cells Regulate Pathology in the Genital Tract by Jiang, Janina, Champion, Cheryl I., Wei, Bo, Liu, Guangchao, Kelly, Kathleen A.

“…We have identified a CD8+CXCR5+ T cell that prevents the development of oviduct dilation following C. muridarum genital infection. Phenotypic studies show that…”
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Monoclonal Antibody That Conveys In Vitro Killing and Partial Protection in Experimental Syphilis Binds a Phosphorylcholine Surface Epitope of Treponema pallidum by Blanco, David R, Champion, Cheryl I, Dooley, Alek, Cox, David L, Whitelegge, Julian P, Faull, Kym, Lovett, Michael A

“…Immunization with purified Treponema pallidum outer membrane vesicles (OMV) has previously resulted in high-titer complement-dependent serum bactericidal…”
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Quantitative Assessment of Protection in Experimental Syphilis by Champion, Cheryl I, Blanco, David R, Lovett, Michael A

“…Protection in experimental rabbit syphilis has been previously assessed by lesion development following intradermal challenge with Treponema pallidum. We have…”
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Correction: Interruption of CXCL13-CXCR5 Axis Increases Upper Genital Tract Pathology and Activation of NKT Cells following Chlamydial Genital Infection by Jiang, Janina, Karimi, Ouafae, Ouburg, Sander, Champion, Cheryl I., Khurana, Archana, Liu, Guangchao, Freed, Amanda, Pleijster, Jolein, Rozengurt, Nora, Land, Jolande A., Surcel, Helja-Marja, Tiitinen, Aila', Paavonen, Jorma, Kronenberg, Mitchell, Morré, Servaas A., Kelly, Kathleen A.

“…The work was sponsored by grants from the National Institutes of Health, AI026238 (KAK) and AI45053 (MK); Iris Cantor-UCLA Women's Health Center Executive…”
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Use of the skin protection assay in experimental syphilis to assess protective immunity against a specific Treponema pallidum surface epitope by Blanco, David R., Champion, Cheryl I., Lovett, Michael A.

“…We have recently shown that a monoclonal antibody, designated M131, that binds a surface phosphorylcholine epitope on Treponema pallidum possesses…”
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Comparison of Protection in Rabbits against Host-Adapted and Cultivated Borrelia burgdorferi following Infection-Derived Immunity or Immunization with Outer Membrane Vesicles or Outer Surface Protein A by SHANG, E. S, CHAMPION, C. I, WU, X.-Y, SKARE, J. T, BLANCO, D. R, MILLER, J. N, LOVETT, M. A

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Immunization with Treponema pallidum Outer Membrane Vesicles Induces High-Titer Complement-Dependent Treponemicidal Activity and Aggregation of T. pallidum Rare Outer Membrane Proteins (TROMPs) by Blanco, David R, Champion, Cheryl I, Lewinski, Michael A, Shang, Ellen S, Simkins, Stephen G, Miller, James N, Lovett, Michael A

“…The purpose of this study was to determine whether immunization with purified outer membrane vesicles (OMV) from Treponema pallidum (T.p. ) could elicit Abs…”
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Porin activity of the native and recombinant outer membrane protein Oms28 of Borrelia burgdorferi by Skare, J T, Champion, C I, Mirzabekov, T A, Shang, E S, Blanco, D R, Erdjument-Bromage, H, Tempst, P, Kagan, B L, Miller, J N, Lovett, M A

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Renaturation of Recombinant Treponema pallidum Rare Outer Membrane Protein 1 into a Trimeric, Hydrophobic, and Porin-Active Conformation by Zhang, H H, Blanco, D R, Exner, M M, Shang, E S, Champion, C I, Phillips, M L, Miller, J N, Lovett, M A

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Sequence analysis and recombinant expression of a 28-kilodalton Treponema pallidum subsp. pallidum rare outer membrane protein (Tromp2) by Champion, C I, Blanco, D R, Exner, M M, Erdjument-Bromage, H, Hancock, R E, Tempst, P, Miller, J N, Lovett, M A

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CD8^sup +^ CXCR5^sup +^ T Cells Regulate Pathology in the Genital Tract by Jiang, Janina, Champion, Cheryl I, Wei, Bo, Liu, Guangchao, Kelly, Kathleen A

“…We have identified a CD8^sup +^CXCR5^sup +^ T cell that prevents the development of oviduct dilation following C. muridarum genital infection. Phenotypic…”
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Treponemicidal antibody measured by the "washed-killing" assay correlates with immunity in experimental rabbit syphilis by Lewinski, M A, Miller, J N, Champion, C I, Walker, E M, Borenstein, L A, Gayek, R J, Lovett, M A, Blanco, D R

“…The authors have previously shown that complement-dependent treponemicidal antibody measured by the "washed-killing" assay is directed exclusively against…”
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Correction: Interruption of CXCL13-CXCR5 Axis Increases Upper Genital Tract Pathology and Activation of NKT Cells following Chlamydial Genital Infection by Janina Jiang, Ouafae Karimi, Sander Ouburg, Cheryl I. Champion, Archana Khurana, Guangchao Liu, Amanda Freed, Jolein Pleijster, Nora Rozengurt, Jolande A. Land, Helja-Marja Surcel, Aila' Tiitinen, Jorma Paavonen, Mitchell Kronenberg, Servaas A. Morré, Kathleen A. Kelly

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Virulent strain associated outer membrane proteins of Borrelia burgdorferi by Skare, J T, Shang, E S, Foley, D M, Blanco, D R, Champion, C I, Mirzabekov, T, Sokolov, Y, Kagan, B L, Miller, J N, Lovett, M A

“…We have isolated and purified outer membrane vesicles (OMV) from Borrelia burgdorferi strain B31 based on methods developed for isolation of Treponema pallidum…”
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Molecular cloning and sequence analysis of the gene encoding OmpL1, a transmembrane outer membrane protein of pathogenic Leptospira spp by HAAKE, D. A, CHAMPION, C. I, MARTINICH, C, SHANG, E. S, BLANCO, D. R, MILLER, J. N, LOVETT, M. A

“…Pathogenic Leptospira spp. are spirochetes that have a low transmembrane outer membrane protein content relative to that of enteric gram-negative bacteria. In…”
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