Search Results - "Champigny, Guy"

A proton-gated cation channel involved in acid-sensing by Waldmann, Rainer, Champigny, Guy, Bassilana, Frédéric, Heurteaux, Catherine, Lazdunski, Michel

“…Acid-sensing is associated with both nociception and taste transduction. Stimulation of sensory neurons by acid is of particular interest, because acidosis…”
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Isolation of a Tarantula Toxin Specific for a Class of Proton-gated Na+ Channels by Escoubas, Pierre, De Weille, Jan R., Lecoq, Alain, Diochot, Sylvie, Waldmann, Rainer, Champigny, Guy, Moinier, Danielle, Ménez, André, Lazdunski, Michel

“…Acid sensing is associated with nociception, taste transduction, and perception of extracellular pH fluctuations in the brain. Acid sensing is carried out by…”
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Zn2+ and H+ Are Coactivators of Acid-sensing Ion Channels by Baron, Anne, Schaefer, Lionel, Lingueglia, Eric, Champigny, Guy, Lazdunski, Michel

“…Acid-sensing ion channels (ASICs) are cationic channels activated by extracellular protons. They are expressed in sensory neurons, where they are thought to be…”
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Molecular Cloning of a Non-inactivating Proton-gated Na+ Channel Specific for Sensory Neurons by Waldmann, Rainer, Bassilana, Frédéric, de Weille, Jan, Champigny, Guy, Heurteaux, Catherine, Lazdunski, Michel

“…We have cloned and expressed a novel proton-gated Na+ channel subunit that is specific for sensory neurons. In COS cells, it forms a Na+ channel that responds…”
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Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel by Lingueglia, Eric, Champigny, Guy, Lazdunski, Michel, Barbry, Pascal

“…The peptide Phe-Met-Arg-Phe-NH2 (FMRFamide) and structurally related peptides are present both in invertebrate and vertebrate nervous systems. Although they…”
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The Mammalian Degenerin MDEG, an Amiloride-sensitive Cation Channel Activated by Mutations Causing Neurodegeneration in Caenorhabditis elegans by Waldmann, R, Champigny, G, Voilley, N, Lauritzen, I, Lazdunski, M

“…Mutations of the degenerins (deg-1, mec-4, mec-10) are the major known causes of hereditary neurodegeneration in the nematode Caenorhabditis elegans . We…”
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Molecular Cloning and Functional Expression of a Novel Amiloride-sensitive Na Channel by Waldmann, R, Champigny, G, Bassilana, F, Voilley, N, Lazdunski, M

“…We have isolated a cDNA for a novel human amiloride-sensitive Na channel isoform (called ) which is expressed mainly in brain, pancreas, testis, and ovary…”
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The Acid-sensitive Ionic Channel Subunit ASIC and the Mammalian Degenerin MDEG Form a Heteromultimeric H+-gated Na+ Channel with Novel Properties by Bassilana, Frédéric, Champigny, Guy, Waldmann, Rainer, de Weille, Jan R., Heurteaux, Catherine, Lazdunski, Michel

“…Proton-gated cation channels are acid sensors that are present in both sensory neurons and in neurons of the central nervous system. One of these acid-sensing…”
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Cloning and functional expression of a novel degenerin-like Na+ channel gene in mammals by Sakai, Hideki, Lingueglia, Eric, Champigny, Guy, Mattei, Marie‐Geneviève, Lazdunski, Michel

“…A degenerate polymerase chain reaction (PCR) homology screening procedure was applied to rat brain cDNA in order to identify novel genes belonging to the…”
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Functional Degenerin-containing Chimeras Identify Residues Essential for Amiloride-sensitive Na- Channel Function by Waldmann, Rainer, Champigny, Guy, Lazdunski, Michel

“…The highly selective, amiloride-sensitive Na- channel is formed of three homologous subunits termed α, β, and γ. The three subunits exhibit similarities with…”
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Mutations Causing Neurodegeneration in Caenorhabditis elegans Drastically Alter the pH Sensitivity and Inactivation of the Mammalian H+-gated Na+ Channel MDEG1 by Champigny, G, Voilley, N, Waldmann, R, Lazdunski, M

“…The mammalian degenerin MDEG1 belongs to the nematode degenerin/epithelial Na + channel superfamily. It is constitutively activated by the same mutations that…”
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dGNaC1, a gonad-specific amiloride-sensitive Na+ channel by Darboux, I, Lingueglia, E, Champigny, G, Coscoy, S, Barbry, P, Lazdunski, M

“…Amiloride-sensitive sodium channels have been implicated in reproductive and early developmental processes of several species. These include the fast block of…”
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H+-Gated Cation Channelsa by WALDMANN, RAINER, CHAMPIGNY, GUY, LINGUEGLIA, ERIC, DE WEILLE, JAN R., HEURTEAUX, C., LAZDUNSKI, MICHEL

“…H+‐gated cation channels are members of a new family of ionic channels, which includes the epithelial Na+ channel and the FMRFamide‐activated Na+ channel…”
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H(+)-gated cation channels by Waldmann, R, Champigny, G, Lingueglia, E, De Weille, J R, Heurteaux, C, Lazdunski, M

“…H(+)-gated cation channels are members of a new family of ionic channels, which includes the epithelial Na+ channel and the FMRFamide-activated Na+ channel…”
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Altered chloride ion channel kinetics associated with the ΔF508 cystic fibrosis mutation by Dalemans, Wilfried, Barbry, Pascal, Champigny, Guy, Jallat, Sophie, Jallat, Sophie, Dott, Karin, Dreyer, Dominique, Crystal, Ronald G, Pavirani, Andréa, Lecocq, Jean-Pierre, Lazdunski, Michel

“…Cystic fibrosis is associated with a defect in epithelial chloride ion transport which is caused by mutations in a membrane protein called CFTR (cystic…”
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The Lung Amiloride-Sensitive Na+Channel: Biophysical Properties, Pharmacology, Ontogenesis, and Molecular Cloning by Voilley, Nicolas, Lingueglia, Eric, Champigny, Guy, Mattei, Marie-Genevieve, Waldmann, Rainer, Lazdunski, Michel, Barbry, Pascal

“…Water balance in the lung is controlled via active Na+and Cl-transport. Electrophysiological measurements on lung epithelial cells demonstrated the presence of…”
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Genotype–phenotype analysis of a newly discovered family with Liddleʼs syndrome by Jeunemaitre, Xavier, Bassilana, Frédéric, Persu, Alexandre, Dumont, Cécile, Champigny, Guy, Lazdunski, Michel, Corvol, Pierre, Barbry, Pascal

“…OBJECTIVETo investigate the clinical, biologic, and molecular abnormalities in a family with Liddleʼs syndrome and analyze the short- and long-term efficacies…”
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Different homologous subunits of the amiloride-sensitive Na+ channel are differently regulated by aldosterone by LINGUEGLIA, E, RENARD, S, WALDMANN, R, VOILLEY, N, CHAMPIGNY, G, PLASS, H, LAZDUNSKI, M, BARBRY, P

“…Long term regulation of the amiloride-sensitive Na+ channel activity by steroid hormones occurs via de novo protein synthesis. The messenger level of RCNaCh1,…”
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Zn 2+ and H + Are Coactivators of Acid-sensing Ion Channels by Baron, Anne, Schaefer, Lionel, Lingueglia, Eric, Champigny, Guy, Lazdunski, Michel

“…Acid-sensing ion channels (ASICs) are cationic channels activated by extracellular protons. They are expressed in sensory neurons, where they are thought to be…”
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Regulation of expression of the lung amiloride‐sensitive Na+ channel by steroid hormones by Champigny, G., Voilley, N., Lingueglia, E., Friend, V., Barbry, P., Lazdunski, M.

“…Molecular cloning of the amiloride‐sensitive Na+ channel has permitted analysis of the mechanisms of its stimulation by steroids. In rat lung cells in primary…”
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