Search Results - "Chamow, Steven M."

Influence of histidine on the stability and physical properties of a fully human antibody in aqueous and solid forms by BEI CHEN, BAUTISTA, Raquel, YU, Kwok, ZAPATA, Gerardo A, MULKERRIN, Michael G, CHAMOW, Steven M

“…The aim of the study was to investigate the effect of histidine on the stability and physical properties of a fully human anti-IL8 monoclonal antibody…”
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Generation of recombinant hyperimmune globulins from diverse B-cell repertoires by Keating, Sheila M., Mizrahi, Rena A., Adams, Matthew S., Asensio, Michael A., Benzie, Emily, Carter, Kyle P., Chiang, Yao, Edgar, Robert C., Gautam, Bishal K., Gras, Ashley, Leong, Jackson, Leong, Renee, Lim, Yoong Wearn, Manickam, Vishal A., Medina-Cucurella, Angelica V., Niedecken, Ariel R., Saini, Jasmeen, Simons, Jan Fredrik, Spindler, Matthew J., Stadtmiller, Kacy, Tinsley, Brendan, Wagner, Ellen K., Wayham, Nicholas, Tracy, LaRee, Lundberg, Carina Vingsbo, Büscher, Dirk, Terencio, Jose Vicente, Roalfe, Lucy, Pearce, Emma, Richardson, Hayley, Goldblatt, David, Ramjag, Anushka T., Carrington, Christine V. F., Simmons, Graham, Muench, Marcus O., Chamow, Steven M., Monroe, Bryan, Olson, Charles, Oguin, Thomas H., Lynch, Heather, Jeanfreau, Robert, Mosher, Rachel A., Walch, Matthew J., Bartley, Christopher R., Ross, Carl A., Meyer, Everett H., Adler, Adam S., Johnson, David S.

“…Plasma-derived polyclonal antibody therapeutics, such as intravenous immunoglobulin, have multiple drawbacks, including low potency, impurities, insufficient…”
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NMR structure of human thymosin alpha-1 by Elizondo-Riojas, Miguel-Angel, Chamow, Steven M., Tuthill, Cynthia W., Gorenstein, David G., Volk, David E.

“…► Structure of human thymosin alpha in 40% TFE/60% water using an 800MHz NMR magnet. ► Greatly improved chemical shifts and structure compared to literature. ►…”
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Therapeutic antibody expression technology by Chadd, Helen E, Chamow, Steven M

“…With the technological advances made during the past decade, antibodies now represent an important and growing class of biotherapeutics. With the potential new…”
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GMP Manufacturing and IND-Enabling Studies of a Recombinant Hyperimmune Globulin Targeting SARS-CoV-2 by Mizrahi, Rena A, Lin, Wendy Y, Gras, Ashley, Niedecken, Ariel R, Wagner, Ellen K, Keating, Sheila M, Ikon, Nikita, Manickam, Vishal A, Asensio, Michael A, Leong, Jackson, Medina-Cucurella, Angelica V, Benzie, Emily, Carter, Kyle P, Chiang, Yao, Edgar, Robert C, Leong, Renee, Lim, Yoong Wearn, Simons, Jan Fredrik, Spindler, Matthew J, Stadtmiller, Kacy, Wayham, Nicholas, Büscher, Dirk, Terencio, Jose Vicente, Germanio, Clara Di, Chamow, Steven M, Olson, Charles, Pino, Paula A, Park, Jun-Gyu, Hicks, Amberlee, Ye, Chengjin, Garcia-Vilanova, Andreu, Martinez-Sobrido, Luis, Torrelles, Jordi B, Johnson, David S, Adler, Adam S

“…Conventionally, hyperimmune globulin drugs manufactured from pooled immunoglobulins from vaccinated or convalescent donors have been used in treating…”
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Glycoengineering of Therapeutic Glycoproteins:  In Vitro Galactosylation and Sialylation of Glycoproteins with Terminal N-Acetylglucosamine and Galactose Residues by Raju, T. Shantha, Briggs, John B, Chamow, Steven M, Winkler, Marjorie E, Jones, Andrew J. S

“…Therapeutic glycoproteins produced in different host cells by recombinant DNA technology often contain terminal GlcNAc and Gal residues. Such glycoproteins…”
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Designing CD4 immunoadhesins for AIDS therapy by Capon, Daniel J, Chamow, Steven M, Mordenti, Joyce, Marsters, Scot A, Gregory, Timothy, Mitsuya, Hiroaki, Byrn, Randal A, Lucas, Catherine, Wurm, Florian M, Groopman, Jerome E, Broder, Samuel, Smith, Douglas H

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A p55 TNF Receptor Immunoadhesin Prevents T Cell-Mediated Intestinal Injury by Inhibiting Matrix Metalloproteinase Production by Pender, Sylvia L. F, Fell, John M. E, Chamow, Steven M, Ashkenazi, Avi, MacDonald, Thomas T

“…Anti-TNF-alpha Ab therapy has been shown to be of benefit in the treatment of active Crohn's disease, but the tissue-injuring processes in the gut mediated by…”
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Biological properties of a CD4 immunoadhesin by Byrn, Randal A, Mordenti, Joyce, Lucas, Catherine, Smith, Douglas, Marsters, Scot A, Johnson, Jennifer S, Cossum, Paul, Chamow, Steven M, Wurm, Florian M, Gregory, Timothy, Groopman, Jerome E, Capon, Daniel J

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Sulfated Oligosaccharides Promote Hepatocyte Growth Factor Association and Govern Its Mitogenic Activity by Zioncheck, Thomas F., Richardson, Louise, Liu, Jun, Chang, Ling, King, Kathleen L., Bennett, Gregory L., Fügedi, Pèter, Chamow, Steven M., Schwall, Ralph H., Stack, Robert J.

“…Hepatocyte growth factor (HGF) is a potent mitogen, motogen, and morphogen for various epithelial cell types. The pleiotropic effects of HGF are mediated by…”
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Vaccination with a Synthetic Zona Pellucida Peptide Produces Long-Term Contraception in Female Mice by Millar, Sarah E., Chamow, Steven M., Baur, Anne W., Oliver, Constance, Robey, Frank, Dean, Jurrien

“…The zona pellucida surrounding mouse oocytes is an extracellular matrix composed of three sulfated glycoproteins, ZP1, ZP2, and ZP3. It has been demonstrated…”
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A simple, two-component buffer enhances use of chromatofocusing for processing of therapeutic proteins by Logan, Kathleen A., Lagerlund, Inger, Chamow, Steven M.

“…To extend the feasibility of chromatofocusing to industrial use, we have developed a simple chromatofocusing buffer system capable of generating a smooth pH…”
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Immunoadhesins as research tools and therapeutic agents by Ashkenazi, Avi, Chamow, Steven M

“…An immunoadhesin is a fusion protein that combines the target-binding region of a receptor, an adhesion molecule, a ligand, or an enzyme, with the Fc region of…”
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Enzymic cleavage of a CD4 immunoadhesin generates crystallizable, biologically active Fd-like fragments by Chamow, Steven M, Peers, David H, Byrn, Randal A, Mulkerrin, Michael G, Harris, Reed J, Wang, Wen Ching, Bjorkman, Pamela J, Capon, Daniel J, Ashkenazi, Avi

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Modification of CD4 Immunoadhesin with Monomethoxypoly(Ethylene Glycol) Aldehyde via Reductive Alkylation by Chamow, Steven M, Kogan, Timothy P, Venuti, Michael, Gadek, Thomas, Harris, Reed J, Peers, David H, Mordenti, Joyce, Shak, Steven, Ashkenazi, Avi

“…CD4 immunoadhesin (CD4-IgG) is a chimeric glycoprotein molecule comprised of the gp120-binding portion of human CD4 fused to the hinge and Fc portions of human…”
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Oocyte-Specific Expression of Mouse Zp-2: Developmental Regulation of the Zona Pellucida Genes by Liang, Li-Fang, Chamow, Steven M., Dean, Jurrien

“…The zona pellucida surrounds all mammalian oocytes and plays a vital role at fertilization and in early development. The genes that code for two of the mouse…”
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Immunoadhesins: principles and applications by Chamow, Steven M., Ashkenazi, Avi

“…The prototypic immunoadhesin is an antibody-like molecule that fuses the Fc region of an immunoglobulin and the ligand-binding region of a receptor or adhesion…”
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Immunoadhesins: An Alternative to Human Monoclonal Antibodies by Ashkenazi, Avi, Chamow, Steven M.

“…Immunoadhesins are chimeric, antibody-like molecules that combine the functional domain of a binding protein, usually a receptor, ligand, or cell-adhesion…”
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Designing CD4 immunoadhesins for AIDS therapy by Capon, D J, Chamow, S M, Mordenti, J, Marsters, S A, Gregory, T, Mitsuya, H, Byrn, R A, Lucas, C, Wurm, F M, Groopman, J E

“…A newly-constructed antibody-like molecule containing the gp120-binding domain of the receptor for human immunodeficiency virus blocks HIV-1 infection of T…”
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Protection Against Endotoxic Shock by a Tumor Necrosis Factor Receptor Immunoadhesin by Ashkenazi, Avi, Marsters, Scot A., Capon, Daniel J., Chamow, Steven M., Figari, Irene S., Pennica, Diane, Goeddel, David V., Poladino, Michael A., Smith, Douglas H.

“…Tumor necrosis factors (TNF) α and β are structurally related cytokines that mediate a wide range of immunological, inflammatory, and cytotoxic effects. During…”
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