Search Results - "Chamoun, Mira"

Microglial activation and tau propagate jointly across Braak stages by Pascoal, Tharick A., Benedet, Andrea L., Ashton, Nicholas J., Kang, Min Su, Therriault, Joseph, Chamoun, Mira, Savard, Melissa, Lussier, Firoza Z., Tissot, Cécile, Karikari, Thomas K., Ottoy, Julie, Mathotaarachchi, Sulantha, Stevenson, Jenna, Massarweh, Gassan, Schöll, Michael, de Leon, Mony J., Soucy, Jean-Paul, Edison, Paul, Blennow, Kaj, Zetterberg, Henrik, Gauthier, Serge, Rosa-Neto, Pedro

“…Compelling experimental evidence suggests that microglial activation is involved in the spread of tau tangles over the neocortex in Alzheimer’s disease (AD)…”
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Aβ-induced vulnerability propagates via the brain’s default mode network by Pascoal, Tharick A., Mathotaarachchi, Sulantha, Kang, Min Su, Mohaddes, Sara, Shin, Monica, Park, Ah Yeon, Parent, Maxime J., Benedet, Andrea L., Chamoun, Mira, Therriault, Joseph, Hwang, Heungsun, Cuello, A. Claudio, Misic, Bratislav, Soucy, Jean-Paul, Aston, John A. D., Gauthier, Serge, Rosa-Neto, Pedro

“…The link between brain amyloid-β (Aβ), metabolism, and dementia symptoms remains a pressing question in Alzheimer’s disease. Here, using positron emission…”
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Association of locus coeruleus integrity with Braak stage and neuropsychiatric symptom severity in Alzheimer's disease by Cassidy, Clifford M, Therriault, Joseph, Pascoal, Tharick A, Cheung, Victoria, Savard, Melissa, Tuominen, Lauri, Chamoun, Mira, McCall, Adelina, Celebi, Seyda, Lussier, Firoza, Massarweh, Gassan, Soucy, Jean-Paul, Weinshenker, David, Tardif, Christine, Ismail, Zahinoor, Gauthier, Serge, Rosa-Neto, Pedro

“…The clinical and pathophysiological correlates of locus coeruleus (LC) degeneration in Alzheimer's disease (AD) could be clarified using a method to index LC…”
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APOEε4 potentiates the relationship between amyloid-β and tau pathologies by Therriault, Joseph, Benedet, Andrea L., Pascoal, Tharick A., Mathotaarachchi, Sulantha, Savard, Melissa, Chamoun, Mira, Thomas, Emilie, Kang, Min Su, Lussier, Firoza, Tissot, Cecile, Soucy, Jean-Paul, Massarweh, Gassan, Rej, Soham, Saha-Chaudhuri, Paramita, Poirier, Judes, Gauthier, Serge, Rosa-Neto, Pedro

“…APOEε4 is the most well-established genetic risk factor for sporadic Alzheimer’s disease and is associated with cerebral amyloid-β. However, the association…”
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Amyloid-beta modulates the association between neurofilament light chain and brain atrophy in Alzheimer’s disease by Kang, Min Su, Aliaga, Arturo Aliaga, Shin, Monica, Mathotaarachchi, Sulantha, Benedet, Andrea L., Pascoal, Tharick A., Therriault, Joseph, Chamoun, Mira, Savard, Melissa, Devenyi, Gabriel A., Mathieu, Axel, Chakravarty, M. Mallar, Sandelius, Åsa, Blennow, Kaj, Zetterberg, Henrik, Soucy, Jean-Paul, Cuello, A. Claudio, Massarweh, Gassan, Gauthier, Serge, Rosa-Neto, Pedro

“…Neurofilament light chain (NFL) measurement has been gaining strong support as a clinically useful neuronal injury biomarker for various neurodegenerative…”
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Longitudinal 18F-MK-6240 tau tangles accumulation follows Braak stages by Pascoal, Tharick A, Benedet, Andrea L, Tudorascu, Dana L, Therriault, Joseph, Mathotaarachchi, Sulantha, Savard, Melissa, Lussier, Firoza Z, Tissot, Cécile, Chamoun, Mira, Kang, Min Su, Stevenson, Jenna, Massarweh, Gassan, Guiot, Marie-Christine, Soucy, Jean-Paul, Gauthier, Serge, Rosa-Neto, Pedro

“…Tracking longitudinal tau tangles accumulation across the Alzheimer's disease continuum is crucial to better understand the natural history of tau pathology…”
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In vivo quantification of neurofibrillary tangles with [ 18 F]MK-6240 by Pascoal, Tharick A, Shin, Monica, Kang, Min Su, Chamoun, Mira, Chartrand, Daniel, Mathotaarachchi, Sulantha, Bennacef, Idriss, Therriault, Joseph, Ng, Kok Pin, Hopewell, Robert, Bouhachi, Reda, Hsiao, Hung-Hsin, Benedet, Andrea L, Soucy, Jean-Paul, Massarweh, Gassan, Gauthier, Serge, Rosa-Neto, Pedro

“…Imaging agents capable of quantifying the brain's tau aggregates will allow a more precise staging of Alzheimer's disease (AD). The aim of the present study…”
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Cerebrospinal fluid p-tau231 as an early indicator of emerging pathology in Alzheimer's disease by Ashton, Nicholas J., Benedet, Andréa L., Pascoal, Tharick A., Karikari, Thomas K., Lantero-Rodriguez, Juan, Brum, Wagner S., Mathotaarachchi, Sulantha, Therriault, Joseph, Savard, Melissa, Chamoun, Mira, Stoops, Erik, Francois, Cindy, Vanmechelen, Eugeen, Gauthier, Serge, Zimmer, Eduardo R., Zetterberg, Henrik, Blennow, Kaj, Rosa-Neto, Pedro

“…Phosphorylated tau (p-tau) epitopes in cerebrospinal fluid (CSF) are accurate biomarkers for a pathological and clinical diagnosis of Alzheimer's disease (AD)…”
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Biomarker modeling of Alzheimer's disease using PET-based Braak staging by Therriault, Joseph, Pascoal, Tharick A, Lussier, Firoza Z, Tissot, Cécile, Chamoun, Mira, Bezgin, Gleb, Servaes, Stijn, Benedet, Andrea L, Ashton, Nicholas J, Karikari, Thomas K, Lantero-Rodriguez, Juan, Kunach, Peter, Wang, Yi-Ting, Fernandez-Arias, Jaime, Massarweh, Gassan, Vitali, Paolo, Soucy, Jean-Paul, Saha-Chaudhuri, Paramita, Blennow, Kaj, Zetterberg, Henrik, Gauthier, Serge, Rosa-Neto, Pedro

“…Gold-standard diagnosis of Alzheimer's disease (AD) relies on histopathological staging systems. Using the topographical information from [ F]MK6240 tau…”
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[11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease by Pascoal, Tharick A., Chamoun, Mira, Lax, Elad, Wey, Hsiao-Ying, Shin, Monica, Ng, Kok Pin, Kang, Min Su, Mathotaarachchi, Sulantha, Benedet, Andrea L., Therriault, Joseph, Lussier, Firoza Z., Schroeder, Frederick A., DuBois, Jonathan M., Hightower, Baileigh G., Gilbert, Tonya M., Zürcher, Nicole R., Wang, Changning, Hopewell, Robert, Chakravarty, Mallar, Savard, Melissa, Thomas, Emilie, Mohaddes, Sara, Farzin, Sarah, Salaciak, Alyssa, Tullo, Stephanie, Cuello, A. Claudio, Soucy, Jean-Paul, Massarweh, Gassan, Hwang, Heungsun, Kobayashi, Eliane, Hyman, Bradley T., Dickerson, Bradford C., Guiot, Marie-Christine, Szyf, Moshe, Gauthier, Serge, Hooker, Jacob M., Rosa-Neto, Pedro

“…Alzheimer’s disease (AD) is characterized by the brain accumulation of amyloid-β and tau proteins. A growing body of literature suggests that epigenetic…”
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Cholinergic Potentiation Alters Perceptual Eye Dominance Plasticity Induced by a Few Hours of Monocular Patching in Adults by Sheynin, Yasha, Chamoun, Mira, Baldwin, Alex S, Rosa-Neto, Pedro, Hess, Robert F, Vaucher, Elvire

“…A few hours of monocular deprivation with a diffuser eye patch temporarily strengthens the contribution of the deprived eye to binocular vision. This shift in…”
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Comparing tau status determined via plasma pTau181, pTau231 and [18F]MK6240 tau-PET by Tissot, Cécile, Therriault, Joseph, Kunach, Peter, L Benedet, Andréa, Pascoal, Tharick A., Ashton, Nicholas J., Karikari, Thomas K., Servaes, Stijn, Lussier, Firoza Z., Chamoun, Mira, Tudorascu, Dana L., Stevenson, Jenna, Rahmouni, Nesrine, Poltronetti, Nina Margherita, Pallen, Vanessa, Bezgin, Gleb, Kang, Min Su, Mathotaarachchi, Sulantha S., Wang, Yi-Ting, Fernandez Arias, Jaime, Ferreira, Pamela Cristina Lukasewicz, Ferrari-Souza, João Pedro, Vanmechelen, Eugeen, Blennow, Kaj, Zetterberg, Henrik, Gauthier, Serge, Rosa-Neto, Pedro

“…Tau in Alzheimer's disease (AD) is assessed via cerebrospinal fluid (CSF) and Positron emission tomography (PET). Novel methods to detect phosphorylated tau…”
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Plasma pTau181 predicts cortical brain atrophy in aging and Alzheimer's disease by Tissot, Cécile, L Benedet, Andréa, Therriault, Joseph, Pascoal, Tharick A, Lussier, Firoza Z, Saha-Chaudhuri, Paramita, Chamoun, Mira, Savard, Melissa, Mathotaarachchi, Sulantha S, Bezgin, Gleb, Wang, Yi-Ting, Fernandez Arias, Jaime, Rodriguez, Juan Lantero, Snellman, Anniina, Ashton, Nicholas J, Karikari, Thomas K, Blennow, Kaj, Zetterberg, Henrik, De Villers-Sidani, Etienne, Huot, Philippe, Gauthier, Serge, Rosa-Neto, Pedro

“…To investigate the association of plasma pTau181, assessed with a new immunoassay, with neurodegeneration of white matter and gray matter cross-sectionally and…”
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Publisher Correction: Microglial activation and tau propagate jointly across Braak stages by Pascoal, Tharick A., Benedet, Andrea L., Ashton, Nicholas J., Kang, Min Su, Therriault, Joseph, Chamoun, Mira, Savard, Melissa, Lussier, Firoza Z., Tissot, Cécile, Karikari, Thomas K., Ottoy, Julie, Mathotaarachchi, Sulantha, Stevenson, Jenna, Massarweh, Gassan, Schöll, Michael, de Leon, Mony J., Soucy, Jean-Paul, Edison, Paul, Blennow, Kaj, Zetterberg, Henrik, Gauthier, Serge, Rosa-Neto, Pedro

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Author Correction: [11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease by Pascoal, Tharick A., Chamoun, Mira, Lax, Elad, Wey, Hsiao-Ying, Shin, Monica, Ng, Kok Pin, Kang, Min Su, Mathotaarachchi, Sulantha, Benedet, Andrea L., Therriault, Joseph, Lussier, Firoza Z., Schroeder, Frederick A., DuBois, Jonathan M., Hightower, Baileigh G., Gilbert, Tonya M., Zürcher, Nicole R., Wang, Changning, Hopewell, Robert, Chakravarty, Mallar, Savard, Melissa, Thomas, Emilie, Mohaddes, Sara, Farzin, Sarah, Salaciak, Alyssa, Tullo, Stephanie, Cuello, A. Claudio, Soucy, Jean-Paul, Massarweh, Gassan, Hwang, Heungsun, Kobayashi, Eliane, Hyman, Bradley T., Dickerson, Bradford C., Guiot, Marie-Christine, Szyf, Moshe, Gauthier, Serge, Hooker, Jacob M., Rosa-Neto, Pedro

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Plasma neurofilament light associates with Alzheimer's disease metabolic decline in amyloid-positive individuals by Benedet, Andréa L., Ashton, Nicholas J., Pascoal, Tharick A., Leuzy, Antoine, Mathotaarachchi, Sulantha, Kang, Min S., Therriault, Joseph, Savard, Melissa, Chamoun, Mira, Schöll, Michael, Zimmer, Eduardo R., Gauthier, Serge, Labbe, Aurélie, Zetterberg, Henrik, Blennow, Kaj, Neto, Pedro R.

“…Neurofilament light chain (NfL) is a promising blood biomarker to detect neurodegeneration in Alzheimer's disease (AD) and other brain disorders. However,…”
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18F-MK-6240 PET for early and late detection of neurofibrillary tangles by Pascoal, Tharick A, Therriault, Joseph, Benedet, Andrea L, Savard, Melissa, Lussier, Firoza Z, Chamoun, Mira, Tissot, Cécile, Qureshi, Muhammad Naveed Iqbal, Kang, Min Su, Mathotaarachchi, Sulantha, Stevenson, Jenna, Hopewell, Robert, Massarweh, Gassan, Soucy, Jean-Paul, Gauthier, Serge, Rosa-Neto, Pedro

“…Braak stages of tau neurofibrillary tangle accumulation have been incorporated in the criteria for the neuropathological diagnosis of Alzheimer's disease. It…”
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CSF tau368/total-tau ratio reflects cognitive performance and neocortical tau better compared to p-tau181 and p-tau217 in cognitively impaired individuals by Simrén, Joel, Brum, Wagner S, Ashton, Nicholas J, Benedet, Andrea L, Karikari, Thomas K, Kvartsberg, Hlin, Sjons, Emma, Lussier, Firoza Z, Chamoun, Mira, Stevenson, Jenna, Hopewell, Robert, Pallen, Vanessa, Ye, Keqiang, Pascoal, Tharick A, Zetterberg, Henrik, Rosa-Neto, Pedro, Blennow, Kaj

“…Cerebrospinal fluid (CSF) tau biomarkers are reliable diagnostic markers for Alzheimer's disease (AD). However, their strong association with amyloid pathology…”
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Quantification of SNAP-25 with mass spectrometry and Simoa: a method comparison in Alzheimer's disease by Nilsson, Johanna, Ashton, Nicholas J, Benedet, Andrea L, Montoliu-Gaya, Laia, Gobom, Johan, Pascoal, Tharick A, Chamoun, Mira, Portelius, Erik, Jeromin, Andreas, Mendes, Muriel, Zetterberg, Henrik, Rosa-Neto, Pedro, Brinkmalm, Ann, Blennow, Kaj

“…Synaptic dysfunction and degeneration are central to Alzheimer's disease (AD) and have been found to correlate strongly with cognitive decline. Thus, studying…”
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Association between regional tau pathology and neuropsychiatric symptoms in aging and dementia due to Alzheimer's disease by Tissot, Cécile, Therriault, Joseph, Pascoal, Tharick A., Chamoun, Mira, Lussier, Firoza Z., Savard, Melissa, Mathotaarachchi, Sulantha S., L. Benedet, Andréa, Thomas, Emilie M., Parsons, Marlee, Nasreddine, Ziad, Rosa‐Neto, Pedro, Gauthier, Serge

“…Background Neuropsychiatric symptoms (NPS) are frequent in aging and Alzheimer's disease (AD). Here we study the relationship between NPS and AD pathologies in…”
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