Search Results - "Chamkha, Imen"
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Cell-permeable succinate prodrugs rescue mitochondrial respiration in cellular models of acute acetaminophen overdose
Published in PloS one (06-04-2020)“…Acetaminophen is one of the most common over-the-counter pain medications used worldwide and is considered safe at therapeutic dose. However, intentional and…”
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Cell-Permeable Succinate Rescues Mitochondrial Respiration in Cellular Models of Statin Toxicity
Published in International journal of molecular sciences (01-01-2021)“…Statins are the cornerstone of lipid-lowering therapy. Although generally well tolerated, statin-associated muscle symptoms (SAMS) represent the main reason…”
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3
Human papillomavirus-associated head and neck squamous cell carcinoma cells rely on glycolysis and display reduced oxidative phosphorylation
Published in Frontiers in oncology (2023)“…Head and neck squamous cell carcinoma (HNSCC) constitutes a heterogeneous group of cancers. Human papilloma virus (HPV) is associated with a subtype of HNSCC…”
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Cell-Permeable Succinate Rescues Mitochondrial Respiration in Cellular Models of Amiodarone Toxicity
Published in International journal of molecular sciences (01-11-2021)“…Amiodarone is a potent antiarrhythmic drug and displays substantial liver toxicity in humans. It has previously been demonstrated that amiodarone and its…”
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The relationship between mitochondrial respiration, resting metabolic rate and blood cell count in great tits
Published in Biology open (01-03-2024)“…Although mitochondrial respiration is believed to explain a substantial part of the variation in resting metabolic rate (RMR), few studies have empirically…”
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Correlation of mitochondrial respiration in platelets, peripheral blood mononuclear cells and muscle fibers
Published in Heliyon (15-03-2024)“…There is a growing interest for the possibility of using peripheral blood cells (including platelets) as markers for mitochondrial function in less accessible…”
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Bioenergetic bypass using cell-permeable succinate, but not methylene blue, attenuates metformin-induced lactate production
Published in Intensive care medicine experimental (01-08-2018)“…Background Metformin is the most common pharmacological treatment for type 2 diabetes. It is considered safe but has been associated with the development of…”
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8
A whole blood approach improves speed and accuracy when measuring mitochondrial respiration in intact avian blood cells
Published in The FASEB journal (01-03-2023)“…Understanding mitochondrial biology and pathology is key to understanding the evolution of animal form and function. However, mitochondrial measurement often…”
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Plasticity of mitochondrial function safeguards phosphorylating respiration during in vitro simulation of rest‐phase hypothermia
Published in The FASEB journal (01-04-2023)“…Many animals downregulate body temperature to save energy when resting (rest‐phase hypothermia). Small birds that winter at high latitudes have comparatively…”
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Co segregation of the m.1555A>G mutation in the MT-RNR1 gene and mutations in MT-ATP6 gene in a family with dilated mitochondrial cardiomyopathy and hearing loss: A whole mitochondrial genome screening
Published in Biochemical and biophysical research communications (26-02-2017)“…Mitochondrial disease refers to a heterogeneous group of disorders resulting in defective cellular energy production due to dysfunction of the mitochondrial…”
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11
Mitochondrial DNA triplication and punctual mutations in patients with mitochondrial neuromuscular disorders
Published in Biochemical and biophysical research communications (29-04-2016)“…Mitochondrial diseases are a heterogeneous group of disorders caused by the impairment of the mitochondrial oxidative phosphorylation system which have been…”
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12
Co segregation of the m.1555A>G mutation in the MT-RNR1 gene and mutations in MT-ATP6 gene in a family with dilated mitochondrial cardiomyopathy and hearing loss : A whole mitochondrial genome screening
Published in Biochemical and biophysical research communications (26-02-2017)“…Mitochondrial disease refers to a heterogeneous group of disorders resulting in defective cellular energy production due to dysfunction of the mitochondrial…”
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13
Do GSTM1 and GSTT1 polymorphisms influence the risk of developing mitochondrial diseases in a Tunisian population?
Published in Environmental science and pollution research international (01-02-2018)“…Mitochondria play an essential role to supply the cell with metabolic energy in the form of adenosine triphosphate (ATP) through oxidative phosphorylation…”
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A novel MT-CO1 m.6498C>A variation associated with the m.7444G>A mutation in the mitochondrial COI/tRNA(Ser(UCN)) genes in a patient with hearing impairment, diabetes and congenital visual loss
Published in Biochemical and biophysical research communications (11-01-2013)“…Mitochondrial diseases are a clinically heterogeneous group of disorders that arise as a result of dysfunction of the mitochondrial respiratory chain…”
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A novel m.12908T>A mutation in the mitochondrial ND5 gene in patient with infantile-onset Pompe disease
Published in Biochemical and biophysical research communications (07-12-2012)“…► A newborn boy with clinical features of Pompe disease was studied. ► A whole mitochondrial mutational analysis was performed. ► A novel mutation m.12908T>A…”
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Molecular-Clinical Correlation in a Family With a Novel Heteroplasmic Leigh Syndrome Missense Mutation in the Mitochondrial Cytochrome c Oxidase III Gene
Published in Journal of child neurology (01-01-2011)“…Cytochrome c oxidase is an essential component of the mitochondrial respiratory chain that catalyzes the reduction of molecular oxygen by reduced cytochrome c…”
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A novel MT-CO1 m.6498C>A variation associated with the m.7444G>A mutation in the mitochondrial COI/tRNASer(UCN) genes in a patient with hearing impairment, diabetes and congenital visual loss
Published in Biochemical and biophysical research communications (11-01-2013)“…► A patient with hearing impairment, maternally inherited diabetes and congenital visual loss was described. ► A whole mitochondrial mutational analysis was…”
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A novel m.3395A>G missense mutation in the mitochondrial ND1 gene associated with the new tRNAIle m.4316A>G mutation in a patient with hypertrophic cardiomyopathy and profound hearing loss
Published in Biochemical and biophysical research communications (07-01-2011)“…► We report 2 novel mitochondrial mutations a patient with hypertrophic cardiomyopathy and hearing loss. ► The m.3395A>G (Y30C, ND1) mutation is located in an…”
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Whole mitochondrial genome analysis in two families with dilated mitochondrial cardiomyopathy: detection of mutations in MT-ND2 and MT-TL1 genes
Published in Mitochondrial DNA. Part A. DNA mapping, sequencing, and analysis (03-07-2016)“…Pathogenic mitochondrial DNA (mtDNA) mutations leading to mitochondrial dysfunction can cause cardiomyopathy and heart failure. These mutations were described…”
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A novel m.3395A>G missense mutation in the mitochondrial ND1 gene associated with the new tRNA(Ile) m.4316A>G mutation in a patient with hypertrophic cardiomyopathy and profound hearing loss
Published in Biochemical and biophysical research communications (07-01-2011)“…Mitochondria are essential for early cardiac development and impaired regulation of mitochondrial function was implicated in congenital heart diseases. We…”
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