Search Results - "Chamessian, Alexander"

Pain regulation by non-neuronal cells and inflammation by Ji, Ru-Rong, Chamessian, Alexander, Zhang, Yu-Qiu

“…Acute pain is protective and a cardinal feature of inflammation. Chronic pain after arthritis, nerve injury, cancer, and chemotherapy is associated with…”
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Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors by Tavares-Ferreira, Diana, Shiers, Stephanie, Ray, Pradipta R, Wangzhou, Andi, Jeevakumar, Vivekanand, Sankaranarayanan, Ishwarya, Cervantes, Anna M, Reese, Jeffrey C, Chamessian, Alexander, Copits, Bryan A, Dougherty, Patrick M, Gereau, 4th, Robert W, Burton, Michael D, Dussor, Gregory, Price, Theodore J

“…Nociceptors are specialized sensory neurons that detect damaging or potentially damaging stimuli and are found in the dorsal root ganglia (DRG) and trigeminal…”
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Transcriptional Profiling of Somatostatin Interneurons in the Spinal Dorsal Horn by Chamessian, Alexander, Young, Michael, Qadri, Yawar, Berta, Temugin, Ji, Ru-Rong, Van de Ven, Thomas

“…The spinal dorsal horn (SDH) is comprised of distinct neuronal populations that process different somatosensory modalities. Somatostatin (SST)-expressing…”
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Transcriptional profile of spinal dynorphin-lineage interneurons in the developing mouse by Serafin, Elizabeth K., Chamessian, Alexander, Li, Jie, Zhang, Xiang, McGann, Amanda, Brewer, Chelsie L., Berta, Temugin, Baccei, Mark

“…Mounting evidence suggests that the spinal dorsal horn (SDH) contains multiple subpopulations of inhibitory interneurons that play distinct roles in…”
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Spatial, transcriptomic, and epigenomic analyses link dorsal horn neurons to chronic pain genetic predisposition by Arokiaraj, Cynthia M., Leone, Michael J., Kleyman, Michael, Chamessian, Alexander, Noh, Myung-Chul, Phan, BaDoi N., Lopes, Bettega C., Corrigan, Kelly A., Cherupally, Vijay Kiran, Yeramosu, Deepika, Franusich, Michael E., Podder, Riya, Lele, Sumitra, Shiers, Stephanie, Kang, Byungsoo, Kennedy, Meaghan M., Chen, Viola, Chen, Ziheng, Mathys, Hansruedi, Dum, Richard P., Lewis, David A., Qadri, Yawar, Price, Theodore J., Pfenning, Andreas R., Seal, Rebecca P.

“…Key mechanisms underlying chronic pain occur within the dorsal horn. Genome-wide association studies (GWASs) have identified genetic variants predisposed to…”
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5-Hydroxymethylcytosine (5hmC) and Ten-eleven translocation 1-3 (TET1-3) proteins in the dorsal root ganglia of mouse: Expression and dynamic regulation in neuropathic pain by Chamessian, Alexander G., Qadri, Yawar J., Cummins, Matthew, Hendrickson, Michele, Berta, Temugin, Buchheit, Thomas, Van de Ven, Thomas

“…Epigenetic mechanisms are increasingly implicated in chronic pain pathology. In this study, we demonstrate that the novel epigenetic mark…”
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A Biosynthetic Strategy for Re-engineering the Staphylococcus aureus Cell Wall with Non-native Small Molecules by Nelson, James W, Chamessian, Alexander G, McEnaney, Patrick J, Murelli, Ryan P, Kazmiercak, Barbara I, Spiegel, David A

“…Staphylococcus aureus (S. aureus) is a Gram-positive bacterial pathogen that has emerged as a major public health threat. Here we report that the cell wall of…”
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Correction to A Biosynthetic Strategy for Re-engineering the Staphylococcus aureus Cell Wall with Non-native Small Molecules by Nelson, James W, Chamessian, Alexander G, McEnaney, Patrick J, Murelli, Ryan P, Kazmierczak, Barbara I, Spiegel, David A

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Improving pain assessment in mice and rats with advanced videography and computational approaches by Fried, Nathan T., Chamessian, Alexander, Zylka, Mark J., Abdus-Saboor, Ishmail

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Profiling the molecular signature of satellite glial cells at the single cell level reveals high similarities between rodents and humans by Avraham, Oshri, Chamessian, Alexander, Feng, Rui, Yang, Lite, Halevi, Alexandra E., Moore, Amy M., Gereau, Robert W., Cavalli, Valeria

“…Peripheral sensory neurons located in dorsal root ganglia relay sensory information from the peripheral tissue to the brain. Satellite glial cells (SGCs) are…”
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Microglial Refinement of A-Fiber Projections in the Postnatal Spinal Cord Dorsal Horn Is Required for Normal Maturation of Dynamic Touch by Xu, Yajing, Koch, Stephanie C, Chamessian, Alexander, He, Qianru, Sundukova, Mayya, Heppenstall, Paul, Ji, RuRong, Fitzgerald, Maria, Beggs, Simon

“…Sensory systems are shaped in postnatal life by the refinement of synaptic connectivity. In the dorsal horn of the spinal cord, somatosensory circuits undergo…”
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Profiling the molecular signature of satellite glial cells at the single cell level reveals high similarities between rodents and humans by Avraham, Oshri, Chamessian, Alexander, Feng, Rui, Yang, Lite, Halevi, Alexandra E., Moore, Amy M., Gereau, Robert W., Cavalli, Valeria

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Profiling the molecular signature of satellite glial cells at the single cell level reveals high similarities between rodent and human by Avraham, Oshri, Chamessian, Alexander, Feng, Rui, Yang, Lite, Halevi, Alexandra E., Moore, Amy M., Gereau, Robert W., Cavalli, Valeria

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A new optogenetic device for spinal cord control of pain by Chamessian, Alexander, Ji, Ru-Rong

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Is Optogenetic Activation of Vglut1-Positive Aβ Low-Threshold Mechanoreceptors Sufficient to Induce Tactile Allodynia in Mice after Nerve Injury? by Chamessian, Alexander, Matsuda, Megumi, Young, Michael, Wang, Michelle, Zhang, Zhi-Jun, Liu, Di, Tobin, Brielle, Xu, Zhen-Zhong, Van de Ven, Thomas, Ji, Ru-Rong

“…Mechanical allodynia is a cardinal feature of pathological pain. Recent work has demonstrated the necessity of Aβ-low-threshold mechanoreceptors (Aβ-LTMRs) for…”
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Human cells and networks of pain: Transforming pain target identification and therapeutic development by Renthal, William, Chamessian, Alexander, Curatolo, Michele, Davidson, Steve, Burton, Michael, Dib-Hajj, Sulayman, Dougherty, Patrick M, Ebert, Allison D, Gereau, 4th, Robert W, Ghetti, Andre, Gold, Michael S, Hoben, Gwendolyn, Menichella, Daniela Maria, Mercier, Philippe, Ray, Wilson Z, Salvemini, Daniela, Seal, Rebecca P, Waxman, Stephen, Woolf, Clifford J, Stucky, Cheryl L, Price, Theodore J

“…Chronic pain is a disabling disease with limited treatment options. While animal models have revealed important aspects of pain neurobiology, therapeutic…”
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Pain Phenotypes and Associated Clinical Risk Factors Following Traumatic Amputation: Results from Veterans Integrated Pain Evaluation Research (VIPER) by Buchheit, Thomas, Van de Ven, Thomas, Hsia, Hung-Lun John, McDuffie, Mary, MacLeod, David B., White, William, Chamessian, Alexander, Keefe, Francis J., Buckenmaier, Chester “Trip”, Shaw, Andrew D.

“…Abstract Objective. To define clinical phenotypes of postamputation pain and identify markers of risk for the development of chronic pain. Design…”
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Gene Expression Profiling of Cutaneous Injured and Non-Injured Nociceptors in SNI Animal Model of Neuropathic Pain by Berta, Temugin, Perrin, Florence E., Pertin, Marie, Tonello, Raquel, Liu, Yen-Chin, Chamessian, Alexander, Kato, Ann C., Ji, Ru-Rong, Decosterd, Isabelle

“…Nociceptors are a particular subtype of dorsal root ganglion (DRG) neurons that detect noxious stimuli and elicit pain. Although recent efforts have been made…”
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Differential expression of systemic inflammatory mediators in amputees with chronic residual limb pain by Chamessian, Alexander, Van de Ven, Thomas, Buchheit, Thomas, Hsia, Hung-Lun, McDuffie, Mary, Gamazon, Eric R., Walsh, Colin, Bruehl, Stephen, Buckenmaier, Chester ‘Trip’, Shaw, Andrew

“…Chronic postsurgical pain impacts most amputees, with more than half experiencing neuralgic residual limb pain. The transition from normal acute postamputation…”
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A Role for Protease Activated Receptor Type 3 (PAR3) in Nociception Demonstrated Through Development of a Novel Peptide Agonist by Mwirigi, Juliet, Kume, Moeno, Hassler, Shayne N, Ahmad, Ayesha, Ray, Pradipta R, Jiang, Changyu, Chamessian, Alexander, Mseeh, Nakleh, Ludwig, Breya P, Rivera, Benjamin D, Nieman, Marvin T, Van de Ven, Thomas, Ji, Ru-Rong, Dussor, Gregory, Boitano, Scott, Vagner, Josef, Price, Theodore J

“…The protease activated receptor (PAR) family is a group of G-protein coupled receptors (GPCRs) activated by proteolytic cleavage of the extracellular domain…”
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