Search Results - "Chambwe, Nyasha"

Ten simple rules for creating a global network in computational biology by Adams, Jenea Imani, Ferebee, Taylor, Minto, Melyssa, Pennerman, Kayla K, Chambwe, Nyasha

“…[...]research that affects Black communities is implicitly devalued within the academic ecosystem. [...]we created the Black Women in Computational Biology…”
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A cervical cancer biorepository for pharmacogenomics research in Zimbabwe by Kuguyo, Oppah, Chambwe, Nyasha, Nhachi, Charles F B, Tsikai, Nomsa, Dandara, Collet, Matimba, Alice

“…Research infrastructures such as biorepositories are essential to facilitate genomics and its growing applications in health research and translational…”
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DNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID by Dominguez, Pilar M., Teater, Matt, Chambwe, Nyasha, Kormaksson, Matthias, Redmond, David, Ishii, Jennifer, Vuong, Bao, Chaudhuri, Jayanta, Melnick, Ari, Vasanthakumar, Aparna, Godley, Lucy A., Papavasiliou, F. Nina, Elemento, Olivier, Shaknovich, Rita

“…Changes in DNA methylation are required for the formation of germinal centers (GCs), but the mechanisms of such changes are poorly understood…”
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Compression of structured high-throughput sequencing data by Campagne, Fabien, Dorff, Kevin C, Chambwe, Nyasha, Robinson, James T, Mesirov, Jill P

“…Large biological datasets are being produced at a rapid pace and create substantial storage challenges, particularly in the domain of high-throughput…”
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SL-Cloud: A Cloud-based resource to support synthetic lethal interaction discovery [version 2; peer review: 2 approved] by Tercan, Bahar, Qin, Guangrong, Kim, Taek-Kyun, Aguilar, Boris, Phan, John, Longabaugh, William, Pot, David, Kemp, Christopher J., Chambwe, Nyasha, Shmulevich, Ilya

“…Synthetic lethal interactions (SLIs), genetic interactions in which the simultaneous inactivation of two genes leads to a lethal phenotype, are promising…”
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GobyWeb: simplified management and analysis of gene expression and DNA methylation sequencing data by Dorff, Kevin C, Chambwe, Nyasha, Zeno, Zachary, Simi, Manuele, Shaknovich, Rita, Campagne, Fabien

“…We present GobyWeb, a web-based system that facilitates the management and analysis of high-throughput sequencing (HTS) projects. The software provides…”
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SL-Cloud: A Cloud-based resource to support synthetic lethal interaction discovery [version 1; peer review: 1 approved, 1 approved with reservations] by Tercan, Bahar, Qin, Guangrong, Kim, Taek-Kyun, Aguilar, Boris, Phan, John, Longabaugh, William, Pot, David, Kemp, Christopher J., Chambwe, Nyasha, Shmulevich, Ilya

“…Synthetic lethal interactions (SLIs), genetic interactions in which the simultaneous inactivation of two genes leads to a lethal phenotype, are promising…”
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Integrative modeling identifies genetic ancestry-associated molecular correlates in human cancer by Robertson, A. Gordon, Yau, Christina, Carrot-Zhang, Jian, Damrauer, Jeffrey S., Knijnenburg, Theo A., Chambwe, Nyasha, Hoadley, Katherine A., Kemal, Anab, Zenklusen, Jean C., Cherniack, Andrew D., Beroukhim, Rameen, Zhou, Wanding

“…Cellular and molecular aberrations contribute to the disparity of human cancer incidence and etiology between ancestry groups. Multiomics profiling in The…”
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Analysis of germline-driven ancestry-associated gene expression in cancers by Chambwe, Nyasha, Sayaman, Rosalyn W., Hu, Donglei, Huntsman, Scott, Carrot-Zhang, Jian, Berger, Ashton C., Han, Seunghun, Meyerson, Matthew, Damrauer, Jeffrey S., Hoadley, Katherine A., Felau, Ina, Demchok, John A., Mensah, Michael K.A., Tarnuzzer, Roy, Wang, Zhining, Yang, Liming, Knijnenburg, Theo A., Robertson, A. Gordon, Yau, Christina, Benz, Christopher, Huang, Kuan-lin, Newberg, Justin Y., Frampton, Garrett M., Mashl, R. Jay, Ding, Li, Romanel, Alessandro, Demichelis, Francesca, Zhou, Wanding, Laird, Peter W., Shen, Hui, Wong, Christopher K., Stuart, Joshua M., Lazar, Alexander J., Le, Xiuning, Oak, Ninad, Kemal, Anab, Caesar-Johnson, Samantha, Zenklusen, Jean C., Ziv, Elad, Beroukhim, Rameen, Cherniack, Andrew D.

“…Differential mRNA expression between ancestry groups can be explained by both genetic and environmental factors. We outline a computational workflow to…”
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Analytical protocol to identify local ancestry-associated molecular features in cancer by Carrot-Zhang, Jian, Han, Seunghun, Zhou, Wanding, Damrauer, Jeffrey S., Kemal, Anab, Berger, Ashton C., Meyerson, Matthew, Hoadley, Katherine A., Felau, Ina, Caesar-Johnson, Samantha, Demchok, John A., Mensah, Michael K.A., Tarnuzzer, Roy, Wang, Zhining, Yang, Liming, Zenklusen, Jean C., Chambwe, Nyasha, Knijnenburg, Theo A., Robertson, A. Gordon, Yau, Christina, Benz, Christopher, Huang, Kuan-lin, Newberg, Justin, Frampton, Garret, Mashl, R. Jay, Ding, Li, Romanel, Alessandro, Demichelis, Francesca, Sayaman, Rosalyn W., Ziv, Elad, Laird, Peter W., Shen, Hui, Wong, Christopher K., Stuart, Joshua M., Lazar, Alexander J., Le, Xiuning, Oak, Ninad, Cherniack, Andrew D., Beroukhim, Rameen

“…People of different ancestries vary in cancer risk and outcome, and their molecular differences may indicate sources of these variations. Determining the…”
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Abstract 6115: Genetic ancestry specific meQTLs control immune function regulation in a breast cancer cohort of African and European patients by Founta, Kyriaki, Chambwe, Nyasha

“…Abstract Black women with significant African ancestry experience a disproportionately higher incidence of the most aggressive and invasive breast cancer…”
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Abstract C003: Analysis of genetic control of differential DNA methylation between breast cancer patients of African and European ancestry by Founta, Kyriaki, Chambwe, Nyasha

“…Abstract Black women with significant African ancestry experience a disproportionately higher incidence of the most aggressive and invasive breast cancer…”
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Genetic Ancestry Inference from Cancer-Derived Molecular Data across Genomic and Transcriptomic Platforms by Belleau, Pascal, Deschênes, Astrid, Chambwe, Nyasha, Tuveson, David A, Krasnitz, Alexander

“…Genetic ancestry-oriented cancer research requires the ability to perform accurate and robust genetic ancestry inference from existing cancer-derived data,…”
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Abstract C163: Interaction of germline genetic variation and environmental factors in endometrial cancer prevalence in a population biobank by Founta, Kyriaki, Qi, Yuewen, Chambwe, Nyasha

“…Abstract Despite an overall general decline in cancer mortality over the last two decades, endometrial cancer (EC) is increasing in both incidence and…”
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Active learning narrows achievement gaps for underrepresented students in undergraduate science, technology, engineering, and math by Theobald, Elli J., Hill, Mariah J., Tran, Elisa, Agrawal, Sweta, Arroyo, E. Nicole, Behling, Shawn, Chambwe, Nyasha, Cintrón, Dianne Laboy, Cooper, Jacob D., Dunster, Gideon, Grummer, Jared A., Hennessey, Kelly, Hsiao, Jennifer, Iranon, Nicole, Jones, Leonard, Jordt, Hannah, Keller, Marlowe, Lacey, Melissa E., Littlefield, Caitlin E., Lowe, Alexander, Newman, Shannon, Okolo, Vera, Olroyd, Savannah, Peecook, Brandon R., Pickett, Sarah B., Slager, David L., Caviedes-Solis, Itzue W., Stanchak, Kathryn E., Sundaravardan, Vasudha, Valdebenito, Camila, Williams, Claire R., Zinsli, Kaitlin, Freeman, Scott

“…We tested the hypothesis that underrepresented students in active-learning classrooms experience narrower achievement gaps than underrepresented students in…”
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Analysis and optimization of equitable US cancer clinical trial center access by travel time by Lee, Hassal, Bates, Alexander, Marshall, Andrea, Callier, Shawneequa, Chambwe, Nyasha, Janowitz, Tobias

“…6524 Background: Racially minoritized and socioeconomically disadvantaged populations are underrepresented in cancer clinical trials. Data-driven, quantitative…”
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Correction: Genetic Ancestry Inference from Cancer-Derived Molecular Data across Genomic and Transcriptomic Platforms by Belleau, Pascal, Deschênes, Astrid, Chambwe, Nyasha, Tuveson, David A, Krasnitz, Alexander

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Comprehensive Analysis of Genetic Ancestry and Its Molecular Correlates in Cancer by Carrot-Zhang, Jian, Chambwe, Nyasha, Damrauer, Jeffrey S., Knijnenburg, Theo A., Robertson, A. Gordon, Yau, Christina, Zhou, Wanding, Berger, Ashton C., Huang, Kuan-lin, Newberg, Justin Y., Mashl, R. Jay, Romanel, Alessandro, Sayaman, Rosalyn W., Demichelis, Francesca, Felau, Ina, Frampton, Garrett M., Han, Seunghun, Hoadley, Katherine A., Kemal, Anab, Laird, Peter W., Lazar, Alexander J., Le, Xiuning, Oak, Ninad, Shen, Hui, Wong, Christopher K., Zenklusen, Jean C., Ziv, Elad, Aguet, Francois, Ding, Li, Demchok, John A., Mensah, Michael K.A., Caesar-Johnson, Samantha, Tarnuzzer, Roy, Wang, Zhining, Yang, Liming, Alfoldi, Jessica, Karczewski, Konrad J., MacArthur, Daniel G., Meyerson, Matthew, Benz, Christopher, Stuart, Joshua M., Cherniack, Andrew D., Beroukhim, Rameen

“…We evaluated ancestry effects on mutation rates, DNA methylation, and mRNA and miRNA expression among 10,678 patients across 33 cancer types from The Cancer…”
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Abstract B030: DNA methylation profiling identifies subset of low-grade endometrial neoplasms with poor response to progestin therapy by Lin, Lawrence H., Founta, Kyriaki, Chambwe, Nyasha, DeLair, Deborah F.

“…Abstract Purpose: We aimed to investigate the DNA methylation profile of low-grade endometrial neoplasms before and after progestin therapy. Methods: This is a…”
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1227 A NOVEL CLINICAL AND BIOMARKER MODEL BASED ON TGF-B SUPERFAMILY SIGNALING PROTEINS IMPROVES ON AFP AND THE DOYLESTOWN MODEL IN PREDICTING HEPATOCELLULAR CARCINOMA ACROSS RACIAL GROUPS by Amdur, Richard L., Shetty, Kirti, Xiang, Xiyan, Crawford, James M., Latham, Patricia S., Wong, Linda L., Yu, Herbert, Tran, Chuong T., Chambwe, Nyasha, Bernstein, David, Brennan, Christina, Dima, Richard J., Satapathy, Sanjaya K., Kundra, Vikas, Grimaldi, Gregory, Mishra, Lopa

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