Search Results - "Chambers, Timothy C."

Cell Cycle-Dependent Mechanisms Underlie Vincristine-Induced Death of Primary Acute Lymphoblastic Leukemia Cells by Kothari, Anisha, Hittelman, Walter N, Chambers, Timothy C

“…Microtubule-targeting agents (MTA), such as the taxanes and vinca alkaloids, are used to treat a variety of cancers due to their ability to perturb microtubule…”
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Cyclin-Dependent Kinase 1-Mediated Bcl-xL/Bcl-2 Phosphorylation Acts as a Functional Link Coupling Mitotic Arrest and Apoptosis by Terrano, David T., Upreti, Meenakshi, Chambers, Timothy C.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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BH3 Inhibitor Sensitivity and Bcl-2 Dependence in Primary Acute Lymphoblastic Leukemia Cells by Alford, Sarah E, Kothari, Anisha, Loeff, Floris C, Eichhorn, Joshua M, Sakurikar, Nandini, Goselink, Henriette M, Saylors, Robert L, Jedema, Inge, Falkenburg, J H Frederik, Chambers, Timothy C

“…BH3 mimetic drugs may be useful to treat acute lymphoblastic leukemia (ALL) but the sensitivity of primary tumor cells has not been fully evaluated. Here,…”
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Cyclin B1 overexpression induces cell death independent of mitotic arrest by Eichhorn, Joshua M, Kothari, Anisha, Chambers, Timothy C

“…Microtubule inhibitors are widely used in cancer chemotherapy. These drugs characteristically induce mitotic arrest and cell death but the mechanisms linking…”
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Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer by Urbaniak, Alicja, Reed, Megan R., Heflin, Billie, Gaydos, John, Piña-Oviedo, Sergio, Jędrzejczyk, Marta, Klejborowska, Greta, Stępczyńska, Natalia, Chambers, Timothy C., Tackett, Alan J., Rodriguez, Analiz, Huczyński, Adam, Eoff, Robert L., MacNicol, Angus M.

“…Glioblastoma (GBM) remains the most frequently diagnosed primary malignant brain cancer in adults. Despite recent progress in understanding the biology of GBM,…”
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Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models by Urbaniak, Alicja, Reed, Megan R., Fil, Daniel, Moorjani, Anika, Heflin, Sarah, Antoszczak, Michał, Sulik, Michał, Huczyński, Adam, Kupsik, Michalina, Eoff, Robert L., MacNicol, Melanie C., Chambers, Timothy C., MacNicol, Angus M.

“…Breast cancer remains one of the leading cancers among women. Cancer stem cells (CSCs) are tumor-initiating cells which drive progression, metastasis, and…”
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Synthesis, antiproliferative activity and molecular docking of thiocolchicine urethanes by Majcher, Urszula, Urbaniak, Alicja, Maj, Ewa, Moshari, Mahshad, Delgado, Magdalena, Wietrzyk, Joanna, Bartl, Franz, Chambers, Timothy C., Tuszynski, Jack A., Huczyński, Adam

“…[Display omitted] •Successful synthesis of a series of carbamate derivatives of 7-deacetyl-10-thiocolchicine as anticancer agents.•Screening of the synthesized…”
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Identification of the Major Phosphorylation Site in Bcl-xL Induced by Microtubule Inhibitors and Analysis of Its Functional Significance by Upreti, Meenakshi, Galitovskaya, Elena N., Chu, Rong, Tackett, Alan J., Terrano, David T., Granell, Susana, Chambers, Timothy C.

“…Vinblastine and other microtubule inhibitors used as antimitotic cancer drugs characteristically promote the phosphorylation of the key anti-apoptotic protein,…”
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Small peptide substrates and high resolution peptide gels for the analysis of site-specific protein phosphorylation and dephosphorylation by Battle, Laura Johnson, Chambers, Timothy C

“…Protein phosphorylation and dephosphorylation reactions play key regulatory roles in many fundamental cellular processes. Due to the large number of kinases…”
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Distinct signaling pathways of microtubule inhibitors - vinblastine and Taxol induce JNK-dependent cell death but through AP-1-dependent and AP-1-independent mechanisms, respectively by Kolomeichuk, Sergey N, Terrano, David T, Lyle, Christopher S, Sabapathy, Kanaga, Chambers, Timothy C

“…Vinblastine and paclitaxel (Taxol) are widely used chemotherapeutic drugs that inhibit the normal function of microtubules causing mitotic arrest and cell…”
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Phosphoproteomics Provides Novel Insights into the Response of Primary Acute Lymphoblastic Leukemia Cells to Microtubule Depolymerization in G1 Phase of the Cell Cycle by Delgado, Magdalena, Washam, Charity L, Urbaniak, Alicja, Heflin, Billie, Storey, Aaron J, Lan, Renny S, Mackintosh, Samuel G, Tackett, Alan J, Byrum, Stephanie D, Chambers, Timothy C

“…Microtubule targeting agents (MTAs) have been used for the treatment of cancer for many decades and are among the most successful chemotherapeutic agents…”
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Contrasting effects of microtubule destabilizers versus stabilizers on induction of death in G1 phase of the cell cycle by Delgado, Magdalena, Urbaniak, Alicja, Chambers, Timothy C.

“…[Display omitted] Microtubule targeting agents (MTAs) have been reported to manifest their cytotoxic effects not only in mitosis but also in interphase…”
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Key role for Bak activation and Bak-Bax interaction in the apoptotic response to vinblastine by Upreti, Meenakshi, Chu, Rong, Galitovskaya, Elena, Smart, Sherri K, Chambers, Timothy C

“…Microtubule inhibitors such as vinblastine cause mitotic arrest and subsequent apoptosis through the intrinsic mitochondrial pathway. However, although Bcl-2…”
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Microtubules play an essential role in the survival of primary acute lymphoblastic leukemia cells advancing through G1 phase by Delgado, Magdalena, Chambers, Timothy C.

“…We recently reported that primary acute lymphoblastic leukemia (ALL) cells are susceptible to the microtubule depolymerizing agent vincristine (VCR) in G1…”
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The JNK, ERK and p53 pathways play distinct roles in apoptosis mediated by the antitumor agents vinblastine, doxorubicin, and etoposide by Brantley-Finley, Cheryl, Lyle, Christopher S., Du, Lihua, Goodwin, Mary E., Hall, Toria, Szwedo, Dominika, Kaushal, G.P., Chambers, Timothy C.

“…Assessment of specific apoptosis and survival pathways implicated in anticancer drug action is important for understanding drug mechanisms and modes of…”
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Limitations of an ex vivo breast cancer model for studying the mechanism of action of the anticancer drug paclitaxel by Urbaniak, Alicja, Piña-Oviedo, Sergio, Yuan, Youzhong, Huczyński, Adam, Chambers, Timothy C.

“…Paclitaxel is widely used in the treatment of breast, ovarian, lung, and other cancers. Its primary mechanism is to prevent microtubule depolymerization…”
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Vinblastine-induced Apoptosis Is Mediated by Discrete Alterations in Subcellular Location, Oligomeric Structure, and Activation Status of Specific Bcl-2 Family Members by Upreti, Meenakshi, Lyle, Christopher S., Skaug, Brian, Du, Lihua, Chambers, Timothy C.

“…To gain a broader insight into the role of Bcl-2 proteins in apoptosis induced after mitotic arrest, we investigated the subcellular location, oligomeric…”
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Synthesis and anticancer activity of sclerophytin-inspired hydroisobenzofurans by David Bateman, T., Joshi, Aarti L., Moon, Kwangyul, Galitovskaya, Elena N., Upreti, Meenakshi, Chambers, Timothy C., McIntosh, Matthias C.

“…Seco analogs of sclerophytin A prepared in three or four steps exhibit sub-micromolar growth inhibitory activity against the RPMI-8226 leukemia and HOP-92…”
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Cyclin-dependent Kinase-1 (Cdk1)/Cyclin B1 Dictates Cell Fate after Mitotic Arrest via Phosphoregulation of Antiapoptotic Bcl-2 Proteins by Sakurikar, Nandini, Eichhorn, Joshua M., Chambers, Timothy C.

“…The prevailing model suggests that cell fate after mitotic arrest depends on two independent and competing networks that control cyclin B1 degradation and the…”
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Molecular analysis of functional redundancy among anti-apoptotic Bcl-2 proteins and its role in cancer cell survival by Eichhorn, Joshua M., Alford, Sarah E., Sakurikar, Nandini, Chambers, Timothy C.

“…Bcl-2 family proteins act as essential regulators and mediators of intrinsic apoptosis. Several lines of evidence suggest that the anti-apoptotic members of…”
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