Search Results - "Chambers, J. David"

Cardioplegia and cardiac surgery: pharmacological arrest and cardioprotection during global ischemia and reperfusion by Chambers, David J, Fallouh, Hazem B

“…Since the start of cardiac surgery in the 1950s, multiple techniques have been used to protect the heart during the surgical requirement for elective global…”
Get full text

Efficacy of esmolol cardioplegia during hypothermic ischaemia by Nishina, Dai, Chambers, David J

“…Abstract OBJECTIVES Cardioplegic arrest using a polarizing solution has been shown to have beneficial advantages for cardioprotection compared with…”
Get full text

Lung injury after simulated cardiopulmonary bypass in an isolated perfused rat lung preparation: Role of mitogen-activated protein kinase/Akt signaling and the effects of theophylline by Markou, Thomais, PhD, Chambers, David J., PhD

“…Objectives Lung deflation and inflation during cardiac surgery with cardiopulmonary bypass contributes to pulmonary dysfunction postoperatively. Theophylline…”
Get full text

“Propofol cardioplegia” and myocardial protection: What's in a name by Chambers, David J., BSc, PhD

Get full text

Commentary: Plasma exchange during extended normothermic ex vivo perfusion of donor hearts may lead to the Holy Grail of nonemergency transplantation by Chambers, David J.

Get full text

Commentary: Heat shock protein 90 inhibition and donor heart protection—a paradoxical concept? by Chambers, David J.

Get full text

Myocardial or endothelial protection! Preferably both, but is that achievable with current cardioplegic solutions? by Chambers, David J

Get full text

The importance of conducting relevant animal studies to advance cardioprotection for cardiac surgery by Chambers, David J

Get full text

Future Perspective of Cardioplegic Protection in Cardiac Surgery by Maruyama, Yuji, Chambers, David J, Ochi, Masami

“…"Depolarized arrest", induced by hyperkalemic (moderately increased extracellular potassium) cardioplegia is the gold standard to achieve elective temporary…”
Get full text

Myocardial Infarction Comes Into the Cold by Chambers, David J., PhD

Get full text

Esmolol cardioplegia: the cellular mechanism of diastolic arrest by Fallouh, Hazem B., Bardswell, Sonya C., McLatchie, Linda M., Shattock, Michael J., Chambers, David J., Kentish, Jonathan C.

“…Aims Esmolol, an ultra-short-acting β-blocker, acts as a cardioplegic agent at millimolar concentrations. We investigated the mechanism by which esmolol…”
Get full text

Mechanisms and alternative methods of achieving cardiac arrest by Chambers, David J

“…Elective cardiac arrest during surgery can be achieved by inducing depolarization, polarization, or influencing calcium mechanisms. Depolarized arrest, induced…”
Get full text

“The use of animals in research will …. be necessary to help drive scientific discovery in” (cardiac surgery) by Santer, David, Chambers, David J., Podesser, Bruno K.

Get full text

St Thomas' Hospital polarizing blood cardioplegia improves hemodynamic recovery in a porcine model of cardiopulmonary bypass by Santer, David, Kramer, Anne, Kiss, Attila, Aumayr, Klaus, Hackl, Matthias, Heber, Stefan, Chambers, David J., Hallström, Seth, Podesser, Bruno K.

“…Cardiac surgery demands highly effective cardioprotective regimens. We previously demonstrated improved cardioprotection with “polarized” compared with…”
Get full text

Stereospecific Synthesis of 1,2-cis Glycosides by Vinyl-Mediated IAD by Chayajarus, Kampanart, Chambers, David J, Chughtai, Majid J, Fairbanks, Antony J

“…Stereospecific 1,2-cis glycosylation of 2-O-vinyl thioglycosides, synthesized from the corresponding alcohols by Ir-catalyzed transvinylation with vinyl…”
Get full text

Reply to Choi and Stamm by Aass, Terje, Chambers, David J, Haaverstad, Rune, Grong, Ketil

Get full text

Cardioprotection with esmolol cardioplegia: efficacy as a blood-based solution by Fujii, Masahiro, Chambers, David J.

“…OBJECTIVES Current cardiac surgery patients are older, sicker, with more diffuse disease and hence a reduced tolerance to ischaemia-reperfusion injury. We…”
Get full text

Statistical primer: performing repeated-measures analysis by Hickey, Graeme L, Mokhles, Mostafa M, Chambers, David J, Kolamunnage-Dona, Ruwanthi

“…Abstract Longitudinal data arise when repeated measurements are taken on the same individuals over time. Inference about between-group differences of…”
Get full text

Normothermic blood polarizing versus depolarizing cardioplegia in a porcine model of cardiopulmonary bypass by Kramer, Anne-Margarethe, Kiss, Attila, Heber, Stefan, Chambers, David J, Hallström, Seth, Pilz, Patrick M, Podesser, Bruno K, Santer, David

“…Abstract OBJECTIVES We have previously demonstrated beneficial cardiac protection with hypothermic polarizing cardioplegia compared to a hyperkalemic…”
Get full text

Stereoselective 1,2-cis Glycosylation of 2-O-Allyl Protected Thioglycosides by Aloui, Mahmoud, Chambers, David J., Cumpstey, Ian, Fairbanks, Antony J., Redgrave, Alison J., Seward, Christopher M. P.

“…The technique of intramolecular aglycon delivery (IAD), whereby a glycosyl acceptor is temporarily appended to a hydroxyl group of a glycosyl donor is an…”
Get full text