Search Results - "Chambers, Emma S"

Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition by Pereira, Branca I., Devine, Oliver P., Vukmanovic-Stejic, Milica, Chambers, Emma S., Subramanian, Priya, Patel, Neil, Virasami, Alex, Sebire, Neil J., Kinsler, Veronica, Valdovinos, Alexis, LeSaux, Claude Jourdan, Passos, João F., Antoniou, Antony, Rustin, Malcom H. A., Campisi, Judith, Akbar, Arne N.

“…Senescent cells accumulate in human tissues during ageing and contribute to age-related pathologies. The mechanisms responsible for their accumulation are…”
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Enhancement of cutaneous immunity during aging by blocking p38 mitogen-activated protein (MAP) kinase–induced inflammation by Vukmanovic-Stejic, Milica, Chambers, Emma S., Suárez-Fariñas, Mayte, Sandhu, Daisy, Fuentes-Duculan, Judilyn, Patel, Neil, Agius, Elaine, Lacy, Katie E., Turner, Carolin T., Larbi, Anis, Birault, Veronique, Noursadeghi, Mahdad, Mabbott, Neil A., Rustin, Malcolm H.A., Krueger, James G., Akbar, Arne N.

“…Immunity decreases with age, which leads to reactivation of varicella zoster virus (VZV). In human subjects age-associated immune changes are usually measured…”
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Enhanced production of IL-17A in patients with severe asthma is inhibited by 1α,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion by Nanzer, Alexandra M., MRCP, Chambers, Emma S., MSc, Ryanna, Kimuli, MRCP, Richards, David F., MSc, Black, Cheryl, PhD, Timms, Peter M., FRCPath, Martineau, Adrian R., PhD, Griffiths, Christopher J., FRCGP, Corrigan, Christopher J., PhD, Hawrylowicz, Catherine M., PhD

“…Background TH 17 cells are proposed to play a role in the pathology of asthma, including steroid-resistant (SR) disease. We previously identified a…”
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Correlation Between Postvaccination Anti-Spike Antibody Titers and Protection Against Breakthrough Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Population-Based Longitudinal Study by Vivaldi, Giulia, Jolliffe, David A, Faustini, Sian, Shields, Adrian M, Holt, Hayley, Perdek, Natalia, Talaei, Mohammad, Tydeman, Florence, Chambers, Emma S, Cai, Weigang, Li, Wenhao, Gibbons, Joseph M, Pade, Corinna, McKnight, Áine, Shaheen, Seif O, Richter, Alex G, Martineau, Adrian R

“…In this population-based cohort of 7538 adults, combined immunoglobulin (Ig) G, IgA, and IgM (IgG/A/M) anti-spike titers measured after severe acute…”
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Vitamin D Supplementation Does Not Influence SARS-CoV-2 Vaccine Efficacy or Immunogenicity: Sub-Studies Nested within the CORONAVIT Randomised Controlled Trial by Jolliffe, David A, Vivaldi, Giulia, Chambers, Emma S, Cai, Weigang, Li, Wenhao, Faustini, Sian E, Gibbons, Joseph M, Pade, Corinna, Coussens, Anna K, Richter, Alex G, McKnight, Áine, Martineau, Adrian R

“…Vitamin D deficiency has been reported to associate with the impaired development of antigen-specific responses following vaccination. We aimed to determine…”
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Exploring the Evidence for an Immunomodulatory Role of Vitamin D in Juvenile and Adult Rheumatic Disease by Zou, Jiaqi, Thornton, Clare, Chambers, Emma S, Rosser, Elizabeth C, Ciurtin, Coziana

“…Vitamin D is synthesized in the skin following exposure to UVB radiation or is directly absorbed from the diet. Following hydroxylation in the liver and…”
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Skin barrier immunity and ageing by Chambers, Emma S., Vukmanovic‐Stejic, Milica

“…Summary The skin is the outermost layer of the body with an extensive surface area of approximately 1·8 m2, and is the first line of defence against a…”
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Circulating Senescent T Cells Are Linked to Systemic Inflammation and Lesion Size During Human Cutaneous Leishmaniasis by Covre, Luciana P, Martins, Régia F, Devine, Oliver P, Chambers, Emma S, Vukmanovic-Stejic, Milica, Silva, Juliana A, Dietze, Reynaldo, Rodrigues, Rodrigo R, de Matos Guedes, Herbert L, Falqueto, Aloísio, Akbar, Arne N, Gomes, Daniel C O

“…induces American tegumentary leishmaniasis that ranges in severity from the milder form, cutaneous (CL) to severe disseminated cutaneous leishmaniasis…”
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Recruitment of inflammatory monocytes by senescent fibroblasts inhibits antigen-specific tissue immunity during human aging by Chambers, Emma S., Vukmanovic-Stejic, Milica, Shih, Barbara B., Trahair, Hugh, Subramanian, Priya, Devine, Oliver P., Glanville, James, Gilroy, Derek, Rustin, Malcolm H. A., Freeman, Tom C., Mabbott, Neil A., Akbar, Arne N.

“…We have previously shown that healthy older adults exhibit reduced cutaneous immune responses during a varicella zoster virus (VZV) antigen challenge that…”
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Influence of individuals’ determinants including vaccine type on cellular and humoral responses to SARS-CoV-2 vaccination by Chambers, Emma S., Cai, Weigang, Vivaldi, Giulia, Jolliffe, David A., Perdek, Natalia, Li, Wenhao, Faustini, Sian E., Gibbons, Joseph M., Pade, Corinna, Richter, Alex G., Coussens, Anna K., Martineau, Adrian R.

“…Vaccine development targeting SARS-CoV-2 in 2020 was of critical importance in reducing COVID-19 severity and mortality. In the U.K. during the initial…”
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The effects of calcitriol treatment in glucocorticoid-resistant asthma by Nanzer, Alexandra M., MRCP, Chambers, Emma S., PhD, Ryanna, Kimuli, MRCP, Freeman, Anna T., MRCP, Colligan, Grainne, BSc, Richards, David F., MSc, Timms, Peter M., FRCPath, Martineau, Adrian R., PhD, Griffiths, Christopher J., FRCGP, Corrigan, Christopher J., PhD, Hawrylowicz, Catherine M., PhD

“…A number of mechanisms have been proposed to contribute to glucocorticoid-resistant asthma, including increased expression of nuclear factor kappa B and…”
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The impact of ageing on monocytes and macrophages by De Maeyer, Roel P.H., Chambers, Emma S.

“…•Chronic low-grade inflammation – inflammageing- is observed with age.•Macrophages and monocytes are central to the development of inflammageing.•In this…”
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Serum 25-dihydroxyvitamin D levels correlate with CD4+ Foxp3+ T-cell numbers in moderate/severe asthma by Chambers, Emma S., MSc, Nanzer, Alexandra M., MRCP, Richards, David F., MSc, Ryanna, Kimuli, MRCP, Freeman, Anna T., MRCP, Timms, Peter M., FRCPath, Martineau, Adrian R., PhD, Griffiths, Christopher J., FRCGP, Corrigan, Christopher J., PhD, Hawrylowicz, Catherine M., PhD

“…Corticosteroids enhance the production of the antiinflammatory cytokine IL-10 by T cells in vitro, but notably this response is impaired in cultures from SR…”
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Can blocking inflammation enhance immunity during aging? by Chambers, Emma S., Akbar, Arne N.

“…Aging is a global burden, and the increase in life span does not increase in parallel with health span. Therefore, older adults are currently living longer…”
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Distinct endotypes of steroid-resistant asthma characterized by IL-17Ahigh and IFN-γhigh immunophenotypes: Potential benefits of calcitriol by Chambers, Emma S., PhD, Nanzer, Alexandra M., MRCP, Pfeffer, Paul E., MRCP, Richards, David F., MSc, Timms, Peter M., FRCPath, Martineau, Adrian R., PhD, Griffiths, Christopher J., FRCGP, Corrigan, Christopher J., PhD, Hawrylowicz, Catherine M., PhD

“…Background A small population of patients with severe asthma does not respond to glucocorticoids (steroid resistant [SR]). They have high morbidity,…”
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Human CD8+ EMRA T cells display a senescence‐associated secretory phenotype regulated by p38 MAPK by Callender, Lauren A., Carroll, Elizabeth C., Beal, Robert W. J., Chambers, Emma S., Nourshargh, Sussan, Akbar, Arne N., Henson, Sian M.

“…Summary Cellular senescence is accompanied by a senescence‐associated secretory phenotype (SASP). We show here that primary human senescent CD8+ T cells also…”
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Sestrins induce natural killer function in senescent-like CD8+ T cells by Pereira, Branca I., De Maeyer, Roel P. H., Covre, Luciana P., Nehar-Belaid, Djamel, Lanna, Alessio, Ward, Sophie, Marches, Radu, Chambers, Emma S., Gomes, Daniel C. O., Riddell, Natalie E., Maini, Mala K., Teixeira, Vitor H., Janes, Samuel M., Gilroy, Derek W., Larbi, Anis, Mabbott, Neil A., Ucar, Duygu, Kuchel, George A., Henson, Sian M., Strid, Jessica, Lee, Jun H., Banchereau, Jacques, Akbar, Arne N.

“…Aging is associated with remodeling of the immune system to enable the maintenance of life-long immunity. In the CD8 + T cell compartment, aging results in the…”
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Distinct endotypes of steroid-resistant asthma characterized by IL-17A(high) and IFN-γ(high) immunophenotypes: Potential benefits of calcitriol by Chambers, Emma S, Nanzer, Alexandra M, Pfeffer, Paul E, Richards, David F, Timms, Peter M, Martineau, Adrian R, Griffiths, Christopher J, Corrigan, Christopher J, Hawrylowicz, Catherine M

“…A small population of patients with severe asthma does not respond to glucocorticoids (steroid resistant [SR]). They have high morbidity, highlighting an…”
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The Impact of Vitamin D on Regulatory T Cells by Chambers, Emma S., Hawrylowicz, Catherine M.

“…Epidemiologic studies highlight the increasing prevalence of vitamin D deficiency and insufficiency and its association with an increased risk of autoimmune…”
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Cellular senescence as a possible link between prostate diseases of the ageing male by Fiard, Gaelle, Stavrinides, Vasilis, Chambers, Emma S., Heavey, Susan, Freeman, Alex, Ball, Rhys, Akbar, Arne N., Emberton, Mark

“…Senescent cells accumulate with age in all tissues. Although senescent cells undergo cell-cycle arrest, these cells remain metabolically active and their…”
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