Susceptibility of domestic dogs and cats to Australian bat lyssavirus (ABLV)

The susceptibility of cats and dogs to Australian bat lyssavirus (ABLV; genotype VII) was investigated by intramuscular (IM) inoculation of 10 3.7–10 5 50% tissue culture infective doses (TCID 50) of virus followed by observation of experimental animals for up to 3 months post-inoculation (pi). Each...

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Published in:	Veterinary microbiology Vol. 123; no. 1; pp. 15 - 25
Main Authors:	McColl, Kenneth A., Chamberlain, Tamasine, Lunt, Ross A., Newberry, Kim M., Westbury, Harvey A.
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 20-07-2007 Elsevier Science
Subjects:	Animals Antibodies, Viral - blood antibody detection antigen detection Australian bat lyssavirus Biological and medical sciences Cat Diseases - virology Cats Cats - virology Chiroptera - virology disease resistance Disease Susceptibility - veterinary Dog Diseases - virology Dogs Dogs - virology Eptesicus Fundamental and applied biological sciences. Psychology Genotypes Glycoproteins - genetics inoculum intramuscular injection Lyssavirus Lyssavirus - pathogenicity Lyssavirus - physiology Male Mice Microbiology Miscellaneous pets Rabies virus Rhabdoviridae Infections - veterinary RNA, Viral - blood seroconversion signs and symptoms (animals and humans) Susceptibility Time Factors viral challenge Viral Proteins - genetics Virology virus replication Australia Cats Susceptibility Dogs Lyssavirus Rabies virus Australian bat lyssavirus Genotypes Fissipedia Carnivora Microbiology Genotype Virus Mononegavirales Vertebrata Sensitivity Mammalia Rhabdoviridae Veterinary Dog Chiroptera
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Summary:	The susceptibility of cats and dogs to Australian bat lyssavirus (ABLV; genotype VII) was investigated by intramuscular (IM) inoculation of 10 3.7–10 5 50% tissue culture infective doses (TCID 50) of virus followed by observation of experimental animals for up to 3 months post-inoculation (pi). Each experiment also included positive and negative controls, animals inoculated with a bat variant of rabies virus (Eptesicus I, genotype I), or a 10% suspension of uninfected mouse brain, respectively. Each of the ABLV-inoculated cats showed occasional abnormal clinical signs, but none died. Necropsies performed at 3 months pi revealed no lesions, and no viral antigen, in the central nervous system of any cat. ABLV could not be recovered from any cats. However, rabies virus-neutralizing antibodies were detected between 4 and 14 weeks pi in the sera of all three ABLV-inoculated cats. At 2–3 weeks pi, three of the five ABLV-inoculated dogs showed very mild abnormal clinical signs that persisted for 1–2 days, after which the dogs recovered. At 3 months pi, when all dogs were necropsied, neither lesions nor ABLV antigen were detected in, and virus was not isolated from, any dog. No ABLV RNA was detected by polymerase chain reaction (PCR) in clinical or necropsy samples from the three ABLV-affected dogs. However, all ABLV-inoculated dogs seroconverted by 2 weeks pi, and serum antibody titres were higher than those observed in cats. CSF, collected at 3 months pi, was positive for rabies virus-neutralizing antibody in two ABLV-inoculated dogs.
Bibliography:	http://dx.doi.org/10.1016/j.vetmic.2007.03.024 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0378-1135 1873-2542
DOI:	10.1016/j.vetmic.2007.03.024