Search Results - "Chamberlain, John W"

Transgenic Expression in Mouse Lung Reveals Distinct Biological Roles for the Adenovirus Type 5 E1A 243- and 289-Amino-Acid Proteins by Yang, Yongping, McKerlie, Colin, Borenstein, Steven H, Lu, Zhan, Schito, Marco, Chamberlain, John W, Buchwald, Manuel

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Strong memory CD8 + T cell responses against immunodominant and three new subdominant HLA-B27-restricted influenza A CTL epitopes following secondary infection of HLA-B27 transgenic mice by Cheuk, Eve, Chamberlain, John W.

“…We previously showed that the known HLA-B27-restricted influenza A epitope identified from human studies, NP.383–391, was recognized by CTLs following…”
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Highly conserved pattern of recognition of influenza A wild-type and variant CD8 + CTL epitopes in HLA-A2 + humans and transgenic HLA-A2 +/H2 class I-deficient mice by Hu, Ningjie, D'Souza, Celine, Cheung, Heidi, Lang, Haili, Cheuk, Eve, Chamberlain, John W.

“…As an in vivo model for studying human MHC (HLA) class I-restricted CTL responses to viral infection, we established a series of HLA Tg mice expressing HLA-A2,…”
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Influence of Xenogeneic β2-Microglobulin on Functional Recognition of H-2Kb by the NK Cell Inhibitory Receptor Ly49C by Benoit, Loralyn A., Shannon, John, Chamberlain, John W., Miller, Richard G.

“…Abstract NK cells maintain self-tolerance through expression of inhibitory receptors that bind MHC class I (MHC-I) molecules. MHC-I can exist on the cell…”
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Human MHC Class I Transgenic Mice Deficient for H2 Class I Expression Facilitate Identification and Characterization of New HLA Class I-Restricted Viral T Cell Epitopes by Cheuk, Eve, D'Souza, Celine, Hu, Ningjie, Liu, Youan, Lang, Haili, Chamberlain, John W

“…Although mice transgenic (Tg) for human MHC (HLA) class I alleles could provide an important model for characterizing HLA-restricted viral and tumor Ag CTL…”
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Induction of xenogeneic neonatal tolerance to transgenic human leukocyte antigen class I grafts by BORENSTEIN, Steven H, TAO, Kesheng S, NINGJIE HU, WEST, Lori J, CHAMBERLAIN, John W

“…The immune response against xenografts is vigorous and poorly controlled with conventional immunosuppressants. Therefore, success in xenotransplantation will…”
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Regulation of Meiotic Chromatin Loop Size by Chromosomal Position by Henry H. Q. Heng, Chamberlain, John W., Shi, Xiao-Mei, Spyropoulos, Barbara, Tsui, Lap-Chee, Moens, Peter B.

“…At meiotic prophase, chromatin loops around a proteinaceous core, with the sizes of these loops varying between species. Comparison of the morphology of…”
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CD8+ T Cells Are Necessary for Recognition of Allelic, But Not Locus-Mismatched or Xeno-, HLA Class I Transplantation Antigens by Borenstein, Steven H, Graham, Jeremy, Zhang, Xiao-Li, Chamberlain, John W

“…Although HLA transgenic mice (HLA TgM) could provide a powerful approach to investigate human MHC-specific T cell responsiveness, the extent to which these…”
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Extrathymic deletion of CD8+ alloreactive T cells in a transgenic T cell receptor model of neonatal tolerance by BORENSTEIN, Steven H, TAO, Keshung S, WEST, Lori J, CHAMBERLAIN, John W

“…Immunological tolerance to foreign antigen is most easily achieved during the neonatal period. Although deletion of T cells has been demonstrated in neonatal…”
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Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail by Seong, Rho H, Chamberlain, John W, Parnes, Jane R

“…Mature T cells express either CD4 or CD8 on their surface. Most helper T cells express CD4, which binds to class II major histocompatibility complex (MHC)…”
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NK Cells from Human MHC Class I (HLA-B) Transgenic Mice Do Not Mediate Hybrid Resistance Killing Against Parental Nontransgenic cells by Kung, Sam K. P, Su, Ruey-Chyi, Graham, Jeremy J. K, Chamberlain, John W, Miller, Richard G

“…We have investigated the capacity of human MHC class I HLA-B gene products, HLA-B27, -B7 (fully human), and -B7kb (human-mouse hybrid consisting of the alpha1…”
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Influence of xenogeneic beta2-microglobulin on functional recognition of H-2Kb by the NK cell inhibitory receptor Ly49C by Benoit, Loralyn A, Shannon, John, Chamberlain, John W, Miller, Richard G

“…NK cells maintain self-tolerance through expression of inhibitory receptors that bind MHC class I (MHC-I) molecules. MHC-I can exist on the cell surface in…”
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Influence of Xenogeneic beta sub(2)-Microglobulin on Functional Recognition of H-2K super(b) by the NK Cell Inhibitory Receptor Ly49C by Benoit, Loralyn A, Shannon, John, Chamberlain, John W, Miller, Richard G

“…NK cells maintain self-tolerance through expression of inhibitory receptors that bind MHC class I (MHC-I) molecules. MHC-I can exist on the cell surface in…”
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Highly conserved pattern of recognition of influenza A wild-type and variant CD8 super(+) CTL epitopes in HLA-A2 super(+) humans and transgenic HLA-A2 super(+)/H2 class I-deficient mice by Hu, Ningjie, DSouza, Celine, Cheung, Heidi, Lang, Haili, Cheuk, Eve, Chamberlain, John W

“…As an in vivo model for studying human MHC (HLA) class I-restricted CTL responses to viral infection, we established a series of HLA Tg mice expressing HLA-A2,…”
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EXTRATHYMIC DELETION OF CD8+ ALLOREACTIVE T CELLS IN A TRANSGENIC T CELL RECEPTOR MODEL OF NEONATAL TOLERANCE1 by Borenstein, Steven H., Tao, Keshung S., West, Lori J., Chamberlain, John W.

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A 150-base pair 5' region of the MHC class I HLA-B7 gene is sufficient to direct tissue-specific expression and locus control region activity: the alpha site determines efficient expression and in vivo occupancy at multiple cis-active sites throughout this region by Kushida, MM, Dey, A, Zhang, XL, Campbell, J, Heeney, M, Carlyle, J, Ganguly, S, Ozato, K, Vasavada, H, Chamberlain, JW

“…To characterize cis- and trans-acting mechanisms that regulate MHC class I transcription during development and in adult tissues, we have used transgenic mice…”
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Traumatic hemobilia by SOULIOTIS, P T, PETTGREW, A H, CHAMBERLAIN, J W

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Distinct stage-specific cis-active transcriptional mechanisms control expression of T cell coreceptor CD8 alpha at double- and single-positive stages of thymic development by Zhang, X L, Seong, R, Piracha, R, Larijani, M, Heeney, M, Parnes, J R, Chamberlain, J W

“…Developing thymocytes that give rise to CD8+ (cytotoxic) and CD4+ (helper) alpha beta-TCR T lymphocytes go through progressive stages of expression of…”
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Successful treatment of neuroblastoma; report of two cases with apparent cures by HUDSON, Jr, H W, CHAMBERLAIN, J W, BECKER, F B

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Time-dependent induction of protective anti-influenza immune responses in human peripheral blood lymphocyte/SCID mice by Albert, SE, McKerlie, C, Pester, A, Edgell, BJ, Carlyle, J, Petric, M, Chamberlain, JW

“…The human (hu) PBL/SCID mouse model has the potential to provide a powerful tool for the study of human immune function. However, at peak engraftment (4-8 wk…”
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