Search Results - "Chamberlain, Bruce"

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    Methylnaltrexone for Opioid-Induced Constipation in Advanced Illness by Thomas, Jay, Karver, Sloan, Cooney, Gail Austin, Chamberlain, Bruce H, Watt, Charles Kevin, Slatkin, Neal E, Stambler, Nancy, Kremer, Alton B, Israel, Robert J

    Published in The New England journal of medicine (29-05-2008)
    “…This study investigated the safety and efficacy of subcutaneous methylnaltrexone, a μ-opioid–receptor antagonist, for treating opioid-induced constipation in…”
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    Journal Article
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    Methylnaltrexone Treatment for Opioid-Induced Constipation in Patients with and without Cancer: Effect of Initial Dose by Chamberlain, Bruce H, Rhiner, Michelle, Slatkin, Neal E, Stambler, Nancy, Israel, Robert J

    Published in Journal of pain research (31-08-2023)
    “…Opioid-induced constipation (OIC) is a common side effect of opioid therapy. Methylnaltrexone (MNTX) is a selective, peripherally acting μ-opioid receptor…”
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    Journal Article
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    Methylnaltrexone Treatment of Opioid-Induced Constipation in Patients with Advanced Illness by Chamberlain, Bruce H., MD, Cross, Karen, MD, Winston, Jaron L., MD, Thomas, Jay, MD, Wang, Wenjin, PhD, Su, Chinyu, MD, Israel, Robert J., MD

    Published in Journal of pain and symptom management (01-11-2009)
    “…Abstract Methylnaltrexone, a peripherally acting mu-opioid receptor antagonist with restricted ability to cross the blood-brain barrier, reverses…”
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    Journal Article
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    Subcutaneous Methylnaltrexone for Treatment of Opioid-Induced Constipation in Cancer versus Noncancer Patients: An Analysis of Efficacy and Safety Variables from Two Studies by Chamberlain, Bruce H, Rhiner, Michelle, Slatkin, Neal E, Stambler, Nancy, Israel, Robert J

    Published in Journal of pain research (01-01-2021)
    “…Methylnaltrexone inhibits opioid-induced constipation (OIC) by binding to peripheral µ-opioid receptors without impacting central opioid receptor mediated…”
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    Journal Article
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    Subcutaneous Methylnaltrexone as Treatment for Opioid-Induced Constipation in Patients with Advanced Cancer and Noncancer Illnesses: A Post Hoc Analysis of Two Clinical Trials by Shah, Eric D, Chamberlain, Bruce H, Rhiner, Michelle, Slatkin, Neil E, Stambler, Nancy, Israel, Robert J

    Published in Journal of pain research (01-01-2023)
    “…To evaluate the efficacy and safety of subcutaneous (SC) methylnaltrexone for opioid-induced constipation (OIC) in patients with and without active cancer. We…”
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    Journal Article
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    Subcutaneous methylnaltrexone for opioid-induced constipation in advanced-illness patients with or without active cancer by Chamberlain, Bruce H, Rhiner, Michelle, Slatkin, Neal E, Stambler, Nancy, Israel, Robert J

    Published in Pain management (01-03-2020)
    “…To evaluate methylnaltrexone for opioid-induced constipation in patients with and without cancer. This analysis comprises two Phase III, multicenter,…”
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    Journal Article
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    Efficacy variables in patients with cancer versus patients without cancer treated with methylnaltrexone or placebo: An analysis of two placebo-controlled studies by Chamberlain, Bruce, Rhiner, Michelle, Slatkin, Neal E, Stambler, Nancy, Israel, Robert Joseph

    Published in Journal of clinical oncology (01-12-2018)
    “…Abstract only 1 Background: A post-hoc analysis of pooled data from two randomized, double-blind studies and their open-label extensions evaluated whether…”
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    Journal Article
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    Subcutaneous Methylnaltrexone as Treatment for Opioid-lnduced Constipation in Patients with Advanced Cancer and Noncancer Illnesses: A Post Hoc Analysis of Two Clinical Trials by Shah, Eric D, Chamberlain, Bruce H, Rhiner, Michelle, Slatkin, Neil E, Stambler, Nancy, Israel, Robert J

    Published in Journal of pain research (28-02-2023)
    “…Purpose: To evaluate the efficacy and safety of subcutaneous (SC) methylnaltrexone for opioid-induced constipation (OIC) in patients with and without active…”
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    Journal Article
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    Relationship between corticosteroid exposure and plasma lipid levels in heart transplant recipients by Becker, D M, Chamberlain, B, Swank, R, Hegewald, M G, Girardet, R, Baughman, K L, Kwiterovich, P O, Pearson, T A, Ettinger, W H, Renlund, D

    Published in The American journal of medicine (01-11-1988)
    “…Accelerated coronary atherosclerosis is a major cause of heart graft failure two years and more after heart transplantation, yet its etiology remains…”
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    Journal Article
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    Methylnaltrexone Treatment for Opioid-Induced Constipation in Patients with and without Cancer: Effect of Initial Dose by Chamberlain, Bruce H, Rhiner, Michelle, Slatkin, Neal E, Stambler, Nancy, Israel, Robert J

    Published in Journal of pain research (01-01-2023)
    “…PurposeOpioid-induced constipation (OIC) is a common side effect of opioid therapy. Methylnaltrexone (MNTX) is a selective, peripherally acting μ-opioid…”
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