Search Results - "Cham, Jason"

Durvalumab-induced myocarditis, myositis, and myasthenia gravis: a case report by Cham, Jason, Ng, Daniel, Nicholson, Laura

“…Abstract Background Immune checkpoint inhibitors are effective therapies for a wide range of malignancies. Their increased use has led to a wide range of…”
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NAIR: Network Analysis of Immune Repertoire by Yang, Hai, Cham, Jason, Neal, Brian Patrick, Fan, Zenghua, He, Tao, Zhang, Li

“…T cells represent a crucial component of the adaptive immune system and mediate anti-tumoral immunity as well as protection against infections, including…”
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6 month serologic response to the Pfizer-BioNTech COVID-19 vaccine among healthcare workers by Cham, Jason, Pandey, Amitabh C, New, Jacob, Huynh, Tridu, Hong, Lee, Orendain, Natalia, Topol, Eric J, Nicholson, Laura J

“…Healthcare workers (HCWs) were among the first group of people vaccinated with the Pfizer-BioNTech Covid-19 vaccine (BNT162b2). Characterization of the…”
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A review of treatments targeting DNA-repair gene defects in metastatic castration resistant prostate cancer by Maslov, Diana V, Sember, Quinne, Cham, Jason, Bhangoo, Munveer

“…Prostate cancer is the most common cancer in men. About 6% of those diagnosed will develop metastatic disease. Unfortunately, metastatic prostate cancer is…”
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Malignant Melanoma With Neuroendocrine Differentiation: A Case Report and Literature Review by Cham, Jason, Shavit, Ayal, Ebrahimi, Aren, Viray, Miguel, Gibbs, Paul, Bhangoo, Munveer S

“…Melanoma has a wide range of histologic variants and cytomorphologic features that make its diagnosis challenging. Melanoma can also rarely have neuroendocrine…”
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Novel Ensemble Feature Selection Approach and Application in Repertoire Sequencing Data by He, Tao, Baik, Jason Min, Kato, Chiemi, Yang, Hai, Fan, Zenghua, Cham, Jason, Zhang, Li

“…The T and B cell repertoire make up the adaptive immune system and is mainly generated through somatic V(D)J gene recombination. Thus, the VJ gene usage may be…”
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Do patients with metastatic pancreatic adenocarcinoma to the lung have improved survival? by Ebrahimi, Aren, Cham, Jason, Puglisi, Leah, De Shadarevian, Melanie, Hermel, David J., Spierling Bagsic, Samantha R., Sigal, Darren

“…Introduction Pancreatic ductal adenocarcinoma (PDAC) is a genetically heterogeneous disease often diagnosed with synchronous metastatic disease involving the…”
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Effects of antineoplastic and immunomodulating agents on postvaccination SARS-CoV-2 breakthrough infections, antibody response, and serological cytokine profile by New, Jacob, Cham, Jason, Smith, Lana, Puglisi, Leah, Huynh, Tridu, Kurian, Sunil, Bagsic, Samantha, Fielding, Russel, Hong, Lee, Reddy, Priya, Eum, Ki Suk, Martin, Allison, Barrick, Bethany, Marsh, Christopher, Quigley, Michael, Nicholson, Laura J, Pandey, Amitabh C

“…BackgroundDespite immunization, patients on antineoplastic and immunomodulating agents have a heightened risk of COVID-19 infection. However, accurately…”
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Combination immunotherapy induces distinct T-cell repertoire responses when administered to patients with different malignancies by Cham, Jason, Zhang, Li, Kwek, Serena, Paciorek, Alan, He, Tao, Fong, Grant, Oh, David Y, Fong, Lawrence

“…BackgroundCTLA-4 blockade with ipilimumab is Food and Drug Administration-approved for melanoma as a monotherapy and has been shown to modulate the circulating…”
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Hospitalization requiring intensive care unit due to SARS-CoV-2 infection correlated with IgM depression and IgG elevation by Tamizuddin, Sara, Cham, Jason, Ghiasi, Yasamin, Borroto, Luis, Cao, Cindy, Orendain, Natalia, Quigley, Michael M, Nicholson, Laura J, Pandey, Amitabh C

“…This study investigated the humoral response against SARS-CoV-2 in patients needing intensive care unit (ICU) care compared with those on general medicine…”
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Targeting the PI3K-AKT-mTOR Pathway in Castration Resistant Prostate Cancer: A Review Article by Cham, Jason, Venkateswaran, Aparajit Ram, Bhangoo, Munveer

“…Prostate cancer is one of leading causes of cancer death among men worldwide. Androgen deprivation therapy is a central part of the prostate cancer treatment…”
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Immune Toxicities Elicted by CTLA-4 Blockade in Cancer Patients Are Associated with Early Diversification of the T-cell Repertoire by Oh, David Y, Cham, Jason, Zhang, Li, Fong, Grant, Kwek, Serena S, Klinger, Mark, Faham, Malek, Fong, Lawrence

“…While immune checkpoint blockade elicits efficacious responses in many patients with cancer, it also produces a diverse and unpredictable number of…”
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Do patients with metastatic pancreatic adenocarcinoma to the lung have improved survival? by Ebrahimi, Aren, Shadarevian, Melanie, Cham, Jason, Hermel, David Jacob, Spierling Bagsic, Samantha R., Sigal, Darren

“…e16257 Background: Pancreatic ductal adenocarcinoma (PDAC) is a genetically heterogeneous disease often diagnosed with synchronous metastatic disease involving…”
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Antineoplastic and immunomodulating agent effects on immunization outcomes by New, Jacob, Cham, Jason, Puglisi, Leah, Smith, Lana, Hong, Lee, Fielding, Russel, Kurian, Sunil, Pandey, Amitabh, Nicholson, Laura

“…1539 Background: Oncologists face a challenge in advising patients on the infection risk associated with antineoplastic and immunomodulating medications, as…”
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Clonotypic Diversification of Intratumoral T Cells Following Sipuleucel-T Treatment in Prostate Cancer Subjects by Sheikh, Nadeem, Cham, Jason, Zhang, Li, DeVries, Todd, Letarte, Simon, Pufnock, Jeff, Hamm, David, Trager, James, Fong, Lawrence

“…Sipuleucel-T is an autologous cellular therapy for asymptomatic, or minimally symptomatic, metastatic castrate-resistant prostate cancer, designed to stimulate…”
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Cross-platform comparison of immune-related gene expression to assess intratumor immune responses following cancer immunotherapy by Zhang, Li, Cham, Jason, Cooley, James, He, Tao, Hagihara, Katsunobu, Yang, Hai, Fan, Frances, Cheung, Alexander, Thompson, Debrah, Kerns, B.J., Fong, Lawrence

“…Neoadjuvant immunotherapy can induce immune responses within the tumor microenvironment. Gene expression can be used to assess responses with limited amounts…”
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3D: diversity, dynamics, differential testing - a proposed pipeline for analysis of next-generation sequencing T cell repertoire data by Zhang, Li, Cham, Jason, Paciorek, Alan, Trager, James, Sheikh, Nadeem, Fong, Lawrence

“…Cancer immunotherapy has demonstrated significant clinical activity in different cancers. T cells represent a crucial component of the adaptive immune system…”
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Evaluating survival in patients with pancreatic adenocarcinoma and lung metastasis by Cham, Jason, Ebrahimi, Aren, Hermel, David Jacob, Spierling Bagsic, Samantha R., Sigal, Darren

“…Abstract only e16237 Background: Pancreatic adenocarcinoma most commonly metastasizes to the liver and peritoneum, yet can occasionally metastasize to the…”
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Abstract 549: Clustering analysis of next-generation sequencing T cell repertoire data in sipuleucel-T treated prostate cancer patients by Zhang, Li, Chakraborty, Sounak, Cham, Jason, Oh, David, Sheikh, Nadeem, Fong, Lawrence

“…Abstract Immunotherapy has demonstrated significant clinical benefit in different cancers. T cells are a crucial component of the adaptive immune system and…”
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Abstract 1694: Systemic granulocyte-macrophage colony-stimulating factor (GM-CSF) treatment increases T cell receptor diversity in localized and metastatic prostate cancer patients by Oh, David Y., Zhang, Li, Cham, Jason, Paciorek, Alan, Klinger, Mark, Faham, Malek, Slovin, Susan F., Fong, Lawrence

“…Abstract Granulocyte-macrophage colony-stimulating factor (GM-CSF) is frequently utilized as an adjuvant in cancer immunotherapies, and has known effects as a…”
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