Search Results - "Cham, Candace M."

Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids by Martinez-Guryn, Kristina, Hubert, Nathaniel, Frazier, Katya, Urlass, Saskia, Musch, Mark W., Ojeda, Patricia, Pierre, Joseph F., Miyoshi, Jun, Sontag, Timothy J., Cham, Candace M., Reardon, Catherine A., Leone, Vanessa, Chang, Eugene B.

“…The gut microbiota play important roles in lipid metabolism and absorption. However, the contribution of the small bowel microbiota of mammals to these…”
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Effects of Diurnal Variation of Gut Microbes and High-Fat Feeding on Host Circadian Clock Function and Metabolism by Leone, Vanessa, Gibbons, Sean M., Martinez, Kristina, Hutchison, Alan L., Huang, Edmond Y., Cham, Candace M., Pierre, Joseph F., Heneghan, Aaron F., Nadimpalli, Anuradha, Hubert, Nathaniel, Zale, Elizabeth, Wang, Yunwei, Huang, Yong, Theriault, Betty, Dinner, Aaron R., Musch, Mark W., Kudsk, Kenneth A., Prendergast, Brian J., Gilbert, Jack A., Chang, Eugene B.

“…Circadian clocks and metabolism are inextricably intertwined, where central and hepatic circadian clocks coordinate metabolic events in response to light-dark…”
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Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation by Zhu, Xiaorong, Messer, Jeannette S, Wang, Yunwei, Lin, Fanfei, Cham, Candace M, Chang, Jonathan, Billiar, Timothy R, Lotze, Michael T, Boone, David L, Chang, Eugene B

“…The intracellular protein HMGB1 is released from cells and acts as a damage-associated molecular pattern molecule during many diseases, including inflammatory…”
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Droplet-based high-throughput cultivation for accurate screening of antibiotic resistant gut microbes by Watterson, William J, Tanyeri, Melikhan, Watson, Andrea R, Cham, Candace M, Shan, Yue, Chang, Eugene B, Eren, A Murat, Tay, Savaş

“…Traditional cultivation approaches in microbiology are labor-intensive, low-throughput, and yield biased sampling of environmental microbes due to ecological…”
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Interferon Regulatory Factor 5 in the Pathogenesis of Systemic Lupus Erythematosus by Cham, Candace M., Ko, Kichul, Niewold, Timothy B.

“…Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple genetic risk factors, high levels of interferon alpha (IFN-α), and the…”
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Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation by Zhong, Xiang, Yu, Jiayao, Frazier, Katya, Weng, Xiaocheng, Li, Yi, Cham, Candace M., Dolan, Kyle, Zhu, Xiaorong, Hubert, Nathaniel, Tao, Yun, Lin, Fanfei, Martinez-Guryn, Kristina, Huang, Yong, Wang, Tian, Liu, Jianzhao, He, Chuan, Chang, Eugene B., Leone, Vanessa

“…Transcriptional regulation of circadian rhythms is essential for lipid metabolic homeostasis, disruptions of which can lead to metabolic diseases. Whether…”
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Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8⁺ T cells by Cham, Candace M, Driessens, Gregory, O'Keefe, James P, Gajewski, Thomas F

“…We recently reported that differentiation of CD8⁺ T cells from the naïve to the effector state involves the upregulation of glucose-dependent metabolism…”
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Epithelial wound healing in inflammatory bowel diseases: the next therapeutic frontier by Liu, Cambrian Y., Cham, Candace M., Chang, Eugene B.

“…Patients with one of the many chronic inflammatory disorders broadly classified as inflammatory bowel disease (IBD) now have a diverse set of immunomodulatory…”
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Peptide YY: A Paneth cell antimicrobial peptide that maintains Candida gut commensalism by Pierre, Joseph F, Peters, Brian M, La Torre, Diana, Sidebottom, Ashley M, Tao, Yun, Zhu, Xiaorong, Cham, Candace M, Wang, Ling, Kambal, Amal, Harris, Katharine G, Silva, Julian F, Zaborina, Olga, Alverdy, John C, Herzog, Herbert, Witchley, Jessica, Noble, Suzanne M, Leone, Vanessa A, Chang, Eugene B

“…The mammalian gut secretes a family of multifunctional peptides that affect appetite, intestinal secretions, and motility whereas others regulate the…”
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High-fat diet disrupts REG3γ and gut microbial rhythms promoting metabolic dysfunction by Frazier, Katya, Kambal, Amal, Zale, Elizabeth A., Pierre, Joseph F., Hubert, Nathaniel, Miyoshi, Sawako, Miyoshi, Jun, Ringus, Daina L., Harris, Dylan, Yang, Karen, Carroll, Katherine, Hermanson, Jake B., Chlystek, John S., Overmyer, Katherine A., Cham, Candace M., Musch, Mark W., Coon, Joshua J., Chang, Eugene B., Leone, Vanessa A.

“…Gut microbial diurnal oscillations are important diet-dependent drivers of host circadian rhythms and metabolism ensuring optimal energy balance. However, the…”
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Glucose availability regulates IFN-gamma production and p70S6 kinase activation in CD8+ effector T cells by Cham, Candace M, Gajewski, Thomas F

“…Differentiation of CD8+ T cells from the naive to the effector state is accompanied by changes in basal gene expression profiles that parallel the acquisition…”
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Michael addition-based probes for ratiometric fluorescence imaging of protein S -depalmitoylases in live cells and tissues by Beck, Michael W, Kathayat, Rahul S, Cham, Candace M, Chang, Eugene B, Dickinson, Bryan C

“…The reversible modification of cysteine residues through thioester formation with palmitate (protein -palmitoylation) is a prevalent chemical modification that…”
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Diet, gut microbes, and genetics in immune function: can we leverage our current knowledge to achieve better outcomes in inflammatory bowel diseases? by Leone, Vanessa A, Cham, Candace M, Chang, Eugene B

“…Highlights • Genetics, environmental factors, microbiota and diet, determine susceptibility to IBD. • Western diet promotes dysbiosis, which can lead to…”
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Mo2008 CD14 Transcriptional Response to Vitamin D Differs Between Proximal and Distal Colon by Mapes, Brandon, Cham, Candace M, Kupfer, Sonia

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Chylomicron-sized lipid particles are formed in the setting of apolipoprotein B deficiency by Hamilton, R L, Wong, J S, Cham, C M, Nielsen, L B, Young, S G

“…The mechanisms for packaging large quantities of neutral lipids into apolipoprotein (apo) B-containing lipoproteins (chylomicrons or VLDL) are incompletely…”
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Transgenic Expression of the Coxsackie/Adenovirus Receptor Enables Adenoviral-Mediated Gene Delivery in Naive T Cells by Wan, Y Y, Leon, R P, Marks, R, Cham, C M, Schaack, J, Gajewski, T F, DeGregori, J

“…The inability to easily and efficiently introduce genes into primary T cells has hampered the investigation of the pathways controlling T cell fate. To enable…”
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Gene Array and Protein Expression Profiles Suggest Post-transcriptional Regulation during CD8+ T Cell Differentiation by Cham, Candace M., Xu, Hui, O'Keefe, James P., Rivas, Fabiola V., Zagouras, Panayiotis, Gajewski, Thomas F.

“…Peripheral CD8 + T cells circulate in a quiescent naive state until they are primed by specific antigen and differentiate into effector cells. In the effector…”
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Correction: Michael addition-based probes for ratiometric fluorescence imaging of protein S-depalmitoylases in live cells and tissues by Beck, Michael W, Kathayat, Rahul S, Cham, Candace M, Chang, Eugene B, Dickinson, Bryan C

“…Correction for 'Michael addition-based probes for ratiometric fluorescence imaging of protein S -depalmitoylases in live cells and tissues' by Michael W. Beck…”
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The gastrin-releasing peptide analog bombesin preserves exocrine and endocrine pancreas morphology and function during parenteral nutrition by Pierre, Joseph F, Neuman, Joshua C, Brill, Allison L, Brar, Harpreet K, Thompson, Mary F, Cadena, Mark T, Connors, Kelsey M, Busch, Rebecca A, Heneghan, Aaron F, Cham, Candace M, Jones, Elaina K, Kibbe, Carly R, Davis, Dawn B, Groblewski, Guy E, Kudsk, Kenneth A, Kimple, Michelle E

“…Stimulation of digestive organs by enteric peptides is lost during total parental nutrition (PN). Here we examine the role of the enteric peptide bombesin…”
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Sa1731 HMGB1 Controls the Intestinal Epithelial Autophagy/Apoptosis Checkpoint During Mucosal Inflammation and IBD by Zhu, Xiaorong, Messer, Jeannette S, Wang, Yunwei, Lin, Fanfei, Cham, Candace M, Chang, Jonathan, Billiar, Timothy, Lotze, Michael T, Boone, David L, Chang, Eugene B

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