Search Results - "Chalupská, Dominika"

Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4‑Kinase IIIβ (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology by Mejdrová, Ivana, Chalupská, Dominika, Plačková, Pavla, Müller, Christin, Šála, Michal, Klíma, Martin, Baumlová, Adriana, Hřebabecký, Hubert, Procházková, Eliška, Dejmek, Milan, Strunin, Dmytro, Weber, Jan, Lee, Gary, Matoušová, Marika, Mertlíková-Kaiserová, Helena, Ziebuhr, John, Birkus, Gabriel, Boura, Evzen, Nencka, Radim

“…Phosphatidylinositol 4-kinase IIIβ (PI4KB) is indispensable for the replication of various positive-sense single stranded RNA viruses, which hijack this…”
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Highly Selective Phosphatidylinositol 4‑Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action by Mejdrová, Ivana, Chalupská, Dominika, Kögler, Martin, Šála, Michal, Plačková, Pavla, Baumlová, Adriana, Hřebabecký, Hubert, Procházková, Eliška, Dejmek, Milan, Guillon, Rémi, Strunin, Dmytro, Weber, Jan, Lee, Gary, Birkus, Gabriel, Mertlíková-Kaiserová, Helena, Boura, Evzen, Nencka, Radim

“…Phosphatidylinositol 4-kinase IIIβ is a cellular lipid kinase pivotal to pathogenesis of various RNA viruses. These viruses hijack the enzyme in order to…”
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Rational Design of Highly Potent SARS-CoV‑2 nsp14 Methyltransferase Inhibitors by Štefek, Milan, Chalupská, Dominika, Chalupský, Karel, Zgarbová, Michala, Dvořáková, Alexandra, Krafčíková, Petra, Li, Alice Shi Ming, Šála, Michal, Dejmek, Milan, Otava, Tomáš, Chaloupecká, Ema, Kozák, Jaroslav, Kozic, Ján, Vedadi, Masoud, Weber, Jan, Mertlíková-Kaiserová, Helena, Nencka, Radim

“…The search for new drugs against COVID-19 and its causative agent, SARS-CoV-2, is one of the major trends in the current medicinal chemistry. Targeting capping…”
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Structural basis of RNA recognition by the SARS-CoV-2 nucleocapsid phosphoprotein by Dinesh, Dhurvas Chandrasekaran, Chalupska, Dominika, Silhan, Jan, Koutna, Eliska, Nencka, Radim, Veverka, Vaclav, Boura, Evzen

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the coronavirus disease 2019 (COVID-19). SARS-CoV-2 is a single-stranded…”
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PI(4,5)P2 controls plasma membrane PI4P and PS levels via ORP5/8 recruitment to ER–PM contact sites by Sohn, Mira, Korzeniowski, Marek, Zewe, James P., Wills, Rachel C., Hammond, Gerald R.V., Humpolickova, Jana, Vrzal, Lukas, Chalupska, Dominika, Veverka, Vaclav, Fairn, Gregory D., Boura, Evzen, Balla, Tamas

“…Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a critically important regulatory lipid of the plasma membrane (PM); however, little is known about how…”
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Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase by Silhan, Jan, Klima, Martin, Otava, Tomas, Skvara, Petr, Chalupska, Dominika, Chalupsky, Karel, Kozic, Jan, Nencka, Radim, Boura, Evzen

“…Monkeypox is a disease with pandemic potential. It is caused by the monkeypox virus (MPXV), a double-stranded DNA virus from the Poxviridae family, that…”
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Structure-based design and modular synthesis of novel PI4K class II inhibitors bearing a 4-aminoquinazoline scaffold by Misehe, Mbilo, Klima, Martin, Matoušová, Marika, Chalupská, Dominika, Dejmek, Milan, Šála, Michal, Mertlíková-Kaiserová, Helena, Boura, Evzen, Nencka, Radim

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Design, synthesis and evaluation of novel thieno[2,3d]pyrimidine derivatives as potent and specific RIPK2 inhibitors by Misehe, Mbilo, Šála, Michal, Matoušová, Marika, Hercík, Kamil, Kocek, Hugo, Chalupská, Dominika, Chaloupecká, Ema, Hájek, Miroslav, Boura, Evzen, Mertlíková-Kaiserová, Helena, Nencka, Radim

“…In human cells, receptor-interacting protein kinase 2 (RIPK2) is mainly known to mediate downstream enzymatic cascades from the nucleotide-binding…”
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Phosphatidylinositol 4-kinase IIIβ (PI4KB) forms highly flexible heterocomplexes that include ACBD3, 14-3-3, and Rab11 proteins by Chalupska, Dominika, Różycki, Bartosz, Humpolickova, Jana, Faltova, Lenka, Klima, Martin, Boura, Evzen

“…Phosphatidylinositol 4-kinase IIIβ (PI4KB) is a key enzyme of the Golgi system because it produces its lipid hallmark - the phosphatidylinositol 4-phosphate…”
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Exploring positions 6 and 7 of a quinazoline-based scaffold leads to changes in selectivity and potency towards RIPK2/3 kinases by Misehe, Mbilo, Matoušová, Marika, Dvořáková, Alexandra, Hercík, Kamil, Škach, Kryštof, Chalupská, Dominika, Dejmek, Milan, Šála, Michal, Hájek, Miroslav, Boura, Evzen, Mertlíková-Kaiserová, Helena, Nencka, Radim

“…Receptor-interacting protein kinases 2 and 3 (RIPK2 and RIPK3) are considered attractive therapeutic enzyme targets for the treatment of a multitude of…”
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Antiviral Properties of the NSAID Drug Naproxen Targeting the Nucleoprotein of SARS-CoV-2 Coronavirus by Terrier, Olivier, Dilly, Sébastien, Pizzorno, Andrés, Chalupska, Dominika, Humpolickova, Jana, Bouřa, Evžen, Berenbaum, Francis, Quideau, Stéphane, Lina, Bruno, Fève, Bruno, Adnet, Frédéric, Sabbah, Michèle, Rosa-Calatrava, Manuel, Maréchal, Vincent, Henri, Julien, Slama-Schwok, Anny

“…There is an urgent need for specific antiviral treatments directed against SARS-CoV-2 to prevent the most severe forms of COVID-19. By drug repurposing,…”
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Structural insights and in vitro reconstitution of membrane targeting and activation of human PI4KB by the ACBD3 protein by Klima, Martin, Tóth, Dániel J., Hexnerova, Rozalie, Baumlova, Adriana, Chalupska, Dominika, Tykvart, Jan, Rezabkova, Lenka, Sengupta, Nivedita, Man, Petr, Dubankova, Anna, Humpolickova, Jana, Nencka, Radim, Veverka, Vaclav, Balla, Tamas, Boura, Evzen

“…Phosphatidylinositol 4-kinase beta (PI4KB) is one of four human PI4K enzymes that generate phosphatidylinositol 4-phosphate (PI4P), a minor but essential…”
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Convergent evolution in the mechanisms of ACBD3 recruitment to picornavirus replication sites by Horova, Vladimira, Lyoo, Heyrhyoung, Różycki, Bartosz, Chalupska, Dominika, Smola, Miroslav, Humpolickova, Jana, Strating, Jeroen R P M, van Kuppeveld, Frank J M, Boura, Evzen, Klima, Martin

“…Enteroviruses, members of the family of picornaviruses, are the most common viral infectious agents in humans causing a broad spectrum of diseases ranging from…”
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Localization of SARS-CoV-2 Capping Enzymes Revealed by an Antibody against the nsp10 Subunit by Horova, Vladimira, Landova, Barbora, Hodek, Jan, Chalupsky, Karel, Krafcikova, Petra, Chalupska, Dominika, Duchoslav, Vojtech, Weber, Jan, Boura, Evzen, Klima, Martin

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the coronavirus disease-19 pandemic. One of the key components of the…”
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A large scale high-throughput screen identifies chemical inhibitors of phosphatidylinositol 4-kinase type II alpha[S] by Sengupta, Nivedita, Jović, Marko, Barnaeva, Elena, Kim, David W., Hu, Xin, Southall, Noel, Dejmek, Milan, Mejdrova, Ivana, Nencka, Radim, Baumlova, Adriana, Chalupska, Dominika, Boura, Evzen, Ferrer, Marc, Marugan, Juan, Balla, Tamas

“…The minor phospholipid, phosphatidylinositol 4-phosphate (PI4P), is emerging as a key regulator of lipid transfer in ER-membrane contact sites. Four different…”
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Adaptation of an L-proline adenylation domain to use 4-propyl-L-proline in the evolution of lincosamide biosynthesis by Kadlčík, Stanislav, Kučera, Tomáš, Chalupská, Dominika, Gažák, Radek, Koběrská, Markéta, Ulanová, Dana, Kopecký, Jan, Kutejová, Eva, Najmanová, Lucie, Janata, Jiří

“…Clinically used lincosamide antibiotic lincomycin incorporates in its structure 4-propyl-L-proline (PPL), an unusual amino acid, while celesticetin, a less…”
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Single-site mutations in the carboxyltransferase domain of plastid acetyl-CoA carboxylase confer resistance to grass-specific herbicides by Liu, Wenjie, Harrison, Dion K, Chalupska, Dominika, Gornicki, Piotr, O'Donnell, Chris C, Adkins, Steve W, Haselkorn, Robert, Williams, Richard R

“…Grass weed populations resistant to aryloxyphenoxypropionate (APP) and cyclohexanedione herbicides that inhibit acetyl-CoA carboxylase (ACCase; EC 6.4.1.2)…”
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Norbornane-based nucleoside and nucleotide analogues locked in North conformation by Dejmek, Milan, Šála, Michal, Hřebabecký, Hubert, Dračínský, Martin, Procházková, Eliška, Chalupská, Dominika, Klíma, Martin, Plačková, Pavla, Hájek, Miroslav, Andrei, Graciela, Naesens, Lieve, Leyssen, Pieter, Neyts, Johan, Balzarini, Jan, Boura, Evzen, Nencka, Radim

“…[Display omitted] We report on the synthesis of novel conformationally locked nucleoside and nucleotide derivatives, which are structurally closely related to…”
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Recombinant yeast screen for new inhibitors of human acetyl-CoA carboxylase 2 identifies potential drugs to treat obesity by Marjanovic, Jasmina, Chalupska, Dominika, Patenode, Caroline, Coster, Adam, Arnold, Evan, Ye, Alice, Anesi, George, Lu, Ying, Okun, Ilya, Tkachenko, Sergey, Haselkorn, Robert, Gornicki, Piotr

“…Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism with multiple isozymes often expressed in different eukaryotic cellular compartments…”
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Structural and functional insights in flavivirus NS5 proteins gained by the structure of Ntaya virus polymerase and methyltransferase by Krejčová, Kateřina, Krafcikova, Petra, Klima, Martin, Chalupska, Dominika, Chalupsky, Karel, Zilecka, Eva, Boura, Evzen

“…Flaviviruses are single-stranded positive-sense RNA (+RNA) viruses that are responsible for several (re)emerging diseases such as yellow, dengue, or West Nile…”
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