Search Results - "Chalmers, R. A."

Influence of sex on expansion rate of abdominal aortic aneurysms by Mofidi, R., Goldie, V. J., Kelman, J., Dawson, A. R. W., Murie, J. A., Chalmers, R. T. A.

“…Background: The UK Small Aneurysm Trial suggested that female sex is an independent risk factor for rupture of abdominal aortic aneurysm (AAA). This study…”
Get full text

Diagnosis and management of trimethylaminuria (FMO3 deficiency) in children by Chalmers, R. A., Bain, M. D., Michelakakis, H., Zschocke, J., Iles, R. A.

“…Summary Persistent trimethylaminuria in children is caused by autosomal recessively inherited impairment of hepatic trimethylamine (TMA) oxidation due to…”
Get full text

In vitro and in vivo studies with human carrier erythrocytes loaded with polyethylene glycol‐conjugated and native adenosine deaminase by Bax, B. E., Bain, M. D., Fairbanks, L. D., Webster, A. D. B., Chalmers, R. A.

“…Polyethylene glycol‐conjugated adenosine deaminase (pegademase) is used for enzyme replacement therapy for patients with severe combined immunodeficiency…”
Get full text

Real-time continuous glucose monitoring in preterm infants (REACT): an international, open-label, randomised controlled trial by Beardsall, Kathryn, Thomson, Lynn, Guy, Catherine, Iglesias-Platas, Isabel, van Weissenbruch, Mirjam M, Bond, Simon, Allison, Annabel, Kim, Sungwook, Petrou, Stavros, Pantaleo, Beatrice, Hovorka, Roman, Dunger, David

“…Hyperglycaemia and hypoglycaemia are common in preterm infants and have been associated with increased risk of mortality and morbidity. Interventions to reduce…”
Get more information

Glutaryl-CoA dehydrogenase deficiency: region-specific analysis of organic acids and acylcarnitines in post mortem brain predicts vulnerability of the putamen by Kölker, S, Hoffmann, G F, Schor, D S M, Feyh, P, Wagner, L, Jeffrey, I, Pourfarzam, M, Okun, J G, Zschocke, J, Baric, I, Bain, M D, Jakobs, C, Chalmers, R A

“…The neurometabolic disorder glutaryl-CoA dehydrogenase (GCDH) deficiency is biochemically characterised by an accumulation of the marker metabolites…”
Get more information

Randomized clinical trial of tranexamic acid-free fibrin sealant during vascular surgical procedures by Chalmers, R. T. A., Darling III, R. C., Wingard, J. T., Chetter, I., Cutler, B., Kern, J. A., Hart, J. C.

“…Background: This study evaluated the safety and haemostatic effectiveness of a fibrin sealant (EVICEL™ Fibrin Sealant (Human)) during vascular surgery…”
Get full text

D-2-Hydroxyglutaric aciduria: Biochemical marker or clinical disease entity? by Van Der Knaap, M. S., Jakobs, C., Hoffmann, G. F., Nyhan, W. L., Renier, W. O., Smeitink, J. A. M., Catsman-Berrevoets, C. E., Hjalmarson, O., Vallance, H., Sugita, K., Bowe, C. M., Herrin, J. T., Craigen, W. J., Buist, N. R. M., Brookfield, D. S. K., Chalmers, R. A.

“…D‐2‐Hydroxyglutaric aciduria has been observed in patients with extremely variable clinical symptoms, creating doubt about the existence of a disease entity…”
Get full text

Ruptured thoracoabdominal aneurysm in a 27-year-old with hyper IgE syndrome by Falah, Orwa, MRCS(Ed), FRCS(Ed), FRCS(Gen. Surg), Thwaites, Stephen E., MBBS, FRACS, Chalmers, R.T.A., MD, FRCS

“…Hyperimmunoglobulin E syndrome is a rare primary immunodeficiency disorder defined by high serum immunoglobulin E titers and associated with characteristic…”
Get full text

Methylmalonic aciduria: Follow‐up and enzymology on the original case after 36 years by Bain, M. D., Till, J., Jones, M. G., Besley, G. T. N., Lee, P., Oliveira, D., Chalmers, R. A.

“…Summary A 36‐year follow‐up on the original patient described with methylmalonic aciduria has shown that she has methylmalonyl‐CoA apomutase deficiency. The…”
Get full text

Secondary analysis of economic data: a review of cost-benefit studies of neonatal screening for phenylketonuria by Lord, J, Thomason, M J, Littlejohns, P, Chalmers, R A, Bain, M D, Addison, G M, Wilcox, A H, Seymour, C A

“…STUDY OBJECTIVE: To estimate the net financial benefit of neonatal screening for phenylketonuria (PKU): by a simple pooling of cost data from the literature;…”
Get full text

L‐Carnitine and exercise tolerance in medium‐chain acyl‐coenzyme A dehydrogenase (MCAD) deficiency: A pilot study by Lee, P. J., Harrison, E. L., Jones, M. G., Jones, S., Leonard, J. V., Chalmers, R. A.

“…Summary Skeletal muscle function may be impaired in patients with medium‐chain acyl‐CoA dehydrogenase (MCAD) deficiency, but the value of L‐carnitine in their…”
Get full text

Validity of the Glasgow Aneurysm Score and the Hardman Index in predicting outcome after ruptured abdominal aortic aneurysm repair by Tambyraja, A. L., Fraser, S. C. A., Murie, J. A., Chalmers, R. T. A.

“…Background: The Glasgow Aneurysm Score and the Hardman Index have been recommended as predictors of outcome after repair of ruptured abdominal aortic aneurysm…”
Get full text

Rhabdomyolysis and acute encephalopathy in late onset medium chain acyl-CoA dehydrogenase deficiency by Ruitenbeek, W, Poels, P J, Turnbull, D M, Garavaglia, B, Chalmers, R A, Taylor, R W, Gabreëls, F J

“…A previously asymptomatic 30 year old man presented with rhabdomyolysis, muscle weakness, and acute encephalopathy after strenuous exertion in the cold without…”
Get full text

Fibrinogen concentrate vs. fresh frozen plasma for the management of coagulopathy during thoraco‐abdominal aortic aneurysm surgery: a pilot randomised controlled trial by Morrison, G. A., Koch, J., Royds, M., McGee, D., Chalmers, R. T. A., Anderson, J., Nimmo, A. F.

“…Summary Major vascular surgery is frequently associated with significant blood loss and coagulopathy. Existing evidence suggests hypofibrinogenaemia develops…”
Get full text

Survival of human carrier erythrocytes in vivo by Bax, B E, Bain, M D, Talbot, P J, Parker-Williams, E J, Chalmers, R A

“…Erythrocytes offer the exciting opportunity of being used as carriers of therapeutic agents. Encapsulation within erythrocytes will give the therapeutic agent…”
Get more information

Urinary excretion of l-carnitine and acylcarnitines by patients with disorders of organic acid metabolism: evidence for secondary insufficiency of l-carnitine by CHALMERS, R. A, ROE, C. R, STACEY, T. E, HOPPEL, C. L

“…Concentrations of l-carnitine and acylcarnitines have been determined in urine from patients with disorders of organic acid metabolism associated with an…”
Get full text

Cardiac troponin I predicts outcome after ruptured abdominal aortic aneurysm repair by Tambyraja, A. L., Dawson, A. R. W., Murie, J. A., Chalmers, R. T. A.

“…Background: Cardiac troponin I (cTnI) is a highly sensitive and specific marker for myocardial injury that predicts mortality in patients with acute coronary…”
Get full text

A systematic review of evidence for the appropriateness of neonatal screening programmes for inborn errors of metabolism by Thomason, Margaret J., Lord, Joanne, Bain, Murray D., Chalmers, Ronald A., Littlejohns, Peter, Addison, G. Michael, Wilcox, A. Hervey, Seymour, Carol A.

“…Background Developments in screening technology and increased understanding of the natural history and treatment of inborn errors of metabolism (IEMs) have…”
Get full text

Use of proton nuclear magnetic resonance spectroscopy in detection and study of organic acidurias by Iles, R A, Hind, A J, Chalmers, R A

“…We used high-resolution proton nuclear magnetic resonance spectroscopy to detect, identify, and study the major normal and abnormal organic acid metabolites in…”
Get more information

Artefacts in organic acid analysis: occurrence and origin of partially trimethylsilylated 3-hydroxy-3-methyl carboxylic acids by Jones, Mark G, Chalmers, Ronald A

“…Previous reports of patients with 3-hydroxy-3-methylglutaric aciduria have described the occurrence of di-trimethylsilyl (TMS) and tri-TMS derivatives of…”
Get full text