Search Results - "Chalmers, Anthony"

Limited Mitochondrial Permeabilization Causes DNA Damage and Genomic Instability in the Absence of Cell Death by Ichim, Gabriel, Lopez, Jonathan, Ahmed, Shafiq U., Muthalagu, Nathiya, Giampazolias, Evangelos, Delgado, M. Eugenia, Haller, Martina, Riley, Joel S., Mason, Susan M., Athineos, Dimitris, Parsons, Melissa J., van de Kooij, Bert, Bouchier-Hayes, Lisa, Chalmers, Anthony J., Rooswinkel, Rogier W., Oberst, Andrew, Blyth, Karen, Rehm, Markus, Murphy, Daniel J., Tait, Stephen W.G.

“…During apoptosis, the mitochondrial outer membrane is permeabilized, leading to the release of cytochrome c that activates downstream caspases. Mitochondrial…”
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A novel 3D human glioblastoma cell culture system for modeling drug and radiation responses by Gomez-Roman, Natividad, Stevenson, Katrina, Gilmour, Lesley, Hamilton, Graham, Chalmers, Anthony J

“…Glioblastoma (GBM) is the most common primary brain tumor, with dismal prognosis. The failure of drug-radiation combinations with promising preclinical data to…”
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Selective Inhibition of Parallel DNA Damage Response Pathways Optimizes Radiosensitization of Glioblastoma Stem-like Cells by Ahmed, Shafiq U, Carruthers, Ross, Gilmour, Lesley, Yildirim, Salih, Watts, Colin, Chalmers, Anthony J

“…Glioblastoma is the most common form of primary brain tumor in adults and is essentially incurable. Despite aggressive treatment regimens centered on…”
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Pharmacokinetics, safety, and tolerability of olaparib and temozolomide for recurrent glioblastoma: results of the phase I OPARATIC trial by Hanna, Catherine, Kurian, Kathreena M, Williams, Karin, Watts, Colin, Jackson, Alan, Carruthers, Ross, Strathdee, Karen, Cruickshank, Garth, Dunn, Laurence, Erridge, Sara, Godfrey, Lisa, Jefferies, Sarah, McBain, Catherine, Sleigh, Rebecca, McCormick, Alex, Pittman, Marc, Halford, Sarah, Chalmers, Anthony J

“…Abstract Background The poly(ADP-ribose) polymerase (PARP) inhibitor olaparib potentiated radiation and temozolomide (TMZ) chemotherapy in preclinical…”
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Practice-changing radiation therapy trials for the treatment of cancer: where are we 150 years after the birth of Marie Curie? by Thompson, Mareike K., Poortmans, Philip, Chalmers, Anthony J., Faivre-Finn, Corinne, Hall, Emma, Huddart, Robert A., Lievens, Yolande, Sebag-Montefiore, David, Coles, Charlotte E.

“…As we mark 150 years since the birth of Marie Curie, we reflect on the global advances made in radiation oncology and the current status of radiation therapy…”
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Glioblastoma's Next Top Model: Novel Culture Systems for Brain Cancer Radiotherapy Research by Caragher, Seamus, Chalmers, Anthony J, Gomez-Roman, Natividad

“…Glioblastoma (GBM), the most common and aggressive primary brain tumor in adults, remains one of the least treatable cancers. Current standard of…”
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Replication Stress Drives Constitutive Activation of the DNA Damage Response and Radioresistance in Glioblastoma Stem-like Cells by Carruthers, Ross D, Ahmed, Shafiq U, Ramachandran, Shaliny, Strathdee, Karen, Kurian, Kathreena M, Hedley, Ann, Gomez-Roman, Natividad, Kalna, Gabriela, Neilson, Mathew, Gilmour, Lesley, Stevenson, Katrina H, Hammond, Ester M, Chalmers, Anthony J

“…Glioblastoma (GBM) is a lethal primary brain tumor characterized by treatment resistance and inevitable tumor recurrence, both of which are driven by a…”
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Towards world-class radiotherapy in the UK: time for transformation by Wakeham, Katie, Cooper, Tim, Rowbottom, Carl, Chalmers, Anthony J, Spencer, Katie, Price, Pat, Quinlan, Sarah

“…The UK has a 15% shortfall of clinical oncologists and, by 2027, this shortfall is predicted to increase to 25%.10 For both therapeutic radiographers and…”
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ESTRO-EANO guideline on target delineation and radiotherapy details for glioblastoma by Niyazi, Maximilian, Andratschke, Nicolaus, Bendszus, Martin, Chalmers, Anthony J, Erridge, Sara C, Galldiks, Norbert, Lagerwaard, Frank J, Navarria, Pierina, Munck af Rosenschöld, Per, Ricardi, Umberto, van den Bent, Martin J, Weller, Michael, Belka, Claus, Minniti, Giuseppe

“…•The present ESTRO-EANO guideline reports the novel standard for target delineation of glioblastoma and refines the ESTRO-ACROP/EORTC standard.•GTV is defined…”
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ESTRO-ACROP guideline “target delineation of glioblastomas” by Niyazi, Maximilian, Brada, Michael, Chalmers, Anthony J, Combs, Stephanie E, Erridge, Sara C, Fiorentino, Alba, Grosu, Anca L, Lagerwaard, Frank J, Minniti, Giuseppe, Mirimanoff, René-Olivier, Ricardi, Umberto, Short, Susan C, Weber, Damien C, Belka, Claus

“…Abstract Background and purpose Target delineation in glioblastoma (GBM) varies substantially between different institutions and several consensus statements…”
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Targeting PARP for Chemoradiosensitization: Opportunities, Challenges, and the Road Ahead by Willers, Henning, Krause, Mechthild, Faivre-Finn, Corinne, Chalmers, Anthony J.

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Replication-Dependent Radiosensitization of Human Glioma Cells by Inhibition of Poly(ADP-Ribose) Polymerase: Mechanisms and Therapeutic Potential by Dungey, Fiona A., B.Sc, Löser, Dana A., M.Sc, Chalmers, Anthony J., F.R.C.R., Ph.D

“…Purpose Current treatments for glioblastoma multiforme are inadequate and limited by the radiation sensitivity of normal brain. Because glioblastoma multiforme…”
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Health economic evaluation of a serum-based blood test for brain tumour diagnosis: exploration of two clinical scenarios by Gray, Ewan, Butler, Holly J, Board, Ruth, Brennan, Paul M, Chalmers, Anthony J, Dawson, Timothy, Goodden, John, Hamilton, Willie, Hegarty, Mark G, James, Allan, Jenkinson, Michael D, Kernick, David, Lekka, Elvira, Livermore, Laurent J, Mills, Samantha J, O’Neill, Kevin, Palmer, David S, Vaqas, Babar, Baker, Matthew J

“…ObjectivesTo determine the potential costs and health benefits of a serum-based spectroscopic triage tool for brain tumours, which could be developed to reduce…”
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Psychosocial and supportive-care needs in high-grade glioma by Catt, Susan, Dr, Chalmers, Anthony, FRCR, Fallowfield, Lesley, Prof

“…Summary The diagnosis and management of high-grade glioma has profound effects on patients and their families. Guidance issued by the UK National Institute of…”
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Radiotherapy-Poly(ADP-ribose) Polymerase Inhibitor Combinations: Progress to Date by Derby, Sarah J., Chalmers, Anthony J., Carruthers, Ross D.

“…Radiation resistance remains a huge clinical problem for cancer patients and oncologists in the 21st century. In recent years, the mammalian DNA damage…”
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Radiation-Induced Transformation of Immunoregulatory Networks in the Tumor Stroma by Martinez-Zubiaurre, Inigo, Chalmers, Anthony J, Hellevik, Turid

“…The implementation of novel cancer immunotherapies in the form of immune checkpoint blockers represents a major advancement in the treatment of cancer, and has…”
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Concurrent Olaparib and Radiation Therapy in Older Patients With Newly Diagnosed Glioblastoma: The Phase 1 Dose-Escalation PARADIGM Trial by Derby, Sarah, Jackson, Mark R., Williams, Karin, Stobo, Jamie, Kelly, Caroline, Sweeting, Lorna, Shad, Shumaila, Herbert, Christopher, Short, Susan C., Williamson, Aoife, James, Allan, Nowicki, Stefan, Bulbeck, Helen, Chalmers, Anthony J.

“…Patients with glioblastoma who are older or have poor performance status (PS) experience particularly poor clinical outcomes. At the time of study initiation,…”
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Evaluation of four different small animal radiation plans on tumour and normal tissue dosimetry in a glioblastoma mouse model by Rutherford, Alasdair, Stevenson, Katrina, Tulk, Amanda, Chalmers, Anthony J

“…Small animal radiotherapy research platforms such as XStrahl's SARRP enable more precise irradiation of tumours and normal tissues in pre-clinical models of…”
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Stereotactic ablative radiotherapy for the comprehensive treatment of 4-10 oligometastatic tumors (SABR-COMET-10): study protocol for a randomized phase III trial by Palma, David A, Olson, Robert, Harrow, Stephen, Correa, Rohann J M, Schneiders, Famke, Haasbeek, Cornelis J A, Rodrigues, George B, Lock, Michael, Yaremko, Brian P, Bauman, Glenn S, Ahmad, Belal, Schellenberg, Devin, Liu, Mitchell, Gaede, Stewart, Laba, Joanna, Mulroy, Liam, Senthi, Sashendra, Louie, Alexander V, Swaminath, Anand, Chalmers, Anthony, Warner, Andrew, Slotman, Ben J, de Gruijl, Tanja D, Allan, Alison, Senan, Suresh

“…Stereotactic ablative radiotherapy (SABR) has emerged as a new treatment option for patients with oligometastatic disease. SABR delivers precise, high-dose,…”
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ClonoScreen3D – A Novel 3-Dimensional Clonogenic Screening Platform for Identification of Radiosensitizers for Glioblastoma by Jackson, Mark R., Richards, Amanda R., Oladipupo, Abdul-Basit Ayoola, Chahal, Sandeep K., Caragher, Seamus, Chalmers, Anthony J., Gomez-Roman, Natividad

“…Glioblastoma (GBM) is a lethal brain tumor. Standard-of-care treatment comprising surgery, radiation, and chemotherapy results in median survival rates of 12…”
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