Search Results - "Challis, G. L"

Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights by Masschelein, J, Jenner, M, Challis, G L

“…Covering: up to 2017The overwhelming majority of antibiotics in clinical use originate from Gram-positive Actinobacteria. In recent years, however,…”
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Coelichelin, a new peptide siderophore encoded by the Streptomyces coelicolor genome: structure prediction from the sequence of its non-ribosomal peptide synthetase by Challis, Gregory L., Ravel, Jacques

“…Abstract A gene cluster for the non-ribosomal synthesis of a peptide of unknown structure has been identified in the partial genome sequence of Streptomyces…”
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Structural changes in freshwater fish and chironomids exposed to bacterial exotoxins by Lewis, J.W., Morley, N.J., Ahmad, M., Challis, G.L., Wright, R., Bicker, R., Morritt, D.

“…Mass fish mortalities have been reported in the past decade from British waters, often coinciding with blooms of filamentous actinobacteria, particularly…”
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Thioester reduction and aldehyde transamination are universal steps in actinobacterial polyketide alkaloid biosynthesis by Awodi, U R, Ronan, J L, Masschelein, J, de Los Santos, E L C, Challis, G L

“…Actinobacteria produce a variety of polyketide alkaloids with unusual structures. Recently, it was shown that a type I modular polyketide synthase (PKS) is…”
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PCR-Targeted Streptomyces Gene Replacement Identifies a Protein Domain Needed for Biosynthesis of the Sesquiterpene Soil Odor Geosmin by Gust, Bertolt, Challis, Greg L., Fowler, Kay, Kieser, Tobias, Chater, Keith F.

“…Streptomycetes are high G+C Gram-positive, antibiotic-producing, mycelial soil bacteria. The 8.7-Mb Streptomyces coelicolor genome was previously sequenced by…”
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Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2) by Bentley, S. D, Hopwood, D. A, Chater, K. F, Cerdeño-Tárraga, A.-M, Challis, G. L, Thomson, N. R, James, K. D, Harris, D. E, Quail, M. A, Kieser, H, Harper, D, Bateman, A, Brown, S, Chandra, G, Chen, C. W, Collins, M, Cronin, A, Fraser, A, Goble, A, Hidalgo, J, Hornsby, T, Howarth, S, Huang, C.-H, Kieser, T, Larke, L, Murphy, L, Oliver, K, O'Neil, S, Rabbinowitsch, E, Rajandream, M.-A, Rutherford, K, Rutter, S, Seeger, K, Saunders, D, Sharp, S, Squares, R, Squares, S, Taylor, K, Warren, T, Wietzorrek, A, Woodward, J, Barrell, B. G, Parkhill, J

“…Streptomyces coelicolor is a representative of the group of soil-dwelling, filamentous bacteria responsible for producing most natural antibiotics used in…”
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Identification of a Cluster of Genes that Directs Desferrioxamine Biosynthesis in Streptomyces coelicolor M145 by BARONA-GóMEZ, Francisco, WONG, Ursula, GIANNAKOPULOS, Anastassios E., DERRICK, Peter J., CHALLIS, Gregory L.

“…Desferrioxamines are a structurally related family of tris-hydroxamate siderophores that form strong hexadentate complexes with ferric iron. Desferrioxamine B…”
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Substrate recognition by nonribosomal peptide synthetase multi-enzymes by Lautru, Sylvie, Challis, Gregory L

“…Department of Chemistry, The University of Warwick, Coventry CV4 7AL, UK Correspondence Sylvie Lautru S.Lautru{at}warwick.ac.uk Nonribosomal peptide…”
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The vbs genes that direct synthesis of the siderophore vicibactin in Rhizobium leguminosarum: their expression in other genera requires ECF σ factor RpoI by Carter, R. A., Worsley, P. S., Sawers, G., Challis, G. L., Dilworth, M. J., Carson, K. C., Lawrence, J. A., Wexler, M., Johnston, A. W. B., Yeoman, K. H.

“…Summary A cluster of eight genes, vbsGSO, vbsADL, vbsC and vbsP, are involved in the synthesis of vicibactin, a cyclic, trihydroxamate siderophore made by the…”
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Analysis of the prodiginine biosynthesis gene cluster of Streptomyces coelicolor A3(2): new mechanisms for chain initiation and termination in modular multienzymes by Cerdeño, Ana M., Bibb, Mervyn J., Challis, Gregory L.

“…Background: Prodiginines are a large family of pigmented oligopyrrole antibiotics with medicinal potential as immunosuppressants and antitumour agents that are…”
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Mechanisms for incorporation of glycerol-derived precursors into polyketide metabolites by WALTON, Laura J, CORRE, Christophe, CHALLIS, Gregory L

“…Several polyketide secondary metabolites are shown by feeding experiments to incorporate glycerol-derived 3-carbon starter units, 2-carbon extender units, or…”
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Thioester reduction and aldehyde transamination are universal steps in actinobacterial polyketide alkaloid biosynthesisElectronic supplementary information (ESI) available: Experimental procedures and additional tables, figures, chromatograms and results from biological assays. See DOI: 10.1039/c6sc02803a by Awodi, U. R, Ronan, J. L, Masschelein, J, de los Santos, E. L. C, Challis, G. L

“…Actinobacteria produce a variety of polyketide alkaloids with unusual structures. Recently, it was shown that a type I modular polyketide synthase (PKS) is…”
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Thioester reduction and aldehyde transamination are universal steps in actinobacterial polyketide alkaloid biosynthesis† †Electronic supplementary information (ESI) available: Experimental procedures and additional tables, figures, chromatograms and results from biological assays. See DOI: 10.1039/c6sc02803a Click here for additional data file by Awodi, U. R., Ronan, J. L., Masschelein, J., de los Santos, E. L. C., Challis, G. L.

“…Polyketide synthase reductive chain release and subsequent transamination are key steps in the biosynthesis of polyketide alkaloids in actinobacteria…”
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Type III Polyketide Synthase β-Ketoacyl-ACP Starter Unit and Ethylmalonyl-CoA Extender Unit Selectivity Discovered by Streptomyces coelicolor Genome Mining by Song, Lijiang, Barona-Gomez, Francisco, Corre, Christophe, Xiang, Longkuan, Udwary, Daniel W, Austin, Michael B, Noel, Joseph P, Moore, Bradley S, Challis, Gregory L

“…Polyketide synthases (PKSs) are involved in the biosynthesis of many important natural products. In bacteria, type III PKSs typically catalyze iterative…”
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Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains by Challis, Gregory L, Ravel, Jacques, Townsend, Craig A

“…Background: Nonribosomal peptide synthetases (NRPSs) are large modular proteins that selectively bind, activate and condense amino acids in an ordered manner…”
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Widely Distributed Bacterial Pathway for Siderophore Biosynthesis Independent of Nonribosomal Peptide Synthetases by Challis, Gregory L

“…Catch Fe if you can. Many siderophores are peptides biosynthesised by the well‐studied nonribosomal peptide synthetase (NRPS) multienzyme family. However,…”
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Synergy and Contingency as Driving Forces for the Evolution of Multiple Secondary Metabolite Production by Streptomyces Species by Challis, Gregory L., Hopwood, David A.

“…In this article we briefly review theories about the ecological roles of microbial secondary metabolites and discuss the prevalence of multiple secondary…”
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Discovery of a new peptide natural product by Streptomyces coelicolor genome mining by Challis, Gregory L, Lautru, Sylvie, Deeth, Robert J, Bailey, Lianne M

“…Analyses of microbial genome sequences reveal numerous examples of gene clusters encoding proteins typically involved in complex natural product biosynthesis…”
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Genomic Plasticity of the Causative Agent of Melioidosis, Burkholderia pseudomallei by Matthew T. G. Holden, Titball, Richard W., Peacock, Sharon J., Cerdeño-Tárraga, Ana M., Atkins, Timothy, Crossman, Lisa C., Pitt, Tyrone, Churcher, Carol, Mungall, Karen, Bentley, Stephen D., Sebaihia, Mohammed, Thomson, Nicholas R., Bason, Nathalie, Beacham, Ifor R., Brooks, Karen, Brown, Katherine A., Brown, Nat F., Challis, Greg L., Cherevach, Inna, Chillingworth, Tracy, Cronin, Ann, Crossett, Ben, Davis, Paul, DeShazer, David, Feltwell, Theresa, Fraser, Audrey, Hance, Zahra, Hauser, Heidi, Holroyd, Simon, Jagels, Kay, Keith, Karen E., Maddison, Mark, Moule, Sharon, Price, Claire, Quail, Michael A., Rabbinowitsch, Ester, Rutherford, Kim, Sanders, Mandy, Simmonds, Mark, Songsivilai, Sirirurg, Stevens, Kim, Tumapa, Sarinna, Vesaratchavest, Monkgol, Whitehead, Sally, Yeats, Corin, Barrell, Bart G., Petra C. F. Oyston, Parkhill, Julian, Greenberg, E. Peter

“…Burkholderia pseudomallei is a recognized biothreat agent and the causative agent of melioidosis. This Gram-negative bacterium exists as a soil saprophyte in…”
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Structural aspects of non-ribosomal peptide biosynthesis by Challis, Gregory L, Naismith, James H

“…Small peptides have powerful biological activities ranging from antibiotic to immune suppression. These peptides are synthesized by non-ribosomal peptide…”
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