Search Results - "Challis"

Systemic AAV vectors for widespread and targeted gene delivery in rodents by Challis, Rosemary C., Ravindra Kumar, Sripriya, Chan, Ken Y., Challis, Collin, Beadle, Keith, Jang, Min J., Kim, Hyun Min, Rajendran, Pradeep S., Tompkins, John D., Shivkumar, Kalyanam, Deverman, Benjamin E., Gradinaru, Viviana

“…We recently developed adeno-associated virus (AAV) capsids to facilitate efficient and noninvasive gene transfer to the central and peripheral nervous systems…”
Get full text

Discovery of microbial natural products by activation of silent biosynthetic gene clusters by Rutledge, Peter J., Challis, Gregory L.

“…Key Points Microorganisms produce an array of specialized metabolites with a wide range of biological activities and potential applications, such as…”
Get full text

Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice by Challis, Collin, Hori, Acacia, Sampson, Timothy R., Yoo, Bryan B., Challis, Rosemary C., Hamilton, Adam M., Mazmanian, Sarkis K., Volpicelli-Daley, Laura A., Gradinaru, Viviana

“…Parkinson’s disease is a synucleinopathy that is characterized by motor dysfunction, death of midbrain dopaminergic neurons and accumulation of α-synuclein…”
Get full text

Neuroendocrine Mechanisms in Pregnancy and Parturition by Petraglia, Felice, Imperatore, Alberto, Challis, John R. G

“…The complex mechanisms controlling human parturition involves mother, fetus, and placenta, and stress is a key element activating a series of physiological…”
Get full text

Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights by Masschelein, J, Jenner, M, Challis, G L

“…Covering: up to 2017The overwhelming majority of antibiotics in clinical use originate from Gram-positive Actinobacteria. In recent years, however,…”
Get more information

A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice by Sampson, Timothy R, Challis, Collin, Jain, Neha, Moiseyenko, Anastasiya, Ladinsky, Mark S, Shastri, Gauri G, Thron, Taren, Needham, Brittany D, Horvath, Istvan, Debelius, Justine W, Janssen, Stefan, Knight, Rob, Wittung-Stafshede, Pernilla, Gradinaru, Viviana, Chapman, Matthew, Mazmanian, Sarkis K

“…Amyloids are a class of protein with unique self-aggregation properties, and their aberrant accumulation can lead to cellular dysfunctions associated with…”
Get full text

Foot arch rigidity in walking: In vivo evidence for the contribution of metatarsophalangeal joint dorsiflexion by Davis, Daniel J, Challis, John H

“…Human foot rigidity is thought to provide a more effective lever with which to push against the ground. Tension of the plantar aponeurosis (PA) with increased…”
Get full text

BlobToolKit - Interactive Quality Assessment of Genome Assemblies by Challis, Richard, Richards, Edward, Rajan, Jeena, Cochrane, Guy, Blaxter, Mark

“…Reconstruction of target genomes from sequence data produced by instruments that are agnostic as to the species-of-origin may be confounded by contaminant DNA…”
Get full text

Effect of Oral Probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 on the Vaginal Microbiota, Cytokines and Chemokines in Pregnant Women by Yang, Siwen, Reid, Gregor, Challis, John R G, Gloor, Gregory B, Asztalos, Elizabeth, Money, Deborah, Seney, Shannon, Bocking, Alan D

“…Spontaneous preterm birth is associated with vaginal microbial dysbiosis. As certain strains of lactobacilli help restore homeostasis in non-pregnant women,…”
Get full text

Mining microbial genomes for new natural products and biosynthetic pathways by Challis, Gregory L

“…Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK Correspondence Gregory L. Challis G.L.Challis{at}warwick.ac.uk Analyses of microbial…”
Get full text

Microplastic contamination in Lake Winnipeg, Canada by Anderson, Philip J., Warrack, Sarah, Langen, Victoria, Challis, Jonathan K., Hanson, Mark L., Rennie, Michael D.

“…Microplastics are an emerging contaminant of concern in aquatic ecosystems. To better understand microplastic contamination in North American surface waters,…”
Get full text

Marker Set Configuration and Rigid Body Attitude Determination by Challis, John H

“…Image-based motion-analysis systems typically place markers on the bodies of interest. The error in determining segment attitude from these markers is a…”
Get more information

Genome Mining for Novel Natural Product Discovery by Challis, Gregory L

Get full text

Exploitation of the Streptomyces coelicolor A3(2) genome sequence for discovery of new natural products and biosynthetic pathways by Challis, Gregory L

“…Streptomyces, and related genera of Actinobacteria, are renowned for their ability to produce antibiotics and other bioactive natural products with a wide…”
Get full text

Mechanism and Catalytic Diversity of Rieske Non-Heme Iron-Dependent Oxygenases by Barry, Sarah M, Challis, Gregory L

“…Rieske non-heme iron-dependent oxygenases are important enzymes that catalyze a wide variety of reactions in the biodegradation of xenobiotics and biosynthesis…”
Get full text

Expression of Natural Antimicrobials by Human Placenta and Fetal Membranes by King, A.E, Paltoo, A, Kelly, R.W, Sallenave, J.-M, Bocking, A.D, Challis, J.R.G

“…Abstract Preterm birth associated with infection is a major clinical problem. We hypothesized that this condition is associated with altered expression of…”
Get full text

Examination of the ill-conditioning of the inertia matrix used in mechanical analyses by Challis, John H.

“…In a state-space representation of the equations of motion for a system of rigid bodies one component of these equations is the so-called inertia matrix. This…”
Get full text

Strategies for the Discovery of New Natural Products by Genome Mining by Zerikly, Malek, Challis, Gregory L

“…New drugs from silent gene clusters: Analysis of genome sequence data has identified numerous "cryptic" gene clusters encoding novel natural product…”
Get full text

PCR-Targeted Streptomyces Gene Replacement Identifies a Protein Domain Needed for Biosynthesis of the Sesquiterpene Soil Odor Geosmin by Gust, Bertolt, Challis, Greg L., Fowler, Kay, Kieser, Tobias, Chater, Keith F.

“…Streptomycetes are high G+C Gram-positive, antibiotic-producing, mycelial soil bacteria. The 8.7-Mb Streptomyces coelicolor genome was previously sequenced by…”
Get full text

A discrete level-set topology optimization code written in Matlab by Challis, Vivien J.

“…This paper presents a compact Matlab implementation of the level-set method for topology optimization. The code can be used to minimize the compliance of a…”
Get full text