Search Results - "Challacombe, S.J"

Clinical assessment of oral dryness: development of a scoring system related to salivary flow and mucosal wetness by Osailan, S.M., PhD, MFDSRCSeng, MSc, BDS, Pramanik, R., BSc, Shirlaw, P, Proctor, G.B., BSc, PhD, Challacombe, S.J

“…Objective The aim of this study was to develop a clinical oral dryness score (CODS) for routine use in assessment of xerostomia patients and determine its…”
Get full text

An Oral Disease Severity Score validated for use in oral pemphigus vulgaris by Ormond, M., McParland, H., Donaldson, A.N.A., Andiappan, M., Cook, R.J., Escudier, M., Hullah, E., Higham, J., McMillan, R., Taylor, J., Shirlaw, P.J., Challacombe, S.J., Setterfield, J.F.

“…Summary Background Pemphigus vulgaris (PV) is a rare autoimmune bullous disease, which can present with recalcitrant oral mucosal lesions. Optimal management…”
Get full text

Serum and salivary IgG and IgA antibodies to desmoglein 3 in mucosal pemphigus vulgaris by Ali, S., Kelly, C., Challacombe, S.J., Donaldson, A.N.A., Bhogal, B.S., Setterfield, J.F.

“…Summary Background The use of saliva for the diagnosis of pemphigus vulgaris (PV) by enzyme‐linked immunosorbent assay (ELISA) using desmoglein (Dsg)3 antigen…”
Get full text

Efficacy of mycophenolate mofetil in severe mucocutaneous lichen planus: a retrospective review of 10 patients by Wee, J.S., Shirlaw, P.J., Challacombe, S.J., Setterfield, J.F.

“…Summary Background  Ulcerative lichen planus is an uncommon and severe subtype of lichen planus primarily affecting the oral mucosal surfaces. It may be…”
Get full text

DNA ploidy in proliferative verrucous leukoplakia by Klanrit, P, Sperandio, M, Brown, A.L, Shirlaw, P.J, Challacombe, S.J, Morgan, P.R, Odell, E.W

“…Summary Proliferative verrucous leukoplakia (PVL) is a clinicopathologically distinctive form of oral leukoplakia presenting with multifocal flat, nodular and…”
Get full text

Bullous pemphigoid antigen II (BP180) and its soluble extracellular domains are major autoantigens in mucous membrane pemphigoid: the pathogenic relevance to HLA class II alleles and disease severity by Oyama, N., Setterfield, J.F., Powell, A.M., Sakuma-Oyama, Y., Albert, S., Bhogal, B.S., Vaughan, R.W., Kaneko, F., Challacombe, S.J., Black, M.M.

“…Summary Background  Mucous membrane pemphigoid (MMP), a chronic autoimmune subepithelial blistering disease, is associated with circulating IgG and/or IgA…”
Get full text

Epithelioid Haemangioendothelioma of the mandibular gingiva: case report and literature review by Ali, Shabnum, Odell, E.W, Whaites, E, Robinson, P.D, Challacombe, S.J

“…Highlights • This paper demonstrates that oral EHE is an unpredictable lesion that seems to behave in a relatively benign fashion. This is in contrast with…”
Get full text

The severity of cutaneous and oral pemphigus is related to desmoglein 1 and 3 antibody levels by Harman, K.E., Seed, P.T., Gratian, M.J., Bhogal, B.S., Challacombe, S.J., Black, M.M.

“…Background Pemphigus vulgaris (PV) and foliaceus (PF) are characterized by antibodies to the desmosomal proteins desmoglein 3 (Dsg3) and desmoglein 1 (Dsg1),…”
Get full text

An Appreciation of a Giant in Orofacial Sciences Research—John Greenspan by Challacombe, S.J., Klein, O.D.

“…Professor John S. Greenspan died on March 31, 2023. He was a renowned and accomplished academic, dentist/scientist, pathologist, and administrator who made…”
Get full text

Ecological study of Streptococcus mutans, Streptococcus sobrinus and Lactobacillus spp. at sub-sites from approximal dental plaque from children by Babaahmady, K G, Challacombe, S J, Marsh, P D, Newman, H N

“…Previous immunofluorescence (IF) studies have indicated that Streptococcus mutans may preferentially colonise specific sub-sites within approximal plaque. The…”
Get more information

The influence of denture-wearing and age on the oral microflora by Marsh, P D, Percival, R S, Challacombe, S J

“…The effects of denture-wearing and age on the prevalence of selected bacteria of dental significance and on the carriage of opportunistic pathogens in molar…”
Get more information

Validation of an Oral Disease Severity Score (ODSS) tool for use in oral mucous membrane pemphigoid by Ormond, M., McParland, H., Thakrar, P., Donaldson, A.N.A., Andiappan, M., Cook, R.J., Escudier, M.E., Higham, J., Hullah, E., McMillan, R., Taylor, J., Shirlaw, P.J., Challacombe, S.J., Setterfield, J.F.

“…Summary Background Mucous membrane pemphigoid (MMP) is a rare autoimmune bullous disease predominantly affecting the oral mucosa. Optimal management relies…”
Get full text

寻常天疱疮口腔疾病严重程度评分 by Ormond, M., McParland, H., Donaldson, A.N.A., Andiappan, M., Cook, R.J., Escudier, M., Hullah, E., Higham, J., McMillan, R., Taylor, J., Shirlaw, P.J., Challacombe, S.J., Setterfield, J.F.

“…Summary 寻常天胞疮 (Pemphigus vulgaris, PV) 是一种罕见且通常严重的自身免疫性疾病,可在许多部位引起疼痛性水疱,包括皮肤、口腔、鼻腔、咽喉或生殖器。它通过产生针对皮肤或粘膜的有害抗体来做到这一点。口腔通常是该疾病开始的部位,并且可能持续多年受影响。免疫抑制药物可用于治疗 PV,…”
Get full text

Distribution and isolation frequency of eight streptococcal species in saliva from predentate and dentate children and adults by Tappuni, A R, Challacombe, S J

“…The isolation frequency and distribution of eight recently defined streptococcal species have been investigated in the saliva of adults and that of both…”
Get more information

Introduction by Coogan, M.M., Challacombe, S.J.

Get full text

Introduction by Coogan, M.M., Challacombe, S.J.

Get full text

Introduction by Coogan, M.M., Challacombe, S.J.

Get full text

Salivary IgA and IgG antibodies to bullous pemphigoid 180 noncollagenous domain 16a as diagnostic biomarkers in mucous membrane pemphigoid by Ali, S., Kelly, C., Challacombe, S.J., Donaldson, A.N.A., Dart, J.K.G., Gleeson, M., Setterfield, J.F.

“…Summary Background Mucous membrane pemphigoid (MMP) is an uncommon mucocutaneous immunobullous disorder. Use of saliva for diagnosis by enzyme‐linked…”
Get full text

Professor Thomas Lehner: Archetypal Translational Scientist by Challacombe, S.J.

“…Professor Thomas Lehner is one of the most distinguished oral and dental researchers to have come out of the UK. Over the past 40 years, he has made an…”
Get full text

Is the Oral Disease Severity Score going to be useful for dermatologists when assessing pemphigus? Reply from the authors by Setterfield, J.F., Ormond, M., Donaldson, A.N.A., Challacombe, S.J.

“…Linked Articles: Murrell et al. Br J Dermatol 2018; 179:816‐817. Ormond et al. Br J Dermatol 2018; 179:872–881…”
Get full text