Search Results - "Challa, Anita"

Minimal cross-linking and epitope requirements for CD40-dependent suppression of apoptosis contrast with those for promotion of the cell cycle and homotypic adhesions in human B cells by Pound, J D, Challa, A, Holder, M J, Armitage, R J, Dower, S K, Fanslow, W C, Kikutani, H, Paulie, S, Gregory, C D, Gordon, J

“…Eight different CD40 mAb shared with soluble trimeric CD40 ligand (sCD40LT) the capacity to rescue germinal center (GC) B cells from spontaneous apoptosis and…”
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The serotonin transporter (SLC6A4) is present in B-cell clones of diverse malignant origin: probing a potential anti-tumor target for psychotropics by Meredith, Elizabeth J, Holder, Michelle J, Chamba, Anita, Challa, Anita, Drake-Lee, Adrian, Bunce, Christopher M, Drayson, Mark T, Pilkington, Geoffrey, Blakely, Randy D, Dyer, Martin J S, Barnes, Nicholas M, Gordon, John

“…Following our previous description of the serotonin transporter (SERT) acting as a conduit to 5-hydroxytryptamine (5-HT)-mediated apoptosis, specifically in…”
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The serotonin transporter (SLC6A4) is present in B‐cell clones of diverse malignant origin: probing a potential antitumor target for psychotropics by Meredith, Elizabeth J., Holder, Michelle J., Chamba, Anita, Challa, Anita, Lee, Adrian Drake, Bunce, Christopher M., Drayson, Mark T., Pilkington, Geoffrey, Blakely, Randy D., Dyer, Martin J. S., Barnes, Nicholas M., Gordon, John

“…ABSTRACTFollowing our previous description of the serotonin transporter (SERT) acting as a conduit to 5‐hydroxytryptamine (5‐HT)‐mediated apoptosis,…”
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Enhancing the anti-lymphoma potential of 3,4-methylenedioxymethamphetamine (‘ecstasy’) through iterative chemical redesign: mechanisms and pathways to cell death by Wasik, Agata M., Gandy, Michael N., McIldowie, Matthew, Holder, Michelle J., Chamba, Anita, Challa, Anita, Lewis, Katie D., Young, Stephen P., Scheel-Toellner, Dagmar, Dyer, Martin J., Barnes, Nicholas M., Piggott, Matthew J., Gordon, John

“…Summary While 3,4-methylenedioxymethamphetamine (MDMA/‘ecstasy’) is cytostatic towards lymphoma cells in vitro, the concentrations required militate against…”
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CD154 Tone Sets the Signaling Pathways and Transcriptome Generated in Model CD40-Pluricompetent L3055 Burkitt's Lymphoma Cells by Stewart, Ross, Wei, Wenbin, Challa, Anita, Armitage, Richard J, Arrand, John R, Rowe, Martin, Young, Lawrence S, Eliopoulos, Aristides, Gordon, John

“…Activated B cells reacting to small amounts of CD40L (CD154) maintain homeostasis by suppressing default apoptosis. Additional outcomes, particularly…”
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Dynamic interplay between the neutral glycosphingolipid CD77/Gb3 and the therapeutic antibody target CD20 within the lipid bilayer of model B lymphoma cells by Jarvis, Rosemary M, Chamba, Anita, Holder, Michelle J, Challa, Anita, Smith, Daniel C, Hodgkin, Matthew N, Lord, J Michael, Gordon, John

“…The centroblast-specific differentiation marker CD77 (Gb(3)), is the receptor for Shiga-like toxin (SLT). The dynamic relationship between Gb(3)/CD77 and key…”
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Dynamic interplay between the neutral glycosphingolipid CD77/Gb 3 and the therapeutic antibody target CD20 within the lipid bilayer of model B lymphoma cells by Jarvis, Rosemary M., Chamba, Anita, Holder, Michelle J., Challa, Anita, Smith, Daniel C., Hodgkin, Matthew N., Lord, J. Michael, Gordon, John

“…The centroblast-specific differentiation marker CD77 (Gb 3), is the receptor for Shiga-like toxin (SLT). The dynamic relationship between Gb 3/CD77 and key…”
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CD40 ligation downregulates EBNA‐2 and LMP‐1 expression in EBV‐transformed lymphoblastoid cell lines by Pokrovskaja, Katja, Ehlin‐Henriksson, Barbro, Kiss, Csaba, Challa, Anita, Gordon, John, Gogolak, Peter, Klein, George, Szekely, Laszlo

“…Epstein‐Barr virus (EBV) drives the proliferation of human B cells in vitro and during primary infection in vivo. The transformed immunoblasts express nuclear…”
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Population depletion activates autonomous CD154-dependent survival in biopsylike Burkitt lymphoma cells by Challa, Anita, Eliopoulos, Aristides G., Holder, Michelle J., Burguete, Alondra Schweizer, Pound, John D., Chamba, Anita, Grafton, Gillian, Armitage, Richard J., Gregory, Christopher D., Martinez-Valdez, Hector, Young, Lawrence, Gordon, John

“…Population size is governed through cells reacting to a variety of intrinsic and extrinsic cues. Tumors, while liberated from many of the homeostatic…”
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Release of clonal block in B cell chronic lymphocytic leukaemia by engagement of co-operative epitopes on CD40 by Jacob, Abraham, Pound, John D., Challa, Anita, Gordon, John

“…The clonal cells of patients with B-chronic lymphocytic leukaemia (B-CLL)—which essentially reside in a resting configuration—are characterised by a relative…”
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