Search Results - "Chalikian, Tigran V."

Heat capacity changes associated with G-quadruplex unfolding by Garabet, Arees, Liu, Lutan, Chalikian, Tigran V

“…G-quadruplexes are four-stranded DNA structures that have been found in the cell and are thought to act as elements of control in genomic events. The…”
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Effect of cosolvent on protein stability: a theoretical investigation by Chalikian, Tigran V

“…We developed a statistical thermodynamic algorithm for analyzing solvent-induced folding/unfolding transitions of proteins. The energetics of protein…”
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On urea and temperature dependences of m-values by Amsdr, Alah, Noudeh, Negar Dehghan, Liu, Lutan, Chalikian, Tigran V

“…The denaturing or stabilizing influence of a cosolvent on a protein structure is governed by a fine balance of the energetics of the excluded volume effect and…”
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Stabilization of G-Quadruplex-Duplex Hybrid Structures Induced by Minor Groove-Binding Drugs by Scott, Lily, Chalikian, Tigran V

“…Once it had been realized that G-quadruplexes exist in the cell and are involved in regulation of genomic processes, the quest for ligands recognizing these…”
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Hydration Changes Accompanying Helix-to-Coil DNA Transitions by Son, Ikbae, Shek, Yuen Lai, Dubins, David N, Chalikian, Tigran V

“…We applied ultrasonic velocimetric and high-precision densimetric measurements to characterizing the helix-to-coil transition of the GGCATTACGG/CCGTAATGCC…”
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Volumetric measurements in binary solvents: Theory to experiment by Chalikian, Tigran V.

“…Interactions of proteins and protein groups with water-soluble cosolvents have been studied for the last 50 years with a variety of theoretical and…”
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Tribute to Kenneth J. Breslauer by Chalikian, Tigran V.

“…It is an exciting experience to serve as guest editor for a Special Issue celebrating the 75th birthday of Professor Kenneth J [...]…”
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Volumetric Interplay between the Conformational States Adopted by Guanine-Rich DNA from the c‑MYC Promoter by Liu, Lutan, Scott, Lily, Tariq, Nabeel, Kume, Takuma, Dubins, David N, Macgregor, Robert B, Chalikian, Tigran V

“…The kinetic and thermodynamic stabilities of G-quadruplex structures have been extensively studied. In contrast, systematic investigations of the volumetric…”
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Effects of Salt on the Stability of a G‑Quadruplex from the Human c‑MYC Promoter by Kim, Byul G, Evans, Heather M, Dubins, David N, Chalikian, Tigran V

“…In an atmosphere of potassium ions, a modified c-MYC NHE III1 sequence with two G-to-T mutations (MYC22-G14T/G23T) forms a highly stable parallel-stranded…”
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Ionic Effects on VEGF G‑Quadruplex Stability by Kim, Byul G, Long, Ji, Dubins, David N, Chalikian, Tigran V

“…In a potassium solution, a modified 22-meric DNA sequence Pu22-T12T13 from a region proximal to the transcription initiation site of the human VEGF gene adopts…”
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Probing the Ionic Atmosphere and Hydration of the c‑MYC i‑Motif by Liu, Lutan, Kim, Byul G, Feroze, Ujala, Macgregor, Robert B, Chalikian, Tigran V

“…G-quadruplexes and i-motifs are noncanonical secondary structures of DNA that appear to play a number of regulatory roles in the genome with clear connection…”
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Volumetric Properties of Four-Stranded DNA Structures by Chalikian, Tigran V., Macgregor, Robert B.

“…Four-stranded non-canonical DNA structures including G-quadruplexes and i-motifs have been found in the genome and are thought to be involved in regulation of…”
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Volumetric Characterization of Sodium-Induced G-Quadruplex Formation by Fan, Helen Y, Shek, Yuen Lai, Amiri, Amir, Dubins, David N, Heerklotz, Heiko, Macgregor, Robert B, Chalikian, Tigran V

“…Oligodeoxyribonucleotides (ODN) with repeats of the human telomeric sequence can adopt different tetrahelical conformations that exhibit similar energetic…”
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Parsing Partial Molar Volumes of Small Molecules: A Molecular Dynamics Study by Patel, Nisha, Dubins, David N, Pomès, Régis, Chalikian, Tigran V

“…We used molecular dynamics (MD) simulations in conjunction with the Kirkwood−Buff theory to compute the partial molar volumes for a number of small solutes of…”
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Stability of DNA Duplexes Containing GG, CC, AA, and TT Mismatches by Tikhomirova, Anna, Beletskaya, Irina V, Chalikian, Tigran V

“…We employed salt-dependent differential scanning calorimetric measurements to characterize the stability of six oligomeric DNA duplexes…”
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G‑Quadruplex Recognition by Tetraalkylammonium Ions: A New Paradigm for Discrimination between Parallel and Antiparallel G‑Quadruplexes by Li, Xuan, Dubins, David N., Völker, Jens, Chalikian, Tigran V.

“…G-quadruplexes are an important class of noncanonical secondary structures of DNA that exist in the cell and are involved in the regulation of principal…”
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Conformational preferences of DNA from the promoter regions of the c-MYC, VEGF, and Bcl-2 oncogenes by Liu, Lutan, Wells, James W., Chalikian, Tigran V.

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Effects of buffer ionization in protein transition volumes by Lee, Soyoung, Heerklotz, Heiko, Chalikian, Tigran V.

“…Protein denaturation events are generally associated with a change in the state of ionization of abnormally titrating groups and, therefore, are coupled with…”
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Excluded volume contribution to cosolvent-mediated modulation of macromolecular folding and binding reactions by Chalikian, Tigran V.

“…Water-miscible cosolvents may stabilize or destabilize proteins, nucleic acids, and their complexes or may exert no influence. The mode of action of a specific…”
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A More Unified Picture for the Thermodynamics of Nucleic Acid Duplex Melting: A Characterization by Calorimetric and Volumetric Techniques by Chalikian, Tigran V., Völker, Jens, Plum, G. Eric, Breslauer, Kenneth J.

“…We use a combination of calorimetric and volumetric techniques to detect and to characterize the thermodynamic changes that accompany helix-to-coil transitions…”
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