Search Results - "Chalif, Joshua I"

Converging Mechanisms of p53 Activation Drive Motor Neuron Degeneration in Spinal Muscular Atrophy by Simon, Christian M., Dai, Ya, Van Alstyne, Meaghan, Koutsioumpa, Charalampia, Pagiazitis, John G., Chalif, Joshua I., Wang, Xiaojian, Rabinowitz, Joseph E., Henderson, Christopher E., Pellizzoni, Livio, Mentis, George Z.

“…The hallmark of spinal muscular atrophy (SMA), an inherited disease caused by ubiquitous deficiency in the SMN protein, is the selective degeneration…”
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Elucidating the neuroimmunology of traumatic brain injury: methodological approaches to unravel intercellular communication and function by Abou-El-Hassan, Hadi, Bernstock, Joshua D, Chalif, Joshua I, Yahya, Taha, Rezende, Rafael M, Weiner, Howard L, Izzy, Saef

“…The neuroimmunology of traumatic brain injury (TBI) has recently gained recognition as a crucial element in the secondary pathophysiological consequences that…”
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Spontaneous intramedullary abscesses caused by Streptococcus anginosus: two case reports and review of the literature by Cerecedo-Lopez, Christian D, Bernstock, Joshua D, Dmytriw, Adam A, Chen, Jason A, Chalif, Joshua I, Gupta, Saksham, Driver, Joseph, Huang, Kevin, Stanley, Susan E, Li, Jonathan Z, Chi, John, Lu, Yi

“…Intramedullary abscesses are rare infections of the spinal cord. Intramedullary abscesses often have a complex presentation, making a high index of suspicion…”
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Treating the dead; how far ought medicine go to obtain transplantable organs? by Bernstock, Joshua D, Chalif, Joshua I, Jha, Rohan, Brown, Ashley, Essayed, Walid I, Caplan, Arthur, Peruzzi, Pierpaolo

“…Under what circumstances, is it ethical to perform tumor surgery on a brain-dead individual? The neurosurgeons at Brigham and Women's Hospital were recently…”
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Reduced sensory synaptic excitation impairs motor neuron function via Kv2.1 in spinal muscular atrophy by Fletcher, Emily V, Simon, Christian M, Pagiazitis, John G, Chalif, Joshua I, Vukojicic, Aleksandra, Drobac, Estelle, Wang, Xiaojian, Mentis, George Z

“…The authors show that in a mouse model of spinal muscular atrophy (SMA), there is a reduction in sensory synaptic drive that leads to motor neuron dysfunction…”
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Control of mammalian locomotion by ventral spinocerebellar tract neurons by Chalif, Joshua I., Martínez-Silva, María de Lourdes, Pagiazitis, John G., Murray, Andrew J., Mentis, George Z.

“…Locomotion is a complex behavior required for animal survival. Vertebrate locomotion depends on spinal interneurons termed the central pattern generator (CPG),…”
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Benign Natural Progression of Small Cavernous Carotid Aneurysms Suggests Limited Clinical Utility of Serial Longitudinal Follow-up by Jha, Rohan, Zhao, Maryann, Ghannam, Jack Y, Blitz, Sarah, Chalif, Joshua I, Altshuler, Marcelle, Du, Rose

“…Aneurysms in the cavernous segment of the internal carotid artery (ICA) often present in an indolent fashion with limited morbidity. However, their growth…”
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Evaluating the Need for Durotomy and Duraplasty in Adults Undergoing Suboccipital Craniectomy for Chiari Decompression: A Case Series Analysis of Radiographic and Clinical Outcomes by Jha, Rohan, Chalif, Joshua I, Lu, Yi

“…Background Suboccipital craniectomy (SOC) in conjunction with dura opening and duraplasty for posterior fossa decompression is an effective treatment for…”
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Analysis of 179 posterior communicating artery infundibular dilations demonstrating low risk for transformation to aneurysm or rupture and the usefulness of the “round defect” by Blitz, Sarah E., Gelman, Justin, Chalif, Joshua I., Altshuler, Marcelle S., Dmytriw, Adam A., Du, Rose

“…Outpouchings, particularly those originating from the posterior communicating artery off the internal carotid artery (Pcom-Ops), are often unable to be…”
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The Relationship Among Surgeon Experience, Complications, and Radiographic Outcomes in Spine Deformity Surgery: The Experience of a Junior Surgeon by Yearley, Alexander G., Chalif, Joshua I., Chalif, Eric J., Zaidi, Hasan A.

“…To examine complication rates and radiographic outcomes in patients undergoing surgery for adult spinal deformity (ASD) by a junior surgeon. A study was…”
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Defining the Post-Operative Progression of Degenerative Scoliosis: An Analysis of Cases without Instrument Failure by Jha, Rohan, Chalif, Joshua I., Yearley, Alexander G., Chalif, Eric, Zaidi, Hasan A.

“…•We identify how radiographic parameters can be expected to change following TLIF.•We create a reference for surgeons to aim for in correcting spinal deformity…”
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Subtype Diversification and Synaptic Specificity of Stem Cell-Derived Spinal Interneurons by Hoang, Phuong T., Chalif, Joshua I., Bikoff, Jay B., Jessell, Thomas M., Mentis, George Z., Wichterle, Hynek

“…Neuronal diversification is a fundamental step in the construction of functional neural circuits, but how neurons generated from single progenitor domains…”
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Comparing reactive versus empiric cerebrospinal fluid drainage strategies for spinal perfusion pressure optimization in patients with acute traumatic spinal cord injuries by Lavadi, Raj S., Johnson, Benjamin R., Chalif, Joshua I., Shanahan, Regan, Das, Ashtah, Hamilton, David K., Agarwal, Nitin, Fields, Daryl P.

“…•Spinal cord hypoperfusion undermines recovery following spinal cord injury.•Cord perfusion pressure is managed via reactive or empiric CSF drainage…”
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Spinal projecting neurons in rostral ventromedial medulla co-regulate motor and sympathetic tone by Zhang, Zicong, Su, Junfeng, Tang, Jing, Chung, Leeyup, Page, Jessica C, Winter, Carla C, Liu, Yuchu, Kegeles, Evgenii, Conti, Sara, Zhang, Yu, Biundo, Jason, Chalif, Joshua I, Hua, Charles Y, Yang, Zhiyun, Yao, Xue, Yang, Yang, Chen, Shuqiang, Schwab, Jan M, Wang, Kuan Hong, Chen, Chinfei, Prerau, Michael J, He, Zhigang

“…Many behaviors require the coordinated actions of somatic and autonomic functions. However, the underlying mechanisms remain elusive. By opto-stimulating…”
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Spinal Metastases from Colorectal Cancer at Mass General Brigham: A Twenty-Year Case Series With Literature Review by Yearley, Alexander G., McNulty, Jack J., Chalif, Eric J., Chalif, Joshua I., Lee, Suk Joon, Klinger, Neil V., Zaidi, Hasan A.

“…We present an institutional case series of patients treated for colorectal carcinoma (CRC) spinal metastases to investigate the outcomes between no treatment,…”
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Prevalence, risk factors, natural history, and prognostic significance of Modic changes in the cervical spine: a comprehensive systematic review and meta-analysis of 12,754 participants by Nezameslami, Ahmadreza, Kankam, Samuel Berchi, Mohammadi, Mohammad, Mohamadi, Mobin, Mohammadi, Aynaz, Lapevandani, Mahsa M., Roohollahi, Faramarz, Farahbahksh, Farzin, Khoshnevisan, Alireza, Chalif, Joshua I., Lu, Yi, Chi, John

“…Objective Modic changes (MCs) in the cervical spine are common, but remain an under-researched phenomenon, particularly regarding their prevalence, natural…”
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Time of day does not impact spinal serotonin levels in humans by Anand, Sharath Kumar, Lavadi, Raj S., Johnston, Benjamin R., Chalif, Joshua I., Scanlon, James M., Wang, Weiwen, Agarwal, Nitin, Hamilton, David K., Fields, Daryl P., Van't Land, Clinton W.

“…Spinal serotonin enables neuro‐motor recovery (i.e., plasticity) in patients with debilitating paralysis. While there exists time of day fluctuations in…”
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Presenting characteristics and clinical outcomes of idiopathic versus neurofibromatosis type 2–associated spinal meningiomas: a retrospective institutional experience by Nawabi, Noah L. A., Chalif, Joshua I., Renauld, Sophia, Mehta, Neel H., Jha, Rohan, Gerstl, Jakob V. E., Chalif, Eric, Gupta, Saksham, Chi, John H.

“…OBJECTIVE Spinal meningioma (SM) is a pathology with an estimated incidence of nearly 1000 diagnoses per year in the United States and presents in 20% of…”
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Challenges in Contemporary Spine Surgery: A Comprehensive Review of Surgical, Technological, and Patient-Specific Issues by Mensah, Emmanuel O, Chalif, Joshua I, Baker, Jessica G, Chalif, Eric, Biundo, Jason, Groff, Michael W

“…Spine surgery has significantly progressed due to innovations in surgical techniques, technology, and a deeper understanding of spinal pathology. However,…”
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Craniocervical dural arteriovenous fistula: Microsurgical clipping and technical nuances with ICG by Kappel, Ari D, Chen, Jason A, Chalif, Joshua I, Bass, David I, Torio, Erickson F, Feroze, Abdullah H, Patel, Nirav J

“…A 48-year-old male with progressive congestive myelopathy had a craniocvervical DAVF treated with surgical clipping using ICG to confirm solitary inflow…”
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