Search Results - "Chali, Farah"

Microglial phenotypes in the human epileptic temporal lobe by Morin-Brureau, Mélanie, Milior, Giampaolo, Royer, Juliette, Chali, Farah, LeDuigou, Caroline, Savary, Etienne, Blugeon, Corinne, Jourdren, Laurent, Akbar, David, Dupont, Sophie, Navarro, Vincent, Baulac, Michel, Bielle, Franck, Mathon, Bertrand, Clemenceau, Stéphane, Miles, Richard

“…Using transcriptomics, anatomical studies, imaging and ELISA, Morin-Brureau et al. examine microglia in patients with temporal lobe epilepsies. In highly…”
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CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer's disease by Djelti, Fathia, Braudeau, Jerome, Hudry, Eloise, Dhenain, Marc, Varin, Jennifer, Bièche, Ivan, Marquer, Catherine, Chali, Farah, Ayciriex, Sophie, Auzeil, Nicolas, Alves, Sandro, Langui, Dominique, Potier, Marie-Claude, Laprevote, Olivier, Vidaud, Michel, Duyckaerts, Charles, Miles, Richard, Aubourg, Patrick, Cartier, Nathalie

“…Abnormalities in neuronal cholesterol homeostasis have been suspected or observed in several neurodegenerative disorders including Alzheimer's disease,…”
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Spinal cord transection-induced allodynia in rats--behavioral, physiopathological and pharmacological characterization by M'Dahoma, Saïd, Bourgoin, Sylvie, Kayser, Valérie, Barthélémy, Sandrine, Chevarin, Caroline, Chali, Farah, Orsal, Didier, Hamon, Michel

“…In humans, spinal cord lesions induce not only major motor and neurovegetative deficits but also severe neuropathic pain which is mostly resistant to classical…”
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Shift from extracellular signal-regulated kinase to AKT/cAMP response element-binding protein pathway increases survival-motor-neuron expression in spinal-muscular-atrophy-like mice and patient cells by Branchu, Julien, Biondi, Olivier, Chali, Farah, Collin, Thibault, Leroy, Felix, Mamchaoui, Kamel, Makoukji, Joelle, Pariset, Claude, Lopes, Philippe, Massaad, Charbel, Chanoine, Christophe, Charbonnier, Frédéric

“…Spinal muscular atrophy (SMA), a recessive neurodegenerative disease, is characterized by the selective loss of spinal motor neurons. No available therapy…”
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Low-Intensity Running and High-Intensity Swimming Exercises Differentially Improve Energy Metabolism in Mice With Mild Spinal Muscular Atrophy by Houdebine, Léo, D’Amico, Domenico, Bastin, Jean, Chali, Farah, Desseille, Céline, Rumeau, Valentin, Soukkari, Judy, Oudot, Carole, Rouquet, Thaïs, Bariohay, Bruno, Roux, Julien, Sapaly, Delphine, Weill, Laure, Lopes, Philippe, Djouadi, Fatima, Bezier, Cynthia, Charbonnier, Frédéric, Biondi, Olivier

“…Spinal Muscular Atrophy (SMA), an autosomal recessive neurodegenerative disease characterized by the loss of spinal-cord motor-neurons, is caused by mutations…”
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deletion of the microtubule-associated STOP protein affects the serotonergic mouse brain network by Fournet, Vincent, Jany, Marion, Fabre, Véronique, Chali, Farah, Orsal, Didier, Schweitzer, Annie, Andrieux, Annie, Messanvi, Fany, Giros, Bruno, Hamon, Michel, Lanfumey, Laurence, Deloulme, Jean-Christophe, Martres, Marie-Pascale

“…J. Neurochem. (2010) 115, 1579-1594. ABSTRACT: The deletion of microtubule-associated protein stable tubule only polypeptide (STOP) leads to neuroanatomical,…”
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Distinct P2Y Receptors Mediate Extension and Retraction of Microglial Processes in Epileptic and Peritumoral Human Tissue by Milior, Giampaolo, Morin-Brureau, Mélanie, Chali, Farah, Le Duigou, Caroline, Savary, Etienne, Huberfeld, Gilles, Rouach, Nathalie, Pallud, Johan, Capelle, Laurent, Navarro, Vincent, Mathon, Bertrand, Clemenceau, Stéphane, Miles, Richard

“…Microglia exhibit multiple, phenotype-dependent motility patterns often triggered by purinergic stimuli. However, little data exist on motility of human…”
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Inhibiting cholesterol degradation induces neuronal sclerosis and epileptic activity in mouse hippocampus by Chali, Farah, Djelti, Fathia, Eugene, Emmanuel, Valderrama, Mario, Marquer, Catherine, Aubourg, Patrick, Duykaerts, Charles, Miles, Richard, Cartier, Nathalie, Navarro, Vincent

“…Elevations in neuronal cholesterol have been associated with several degenerative diseases. An enhanced excitability and synchronous firing in surviving…”
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Lipid markers and related transcripts during excitotoxic neurodegeneration in kainate‐treated mice by Chali, Farah, Milior, Giampaolo, Marty, Serge, Morin‐Brureau, Mélanie, Le Duigou, Caroline, Savary, Etienne, Blugeon, Corinne, Jourdren, Laurent, Miles, Richard

“…Lipid homeostasis is dysregulated in some neurodegenerative diseases and after brain injuries due to excess glutamate or lack of oxygen. However the kinetics…”
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Transcriptomics and Live Imaging to Define Functional Phenotypes of Microglia in Pathological Human Tissue by Milior, Giampaolo, Chali, Farah, Dos Santos, Tiffany, Royer, Juliette, Miles, Richard, Morin-Brureau, Mélanie

“…Human microglia, as those of rodents, may possess multiple functional phenotypes. Here we present protocols to determine elements of these microglial…”
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Cholesterol redistribution triggered by CYP46A1 gene therapy improves major hallmarks of Niemann-Pick type C disease but is not sufficient to halt neurodegeneration by Nunes, Maria João, Carvalho, Andreia Neves, Reis, Joana, Costa, Daniela, Moutinho, Miguel, Mateus, Joana, Mendes de Almeida, Rita, Brito, Sara, Risso, Daniela, Nunes, Sofia, Castro-Caldas, Margarida, Gama, Maria João, Rodrigues, Cecília M.P., Xapelli, Sara, Diógenes, Maria José, Cartier, Nathalie, Chali, Farah, Piguet, Françoise, Rodrigues, Elsa

“…Cholesterol 24-hydroxylase (CYP46A1) is an exclusively neuronal cytochrome P450 enzyme responsible for converting cholesterol into 24S-hydroxycholesterol,…”
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Imaging pathological activities of human brain tissue in organotypic culture by Le Duigou, Caroline, Savary, Etienne, Morin-Brureau, Mélanie, Gomez-Dominguez, Daniel, Sobczyk, André, Chali, Farah, Milior, Giampaolo, Kraus, Larissa, Meier, Jochen C., Kullmann, Dimitri M., Mathon, Bertrand, de la Prida, Liset Menendez, Dorfmuller, Georg, Pallud, Johan, Eugène, Emmanuel, Clemenceau, Stéphane, Miles, Richard

“…Organotypic cultures prepared from tissue of patients with neurological syndromes survived for 6–8 weeks in culture. A, tissue damage was limited to the first…”
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Long‐term exercise‐specific neuroprotection in spinal muscular atrophy‐like mice by Chali, Farah, Desseille, Céline, Houdebine, Léo, Benoit, Evelyne, Rouquet, Thaïs, Bariohay, Bruno, Lopes, Philippe, Branchu, Julien, Della Gaspera, Bruno, Pariset, Claude, Chanoine, Christophe, Charbonnier, Frédéric, Biondi, Olivier

“…Key points The real impact of physical exercise parameters, i.e. intensity, type of contraction and solicited energetic metabolism, on neuroprotection in the…”
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IGF-1R Reduction Triggers Neuroprotective Signaling Pathways in Spinal Muscular Atrophy Mice by Biondi, Olivier, Branchu, Julien, Ben Salah, Amina, Houdebine, Léo, Bertin, Lise, Chali, Farah, Desseille, Céline, Weill, Laure, Sanchez, Gabriel, Lancelin, Camille, Aïd, Saba, Lopes, Philippe, Pariset, Claude, Lécolle, Sylvie, Côté, Jocelyn, Holzenberger, Martin, Chanoine, Christophe, Massaad, Charbel, Charbonnier, Frédéric

“…Spinal muscular atrophy (SMA) is a neuromuscular disease characterized by the selective loss of spinal motor neurons due to the depletion of the survival of…”
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Long‐term exercise‐specific neuroprotection in spinal muscular atrophy‐like mice by Chali, Farah, Desseille, Céline, Houdebine, Léo, Benoit, Evelyne, Rouquet, Thaïs, Bariohay, Bruno, Lopes, Philippe, Branchu, Julien, Della Gaspera, Bruno, Pariset, Claude, Chanoine, Christophe, Charbonnier, Frédéric, Biondi, Olivier

“…Key points The real impact of physical exercise parameters, i.e. intensity, type of contraction and solicited energetic metabolism, on neuroprotection in the…”
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IGF-1 R Reduction Triggers Neuroprotective Signaling Pathways in Spinal Muscular Atrophy Mice by Biondi, Olivier, Branchu, Julien, Salah, Amina Ben, Houdebine, Leo, Beltin, Lise, Chali, Farah, Desseille, Celine, Weill, Laure, Sanchez, Gabriel, Lancelin, Camille

“…Spinal muscular atrophy (SMA) is a neuromuscular disease characterized by the selective loss of spinal motor neurons due to the depletion of the survival of…”
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Physical exercise reduces cardiac defects in type 2 spinal muscular atrophy‐like mice by Biondi, Olivier, Lopes, Philippe, Desseille, Céline, Branchu, Julien, Chali, Farah, Salah, Amina Ben, Pariset, Claude, Chanoine, Christophe, Charbonnier, Frédéric

“…Key points •  The present study provides evidence that the cardiomyopathy observed in spinal muscular atrophy (SMA) model mice is mainly due to intrinsic…”
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