Search Results - "Chakshusmathi, Ghadiyaram"

Comparative Immunogenicity of Bacterially Expressed Soluble Trimers and Nanoparticle Displayed Influenza Hemagglutinin Stem Immunogens by Kar, Uddipan, Khaleeq, Sara, Garg, Priyanka, Bhat, Madhuraj, Reddy, Poorvi, Vignesh, Venkada Subramanian, Upadhyaya, Aditya, Das, Mili, Chakshusmathi, Ghadiyaram, Pandey, Suman, Dutta, Somnath, Varadarajan, Raghavan

“…Current influenza vaccines need to be updated annually due to mutations in the globular head of the viral surface protein, hemagglutinin (HA). To address this,…”
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Discovery of Pyridyl Bis(oxy)dibenzimidamide Derivatives as Selective Matriptase Inhibitors by Goswami, Rajeev, Mukherjee, Subhendu, Wohlfahrt, Gerd, Ghadiyaram, Chakshusmathi, Nagaraj, Jwala, Chandra, Beeram Ravi, Sistla, Ramesh K, Satyam, Leena K, Samiulla, Dodheri S, Moilanen, Anu, Subramanya, Hosahalli S, Ramachandra, Murali

“…Matriptase belongs to trypsin-like serine proteases involved in matrix remodeling/degradation, growth regulation, survival, motility, and cell morphogenesis…”
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Structure of the La motif: a winged helix domain mediates RNA binding via a conserved aromatic patch by Dong, Gang, Chakshusmathi, Ghadiyaram, Wolin, Sandra L, Reinisch, Karin M

“…The La protein is a ubiquitous nuclear phosphoprotein that recognizes the 3′ uridylates found in all newly synthesized RNA polymerase III transcripts. La…”
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Diphenylether derivative as selective inhibitor of protein tyrosine phosphatase 1B (PTP1B) over t-cell protein tyrosine phosphatase (TCPTP) identified through virtual screening by Reddy, M V V V Sekhar, Ghadiyaram, Chakshusmathi, Panigrahi, Sunil Kumar, Hosahalli, Subramanya, Mangamoori, Lakshmi Narasu

“…Even though protein tyrosine phosphatase has been identified as a validated therapeutic target over a decade for type II diabetes and obesity, developing a…”
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Design of Temperature-Sensitive Mutants Solely from Amino Acid Sequence by Chakshusmathi, Ghadiyaram, Mondal, Kajari, Lakshmi, G. Santosh, Singh, Guramrit, Roy, Ankita, Ch, Ravindra Babu, Madhusudhanan, S., Varadarajan, Raghavan, Kim, Peter S.

“…Temperature-sensitive (Ts) mutants are a powerful tool with which to study gene function in vivo. Ts mutants are typically generated by random mutagenesis…”
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3‑Alkoxy-pyrrolo[1,2‑b]pyrazolines as Selective Androgen Receptor Modulators with Ideal Physicochemical Properties for Transdermal Administration by Ullrich, Thomas, Sasmal, Sanjita, Boorgu, Venkatesham, Pasagadi, Srinivasu, Cheera, Srisailam, Rajagopalan, Sujatha, Bhumireddy, Archana, Shashikumar, Dhanya, Chelur, Shekar, Belliappa, Charamanna, Pandit, Chetan, Krishnamurthy, Narasimharao, Mukherjee, Subhendu, Ramanathan, Anuradha, Ghadiyaram, Chakshusmathi, Ramachandra, Murali, Santos, Paulo G, Lagu, Bharat, Bock, Mark G, Perrone, Mark H, Weiler, Sven, Keller, Hansjoerg

“…We describe the synthesis and characterization of 3-alkoxy-pyrrolo[1,2-b]pyrazolines as novel selective androgen receptor (AR) modulators that possess…”
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Discovery of O-(3-carbamimidoylphenyl)-l-serine amides as matriptase inhibitors using a fragment-linking approach by Goswami, Rajeev, Wohlfahrt, Gerd, Mukherjee, Subhendu, Ghadiyaram, Chakshusmathi, Nagaraj, Jwala, Satyam, Leena K., Subbarao, Krishnaprasad, Gopinath, Sreevalsam, Krishnamurthy, Narasimha R., Subramanya, Hosahalli S., Ramachandra, Murali

“…[Display omitted] Matriptase is a cell-surface trypsin-like serine protease of epithelial origin, which cleaves and activates proteins including hepatocyte…”
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Structure-guided discovery of 1,3,5 tri-substituted benzenes as potent and selective matriptase inhibitors exhibiting in vivo antitumor efficacy by Goswami, Rajeev, Mukherjee, Subhendu, Ghadiyaram, Chakshusmathi, Wohlfahrt, Gerd, Sistla, Ramesh K., Nagaraj, Jwala, Satyam, Leena K., Subbarao, Krishnaprasad, Palakurthy, Rajendra K., Gopinath, Sreevalsam, Krishnamurthy, Narasimha R., Ikonen, Tarja, Moilanen, Anu, Subramanya, Hosahalli S., Kallio, Pekka, Ramachandra, Murali

“…[Display omitted] Matriptase is a serine protease implicated in cancer invasion and metastasis. Expression of matriptase is frequently dysregulated in human…”
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A La protein requirement for efficient pre-tRNA folding by Chakshusmathi, Ghadiyaram, Kim, Sang Do, Rubinson, Douglas A., Wolin, Sandra L.

“…The La protein protects the 3′ ends of many nascent small RNAs from exonucleases. Here we report that La is required for efficient folding of certain…”
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The La protein functions redundantly with tRNA modification enzymes to ensure tRNA structural stability by Copela, Laura A, Chakshusmathi, Ghadiyaram, Sherrer, R Lynn, Wolin, Sandra L

“…Although the La protein stabilizes nascent pre-tRNAs from nucleases, influences the pathway of pre-tRNA maturation, and assists correct folding of certain…”
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Thermodynamic characterization of monomeric and dimeric forms of CcdB (controller of cell division or death B protein) by Bajaj, Kanika, Chakshusmathi, Ghadiyaram, Bachhawat-Sikder, Kiran, Surolia, Avadhesha, Varadarajan, Raghavan

“…The protein CcdB (controller of cell division or death B) is an F-plasmid-encoded toxin that acts as an inhibitor of Escherichia coli DNA gyrase. The stability…”
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