Therapeutic effects of EGCG: a patent review

Green tea contains polyphenolic flavanoids such as epigallocatechin-3- gallate (EGCG), epicatechin-3-gallate (ECG), epigallocatechin (EGC) and epicatechin (EC). EGCG is the most abundant and active compound in green tea. Extensive research has shown that it has significant antioxidant, anti-carcinog...

Full description

Saved in:

Bibliographic Details
Published in:	Expert opinion on therapeutic patents Vol. 26; no. 8; p. 907
Main Authors:	Chakrawarti, Leewanshi, Agrawal, Rishab, Dang, Shweta, Gupta, Sanjay, Gabrani, Reema
Format:	Journal Article
Language:	English
Published:	England 02-08-2016
Subjects:	Animals Anticarcinogenic Agents - administration & dosage Anticarcinogenic Agents - pharmacology Anticarcinogenic Agents - therapeutic use Antioxidants - administration & dosage Antioxidants - pharmacology Antioxidants - therapeutic use Catechin - administration & dosage Catechin - analogs & derivatives Catechin - pharmacology Catechin - therapeutic use Drug Delivery Systems Drug Design Humans Neuroprotective Agents - administration & dosage Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Patents as Topic Tea - chemistry antioxidant Anti-carcinogenic bioavailability metabolic diseases neuroprotective nanoencapsulation anti-microbial
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Green tea contains polyphenolic flavanoids such as epigallocatechin-3- gallate (EGCG), epicatechin-3-gallate (ECG), epigallocatechin (EGC) and epicatechin (EC). EGCG is the most abundant and active compound in green tea. Extensive research has shown that it has significant antioxidant, anti-carcinogenic, anti-microbial, and neuroprotective properties and has therapeutic potential against various human diseases. This review focuses on the applications of EGCG alone, and in combination with other compounds, for the treatment of various types of cancers, metabolic, neurodegenerative, and microbial diseases, and discusses its mechanism of action in cell line and animal modesl. Recent advances, which include the use of nanoencapsulated EGCG to enhance the drug delivery and reduce cell toxicity, have also been discussed along with the comprehensive analysis of the specific granted patents associated with EGCG. Under the current scenario, the role of EGCG as a therapeutic agent is being utilised and new approaches are being formulated to overcome the problem of stability and bioavailability of EGCG. EGCG and its derivatives could be used for the development of drugs for the treatment of cancer, as well as various microbial, metabolic, and neurodegenerative diseases.
ISSN:	1744-7674
DOI:	10.1080/13543776.2016.1203419