Search Results - "Chain, Robert"

Repurposing host-based therapeutics to control coronavirus and influenza virus by Li, Cui-Cui, Wang, Xiao-Jia, Wang, Hwa-Chain Robert

“…•Drug repositioning is a cost- and time-efficient approach for new indications.•Targeting host machineries, used by viruses, could develop broad-spectrum…”
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Long‐term exposure to extremely low‐dose of nicotine and 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK) induce non‐malignant breast epithelial cell transformation through activation of the a9‐nicotinic acetylcholine receptor‐mediated signaling pathway by Fararjeh, Abdul‐Fattah Salah, Tu, Shih‐Hsin, Chen, Li‐Ching, Cheng, Tzu‐Chun, Liu, Yun‐Ru, Chang, Hang‐Lung, Chang, Hui‐Wen, Huang, Chi‐Cheng, Wang, Hwa‐Chain Robert, Hwang‐Verslues, Wendy W., Wu, Chih‐Hsiung, Ho, Yuan‐Soon

“…Breast cancer (BC) is the most common cancer affecting women worldwide and has been associated with active tobacco smoking. Low levels of nicotine (Nic) and…”
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Reactive oxygen species-mediated synergistic and preferential induction of cell death and reduction of clonogenic resistance in breast cancer cells by combined cisplatin and FK228 by Pluchino, Lenora Ann, Choudhary, Shambhunath, Wang, Hwa-Chain Robert

“…Highlights • Cisplatin and FK228 synergistically and selectively induced breast cancer cell death. • Cisplatin and FK228 synergistically and selectively…”
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EGFR-ErbB2 dual kinase inhibitor lapatinib decreases autoantibody levels and worsens renal disease in Interferon α-accelerated murine lupus by Gallo, Paul M., Chain, Robert W., Xu, Jun, Whiteman, Leah M., Palladino, Annette, Caricchio, Roberto, Costa-Reis, Patricia, Sullivan, Kathleen E., Gallucci, Stefania

“…Working model. [Display omitted] •The expression of HER2/ErbB2, a member of the EGFR family that was found increased in kidneys of patients and mice with lupus…”
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Targeting nuclear proteins for control of viral replication by Meng, Wen, Wang, Xiao-Jia, Wang, Hwa-Chain Robert

“…Viruses are obligate intracellular parasites that exploit host cell machineries for replication. In this review, we focus on the current understanding of host…”
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Mesenchymal and stem-like cell properties targeted in suppression of chronically-induced breast cell carcinogenesis by Rathore, Kusum, Wang, Hwa-Chain Robert

“…Highlights ► Chronic exposure to low-dose carcinogens induces breast cell carcinogenesis. ► Stem-like cell populations are increased in breast cell…”
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A triple combination gemcitabine + romidepsin + cisplatin to effectively control triple-negative breast cancer tumor development, recurrence, and metastasis by Pattarawat, Pawat, Hunt, Jessica T., Poloway, Jacob, Archibald, Collin J., Wang, Hwa-Chain Robert

“…Purpose Triple-negative breast cancer (TNBC) is an aggressive, lethal, heterogeneous type of breast cancer (BC). TNBC tends to have a lower response rate to…”
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Formulation of a triple combination gemcitabine plus romidepsin + cisplatin regimen to efficaciously and safely control triple-negative breast cancer tumor development by Pattarawat, Pawat, Wallace, Shelby, Pfisterer, Bianca, Odoi, Agricola, Wang, Hwa-Chain Robert

“…Purpose Triple-negative breast cancer (TNBC) is an aggressive, lethal, and heterogeneous subtype of breast cancers, tending to have lower 5-year survival rates…”
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Green tea catechin extract in intervention of chronic breast cell carcinogenesis induced by environmental carcinogens by Rathore, Kusum, Wang, Hwa-Chain Robert

“…Sporadic breast cancers are mainly attributable to long‐term exposure to environmental factors, via a multi‐year, multi‐step, and multi‐path process of…”
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STAT2 Is Required for TLR-Induced Murine Dendritic Cell Activation and Cross-Presentation by Xu, Jun, Lee, Michael H, Chakhtoura, Marita, Green, Benjamin L, Kotredes, Kevin P, Chain, Robert W, Sriram, Uma, Gamero, Ana M, Gallucci, Stefania

“…TLR-stimulated cross-presentation by conventional dendritic cells (cDCs) is important in host defense and antitumor immunity. We recently reported that cDCs…”
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Compensatory combination of romidepsin with gemcitabine and cisplatin to effectively and safely control urothelial carcinoma by Pattarawat, Pawat, Hong, Tian, Wallace, Shelby, Hu, Yanchun, Donnell, Robert, Wang, Tzu-Hao, Tsai, Chia-Lung, Wang, Jinquan, Wang, Hwa-Chain Robert

“…Background Human urothelial carcinoma (UC) has a high tendency to recur and progress to life-threatening advanced diseases. Advanced therapeutic regimens are…”
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Induction of human breast cell carcinogenesis by triclocarban and intervention by curcumin by Sood, Shilpa, Choudhary, Shambhunath, Wang, Hwa-Chain Robert

“…•Triclocarban exposure induces breast epithelial cell carcinogenesis.•Triclocarban induces the Erk–Nox pathway, ROS elevation, and DNA damage.•Physiological…”
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Structure-Based Identification of Novel Histone Deacetylase 4 (HDAC4) Inhibitors by Agarwal, Rupesh, Pattarawat, Pawat, Duff, Michael R, Wang, Hwa-Chain Robert, Baudry, Jerome, Smith, Jeremy C

“…Histone deacetylases (HDACs) are important cancer drug targets. Existing FDA-approved drugs target the catalytic pocket of HDACs, which is conserved across…”
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Reactive oxygen species-mediated breast cell carcinogenesis enhanced by multiple carcinogens and intervened by dietary ergosterol and mimosine by Pluchino, Lenora Ann, Liu, Amethyst Kar-Yin, Wang, Hwa-Chain Robert

“…Most breast cancers occur sporadically due to long-term exposure to low-dose carcinogens in the diet and the environment. Specifically, smoke, polluted air,…”
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Dipyridamole intervention of breast cell carcinogenesis by Choudhary, Shambhunath, Sood, Shilpa, Wang, Hwa-Chain Robert

“…Dietary prevention is a cost‐efficient strategy to reduce the risk of human cancers. More than 85% breast cancers are sporadic and attributable to long‐term…”
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Chronic exposure to combined carcinogens enhances breast cell carcinogenesis with mesenchymal and stem-like cell properties by Pluchino, Lenora Ann, Wang, Hwa-Chain Robert

“…Breast cancer is the most common type of cancer affecting women in North America and Europe. More than 85% of breast cancers are sporadic and attributable to…”
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IL-4 suppresses the responses to TLR7 and TLR9 stimulation and increases the permissiveness to retroviral infection of murine conventional dendritic cells by Sriram, Uma, Xu, Jun, Chain, Robert W, Varghese, Linda, Chakhtoura, Marita, Bennett, Heather L, Zoltick, Philip W, Gallucci, Stefania

“…Th2-inducing pathological conditions such as parasitic diseases increase susceptibility to viral infections through yet unclear mechanisms. We have previously…”
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SOCS3 control the activity of NF-κB induced by HSP70 via degradation of MyD88-adapter-like protein (Mal) in IPEC-J2 cells by Yong, Yan-Hong, Wang, Ping, Jia, Ru-Min, Gooneratne, Ravi, Robert Wang, Hwa-Chain, Liao, Ming, Ju, Xiang-Hong

“…Hyperthermia in pigs induces suppressor of cytokine signaling (SOCS) 3 and SOCS4 expression in intestinal gut and causes disruption of inflammation cytokine…”
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Ethyl Pyruvate Modulates Murine Dendritic Cell Activation and Survival Through Their Immunometabolism by Chakhtoura, Marita, Chain, Robert W, Sato, Priscila Y, Qiu, Connie C, Lee, Michael H, Meissler, Joseph J, Eisenstein, Toby K, Koch, Walter J, Caricchio, Roberto, Gallucci, Stefania

“…Attenuating the innate immunity activation could ameliorate inflammation and disease in settings such as transplant rejection or autoimmunity. Recently, a…”
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Synergistic induction of cancer cell death and reduction of clonogenic resistance by cisplatin and FK228 by Choudhary, Shambhunath, Sood, Shilpa, Wang, Hwa-Chain Robert

“…•FK228 and cisplatin synergistically induced bladder cancer cell death.•FK228 and cisplatin synergistically reduced bladder cancer cell resistance.•The…”
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