Search Results - "Chain, Benjamin M."

Tissue CD14+CD8+ T cells reprogrammed by myeloid cells and modulated by LPS by Pallett, Laura J., Swadling, Leo, Diniz, Mariana, Maini, Alexander A., Schwabenland, Marius, Gasull, Adrià Dalmau, Davies, Jessica, Kucykowicz, Stephanie, Skelton, Jessica K., Thomas, Niclas, Schmidt, Nathalie M., Amin, Oliver E., Gill, Upkar S., Stegmann, Kerstin A., Burton, Alice R., Stephenson, Emily, Reynolds, Gary, Whelan, Matt, Sanchez, Jenifer, de Maeyer, Roel, Thakker, Clare, Suveizdyte, Kornelija, Uddin, Imran, Ortega-Prieto, Ana M., Grant, Charlotte, Froghi, Farid, Fusai, Giuseppe, Lens, Sabela, Pérez-del-Pulgar, Sofia, Al-Akkad, Walid, Mazza, Giuseppe, Noursadeghi, Mahdad, Akbar, Arne, Kennedy, Patrick T. F., Davidson, Brian R., Prinz, Marco, Chain, Benjamin M., Haniffa, Muzlifah, Gilroy, Derek W., Dorner, Marcus, Bengsch, Bertram, Schurich, Anna, Maini, Mala K.

“…The liver is bathed in bacterial products, including lipopolysaccharide transported from the intestinal portal vasculature, but maintains a state of tolerance…”
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Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function by Thomas, Sharyn, Mohammed, Fiyaz, Reijmers, Rogier M., Woolston, Annemarie, Stauss, Theresa, Kennedy, Alan, Stirling, David, Holler, Angelika, Green, Louisa, Jones, David, Matthews, Katherine K., Price, David A., Chain, Benjamin M., Heemskerk, Mirjam H. M., Morris, Emma C., Willcox, Benjamin E., Stauss, Hans J.

“…TCR-gene-transfer is an efficient strategy to produce therapeutic T cells of defined antigen specificity. However, there are substantial variations in the cell…”
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Hybrid epidemics--a case study on computer worm conficker by Zhang, Changwang, Zhou, Shi, Chain, Benjamin M

“…Conficker is a computer worm that erupted on the Internet in 2008. It is unique in combining three different spreading strategies: local probing, neighbourhood…”
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In Vivo Molecular Dissection of the Effects of HIV-1 in Active Tuberculosis by Bell, Lucy C K, Pollara, Gabriele, Pascoe, Mellissa, Tomlinson, Gillian S, Lehloenya, Rannakoe J, Roe, Jennifer, Meldau, Richard, Miller, Robert F, Ramsay, Alan, Chain, Benjamin M, Dheda, Keertan, Noursadeghi, Mahdad

“…Increased risk of tuberculosis (TB) associated with HIV-1 infection is primarily attributed to deficient T helper (Th)1 immune responses, but most people with…”
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Hybrid spreading mechanisms and T cell activation shape the dynamics of HIV-1 infection by Zhang, Changwang, Zhou, Shi, Groppelli, Elisabetta, Pellegrino, Pierre, Williams, Ian, Borrow, Persephone, Chain, Benjamin M, Jolly, Clare

“…HIV-1 can disseminate between susceptible cells by two mechanisms: cell-free infection following fluid-phase diffusion of virions and by highly-efficient…”
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Validation of Immune Cell Modules in Multicellular Transcriptomic Data by Pollara, Gabriele, Murray, Matthew J, Heather, James M, Byng-Maddick, Rachel, Guppy, Naomi, Ellis, Matthew, Turner, Carolin T, Chain, Benjamin M, Noursadeghi, Mahdad

“…Numerous gene signatures, or modules have been described to evaluate the immune cell composition in transcriptomes of multicellular tissue samples. However,…”
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Single-cell analysis of bronchoalveolar cells in inflammatory and fibrotic post-COVID lung disease by Mehta, Puja, Sanz-Magallón Duque de Estrada, Blanca, Denneny, Emma K, Foster, Kane, Turner, Carolin T, Mayer, Andreas, Milighetti, Martina, Platé, Manuela, Worlock, Kaylee B, Yoshida, Masahiro, Brown, Jeremy S, Nikolić, Marko Z, Chain, Benjamin M, Noursadeghi, Mahdad, Chambers, Rachel C, Porter, Joanna C, Tomlinson, Gillian S

“…Persistent radiological lung abnormalities are evident in many survivors of acute coronavirus disease 2019 (COVID-19). Consolidation and ground glass opacities…”
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The impact of DNA topology on polyplex uptake and transfection efficiency in mammalian cells by Dhanoya, Arjun, Chain, Benjamin M., Keshavarz-Moore, Eli

“…The effect of DNA vector topology when complexed to poly- l-lysine (PLL) and its quantification in transfection efficiency has not been fully addressed even…”
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Identification of Therapeutic Targets of Inflammatory Monocyte Recruitment to Modulate the Allogeneic Injury to Donor Cornea by Lapp, Thabo, Zaher, Sarah S, Haas, Carolin T, Becker, David L, Thrasivoulou, Chris, Chain, Benjamin M, Larkin, Daniel F P, Noursadeghi, Mahdad

“…We sought to test the hypothesis that monocytes contribute to the immunopathogenesis of corneal allograft rejection and identify therapeutic targets to inhibit…”
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Adherent human alveolar macrophages exhibit a transient pro-inflammatory profile that confounds responses to innate immune stimulation by Tomlinson, Gillian S, Booth, Helen, Petit, Sarah J, Potton, Elspeth, Towers, Greg J, Miller, Robert F, Chain, Benjamin M, Noursadeghi, Mahdad

“…Alveolar macrophages (AM) are thought to have a key role in the immunopathogenesis of respiratory diseases. We sought to test the hypothesis that human AM…”
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The "Achilles' Heel" of Cancer and Its Implications for the Development of Novel Immunotherapeutic Strategies by Joshi, Kroopa, Chain, Benjamin M, Peggs, Karl S, Quezada, Sergio A

“…Over the last century, scientists have embraced the idea of mobilizing antitumor immune responses in patients with cancer. In the last decade, we have seen the…”
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DC priming by M. vaccae inhibits Th2 responses in contrast to specific TLR2 priming and is associated with selective activation of the CREB pathway by Le Bert, Nina, Chain, Benjamin M, Rook, Graham, Noursadeghi, Mahdad

“…The environmental mycobacterium, M. vaccae has been used in mouse models to support the contemporary hygiene hypothesis that non-pathogenic microorganisms…”
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Application of T cell receptor (TCR) repertoire analysis for the advancement of cancer immunotherapy by Joshi, Kroopa, Milighetti, Martina, Chain, Benjamin M

“…•TCR repertoire analysis as a tool to advance cancer immunotherapy.•Computational methods are used to understand TCR repertoire characteristics.•Both TCR…”
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Transcriptional Profiling of Endobronchial Ultrasound-Guided Lymph Node Samples Aids Diagnosis of Mediastinal Lymphadenopathy by Tomlinson, Gillian S., PhD, Thomas, Niclas, PhD, Chain, Benjamin M., PhD, Best, Katharine, MRes, Simpson, Nandi, PhD, Hardavella, Georgia, PhD, Brown, James, MD, Bhowmik, Angshu, MD, Navani, Neal, PhD, Janes, Samuel M., PhD, Miller, Robert F., MBBS, Noursadeghi, Mahdad, PhD

“…Background Endobronchial ultrasound (EBUS)-guided biopsy is the mainstay for investigation of mediastinal lymphadenopathy for laboratory diagnosis of…”
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HIV-1 Infection of Macrophages Dysregulates Innate Immune Responses to Mycobacterium tuberculosis by Inhibition of Interleukin-10 by Tomlinson, Gillian S., Bell, Lucy C. K., Walker, Naomi F., Tsang, Jhen, Brown, Jeremy S., Breen, Ronan, Lipman, Marc, Katz, David R., Miller, Robert F., Chain, Benjamin M., Elkington, Paul T. G., Noursadeghi, Mahdad

“…Human immunodeficiency virus (HIV)-1 and Mycobacterium tuberculosis (M. tuberculosis) both target macrophages, which are key cells in inflammatory responses…”
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Climate Change Affects Health: Are We Listening? by Chain, Gabriel S., Chain, Benjamin M., Pelliccia, Frances B.

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A Quantitative Proteomics Design for Systematic Identification of Protease Cleavage Events by Impens, Francis, Colaert, Niklaas, Helsens, Kenny, Ghesquière, Bart, Timmerman, Evy, De Bock, Pieter-Jan, Chain, Benjamin M., Vandekerckhove, Joël, Gevaert, Kris

“…We present here a novel proteomics design for systematic identification of protease cleavage events by quantitative N-terminal proteomics, circumventing the…”
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Role of DNA topology in uptake of polyplex molecules by dendritic cells by Dhanoya, Arjun, Chain, Benjamin M, Keshavarz-Moore, Eli

“…Highlights ► This novel study quantifies the effect of DNA topology on polyplex uptake in DCs. ► Polyplex uptake was monitored by microscopy and gene…”
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Understanding HSV-1 entry glycoproteins by Reske, Adi, Pollara, Gabriele, Krummenacher, Claude, Chain, Benjamin M., Katz, David R.

“…Herpes Simplex Virus‐1 is a common infectious agent, but the precise detail of entry and infection of cells has only now begun to be clarified. Four viral…”
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Glycoprotein-Dependent and TLR2-Independent Innate Immune Recognition of Herpes Simplex Virus-1 by Dendritic Cells by Reske, Adi, Pollara, Gabriele, Krummenacher, Claude, Katz, David R, Chain, Benjamin M

“…Innate immune recognition is an important early event in the host response to herpes simplex virus-1 (HSV-1) infection. Dendritic cells (DC) play an important…”
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