Search Results - "Chaimowitz, Natalia S."

Fyn kinase is required for optimal humoral responses by Chaimowitz, Natalia S, Falanga, Yves T, Ryan, John J, Conrad, Daniel H

“…The generation of antigen-specific antibodies and the development of immunological memory require collaboration between B and T cells. T cell-secreted IL-4 is…”
Get full text

A Novel STAT3 Mutation in a Qatari Patient With Hyper-IgE Syndrome by Chaimowitz, Natalia S, Branch, Justin, Reyes, Anaid, Vargas-Hernández, Alexander, Orange, Jordan S, Forbes, Lisa R, Ehlayel, Mohammed, Purayil, Saleema C, Al-Nesf, Maryam Ali, Vogel, Tiphanie P

“…Autosomal dominant hyper-IgE syndrome caused by mutations in the transcription factor STAT3 (AD-HIES) is characterized by a collection of immunologic and…”
Get full text

STAT1 Gain of Function, Type 1 Diabetes, and Reversal with JAK Inhibition by Chaimowitz, Natalia S, Ebenezer, Sophia J, Hanson, I. Celine, Anderson, Mark, Forbes, Lisa R

“…This letter describes the case of an adolescent boy with heterozygous STAT1 gain-of-function syndrome and type 1 diabetes. Diabetes and other features of the…”
Get full text

ADAM10 regulates transcription factor expression required for plasma cell function by Chaimowitz, Natalia S, Kang, Dae-Joong, Dean, Lee M, Conrad, Daniel H

“…A disintegrin and metalloprotease 10 (ADAM10) is a key regulator of cellular processes by shedding extracellular domains of transmembrane proteins. We have…”
Get full text

JAK/STAT defects and immune dysregulation, and guiding therapeutic choices by Chaimowitz, Natalia S., Smith, Madison R., Forbes Satter, Lisa R.

“…Summary Inborn errors of immunity (IEIs) encompass a diverse spectrum of genetic disorders that disrupt the intricate mechanisms of the immune system, leading…”
Get full text

Characterization of Transcriptional Regulatory Networks that Promote and Restrict Identities and Functions of Intestinal Innate Lymphoid Cells by Pokrovskii, Maria, Hall, Jason A., Ochayon, David E., Yi, Ren, Chaimowitz, Natalia S., Seelamneni, Harsha, Carriero, Nicholas, Watters, Aaron, Waggoner, Stephen N., Littman, Dan R., Bonneau, Richard, Miraldi, Emily R.

“…Innate lymphoid cells (ILCs) promote tissue homeostasis and immune defense but also contribute to inflammatory diseases. ILCs exhibit phenotypic and functional…”
Get full text

More on STAT1 Gain of Function, Type 1 Diabetes, and JAK Inhibition. Reply by Anderson, Mark S, Chaimowitz, Natalia S, Forbes, Lisa R

Get full text

Human diseases caused by impaired signal transducer and activator of transcription and Janus kinase signaling by Chaimowitz, Natalia S, Forbes, Lisa R

“…The Janus kinase (JAK) and signal transducer of activation (STAT) pathway plays a key role in the immune system. It is employed by diverse cytokines,…”
Get full text

Genetic errors of immunity distinguish pediatric nonmalignant lymphoproliferative disorders by Forbes, Lisa R., Eckstein, Olive S., Gulati, Nitya, Peckham-Gregory, Erin C., Ozuah, Nmazuo W., Lubega, Joseph, El-Mallawany, Nader K., Agrusa, Jennifer E., Poli, M. Cecilia, Vogel, Tiphanie P., Chaimowitz, Natalia S., Rider, Nicholas L., Mace, Emily M., Orange, Jordan S., Caldwell, Jason W., Aldave-Becerra, Juan C., Jolles, Stephen, Saettini, Francesco, Chong, Hey J., Stray-Pedersen, Asbjorg, Heslop, Helen E., Kamdar, Kala Y., Rouce, R. Helen, Muzny, Donna M., Jhangiani, Shalini N., Gibbs, Richard A., Coban-Akdemir, Zeynep H., Lupski, James R., McClain, Kenneth L., Allen, Carl E., Chinn, Ivan K.

“…Pediatric nonmalignant lymphoproliferative disorders (PLPDs) are clinically and genetically heterogeneous. Long-standing immune dysregulation and…”
Get full text

The emergence of ADAM10 as a regulator of lymphocyte development and autoimmunity by Gibb, David R., Saleem, Sheinei J., Chaimowitz, Natalia S., Mathews, Joel, Conrad, Daniel H.

“…Proteolytic processing of transmembrane receptors and ligands can have a dramatic impact on cell signaling processes and subsequent cellular responses,…”
Get full text

Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis by Falanga, Yves T, Chaimowitz, Natalia S, Charles, Nicolas, Finkelman, Fred D, Pullen, Nicholas A, Barbour, Suzanne, Dholaria, Kevin, Faber, Travis, Kolawole, Motunrayo, Huang, Bernice, Odom, Sandra, Rivera, Juan, Carlyon, Jason, Conrad, Daniel H, Spiegel, Sarah, Oskeritzian, Carole A, Ryan, John J

“…Anaphylaxis is a rapid, life-threatening hypersensitivity reaction. Until recently, it was mainly attributed to histamine released by mast cells activated by…”
Get full text

A disintegrin and metalloproteinase 10 regulates antibody production and maintenance of lymphoid architecture by Chaimowitz, Natalia S, Martin, Rebecca K, Cichy, Joanna, Gibb, David R, Patil, Pooja, Kang, Dae-Joong, Farnsworth, Julie, Butcher, Eugene C, McCright, Brent, Conrad, Daniel H

“…A disintegrin and metalloproteinase 10 (ADAM10) is a zinc-dependent proteinase related to matrix metalloproteinases. ADAM10 has emerged as a key regulator of…”
Get full text

More on STAT1 Gain of Function, Type 1 Diabetes, and JAK Inhibition by Johnson, Matthew B, Hattersley, Andrew T, Patel, Kashayp A, Anderson, Mark S, Chaimowitz, Natalia S, Forbes, Lisa R

“…To the Editor: Chaimowitz et al. (Oct. 8 issue) 1 report diabetes remission following ruxolitinib treatment in a patient with a signal transducer and activator…”
Get full text

Role for B-cell lymphoma 6 in intestinal innate lymphoid cell homeostasis and inflammatory disease by Ohayon, David E, Seelamneni, Harsha, Chaimowitz, Natalia S, Cazares, Tareian, Waddell, Amanda, Huber, Alex, Kotey, Amos, Rosen, Michael J, Miraldi, Emily R, Waggoner, Stephen N

“…Abstract Group 3 innate lymphoid cells (ILC3) are critical for intestinal homeostasis. The functional activity of ILC3 must be tightly regulated as cytokines…”
Get full text

Infections in Infants with SCID: Isolation, Infection Screening, and Prophylaxis in PIDTC Centers by Dorsey, Morna J., Wright, Nicola A. M., Chaimowitz, Natalia S., Dávila Saldaña, Blachy J., Miller, Holly, Keller, Michael D., Thakar, Monica S., Shah, Ami J., Abu-Arja, Rolla, Andolina, Jeffrey, Aquino, Victor, Barnum, J. L., Bednarski, Jeffrey J., Bhatia, Monica, Bonilla, Francisco A., Butte, Manish J., Bunin, Nancy J., Chandra, Sharat, Chaudhury, Sonali, Chen, Karin, Chong, Hey, Cuvelier, Geoffrey D. E., Dalal, Jignesh, DeFelice, Magee L., DeSantes, Kenneth B., Forbes, Lisa R., Gillio, Alfred, Goldman, Fred, Joshi, Avni Y., Kapoor, Neena, Knutsen, Alan P., Kobrynski, Lisa, Lieberman, Jay A., Leiding, Jennifer W., Oshrine, Benjamin, Patel, Kiran P., Prockop, Susan, Quigg, Troy C., Quinones, Ralph, Schultz, Kirk R., Seroogy, Christine, Shyr, David, Siegel, Subhadra, Smith, Angela R., Torgerson, Troy R., Vander Lugt, Mark T., Yu, Lolie C., Cowan, Morton J., Buckley, Rebecca H., Dvorak, Christopher C., Griffith, Linda M., Haddad, Elie, Kohn, Donald B., Logan, Brent, Notarangelo, Luigi D., Pai, Sung-Yun, Puck, Jennifer, Pulsipher, Michael A., Heimall, Jennifer

“…Purpose The Primary Immune Deficiency Treatment Consortium (PIDTC) enrolled children with severe combined immunodeficiency (SCID) in a prospective natural…”
Get full text

Genetic errors of immunity distinguish pediatric non-malignant lymphoproliferative disorders by Forbes, Lisa R., Eckstein, Olive S., Gulati, Nitya, Peckham-Gregory, Erin C., Ozuah, Nmazuo W., Lubega, Joseph, El-Mallawany, Nader K., Agrusa, Jennifer, Poli, M. Cecilia, Vogel, Tiphanie P., Chaimowitz, Natalia S., Rider, Nicholas L., Mace, Emily M., Orange, Jordan S., Caldwell, Jason W., Aldave-Becerra, Juan C., Jolles, Stephen, Saettini, Francesco, Chong, Hey J., Stray-Pedersen, Asbjorg, Heslop, Helen E., Kamdar, Kala Y., Rouce, R. Helen, Muzny, Donna M., Jhangiani, Shalini N., Gibbs, Richard A., Coban-Akdemir, Zeynep H., Lupski, James R., McClain, Kenneth L., Allen, Carl E., Chinn, Ivan K.

“…Genetic errors of immunity are prevalent in children who meet criteria for PLPD yet correlate with improved survival. EBV-PLPD without a genetic explanation is…”
Get full text

Correction to: Infections in Infants with SCID: Isolation, Infection Screening and Prophylaxis in PIDTC Centers by Dorsey, Morna, Wright, Nicola A. M., Chaimowitz, Natalia S., Dávila Saldaña, Blachy J., Miller, Holly, Keller, Michael D., Thakar, Monica S., Shah, Ami J., Abu-Arja, Rolla, Andolina, Jeffrey, Aquino, Victor, Barnum, J. L., Bednarski, Jeffrey J., Bhatia, Monica, Bonilla, Francisco A., Butte, Manish J., Bunin, Nancy J., Burroughs, Lauri M., Chandra, Sharat, Chaudhury, Sonali, Chen, Karin, Chong, Hey, Cuvelier, Geoff, Dalal, Jignesh, DeFelice, Magee L., DeSantes, Kenneth B., Forbes, Lisa R., Gillio, Alfred, Goldman, Fred, Joshi, Avni Y., Kapoor, Neena, Knutsen, Alan P., Kobrynski, Lisa, Lieberman, Jay A., Leiding, Jennifer W., Oshrine, Benjamin, Patel, Kiran P., Prockop, Susan, Quigg, Troy C., Quinones, Ralph, Schultz, Kirk R., Seroogy, Christine, Shyr, David, Siegel, Subhadra, Smith, Angela R., Torgerson, Troy R., Vander Lugt, Mark T., Yu, Lolie C., Cowan, Morton J., Buckley, Rebecca H., Dvorak, Christopher C., Griffith, Linda M., Haddad, Elie, Kohn, Donald B., Logan, Brent, Notarangelo, Luigi D., Pai, Sung-Yun, Puck, Jennifer, Pulsipher, Michael A., Heimall, Jennifer

“…A Correction to this paper has been published: https://doi.org/10.1007/s10875-020-00917-0…”
Get full text

ADAM10 regulates antibody production and maintenance of lymphoid architecture1 by Chaimowitz, Natalia S., Martin, Rebecca K., Cichy, Joanna, Gibb, David R., Patil, Pooja, Kang, Dae-Joong, Farnsworth, Julie, Butcher, Eugene C., McCright, Brent, Conrad, Daniel H.

“…A disintegrin and metalloproteinase 10 (ADAM10) is a zinc dependent proteinase related to matrix metalloproteinases. ADAM10 has emerged as a key regulator of…”
Get full text

Fyn Kinase Is Required for Optimal Humoral Responses. e60640 by Chaimowitz, Natalia S, Falanga, Yves T, Ryan, John J, Conrad, Daniel H

“…The generation of antigen-specific antibodies and the development of immunological memory require collaboration between B and T cells. T cell-secreted IL-4 is…”
Get full text

STAT1 Gain of Function, Type 1 Diabetes, and Reversal with JAK Inhibition by Chaimowitz, Natalia S, Ebenezer, Sophia J, Hanson, I Celine, Anderson, Mark, bes, Lisa R

Get full text