Search Results - "Chaikovsky, Andrea"

α-Ketoglutarate Accelerates the Initial Differentiation of Primed Human Pluripotent Stem Cells by TeSlaa, Tara, Chaikovsky, Andrea C., Lipchina, Inna, Escobar, Sandra L., Hochedlinger, Konrad, Huang, Jing, Graeber, Thomas G., Braas, Daniel, Teitell, Michael A.

“…Pluripotent stem cells (PSCs) can self-renew or differentiate from naive or more differentiated, primed, pluripotent states established by specific culture…”
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Beyond the Cell Cycle: Enhancing the Immune Surveillance of Tumors Via CDK4/6 Inhibition by Chaikovsky, Andrea C, Sage, Julien

“…Inhibitors of the cyclin-dependent kinases 4 and 6 (CDK4/6) were originally designed to block proliferation and cell cycle progression of cancer cells in which…”
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The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D by Chaikovsky, Andrea C., Li, Chuan, Jeng, Edwin E., Loebell, Samuel, Lee, Myung Chang, Murray, Christopher W., Cheng, Ran, Demeter, Janos, Swaney, Danielle L., Chen, Si-Han, Newton, Billy W., Johnson, Jeffrey R., Drainas, Alexandros P., Shue, Yan Ting, Seoane, Jose A., Srinivasan, Preethi, He, Andy, Yoshida, Akihiro, Hipkins, Susan Q., McCrea, Edel, Poltorack, Carson D., Krogan, Nevan J., Diehl, J. Alan, Kong, Christina, Jackson, Peter K., Curtis, Christina, Petrov, Dmitri A., Bassik, Michael C., Winslow, Monte M., Sage, Julien

“…The initiation of cell division integrates a large number of intra- and extracellular inputs. D-type cyclins (hereafter, cyclin D) couple these inputs to the…”
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RB1 Deletion in Retinoblastoma Protein Pathway-Disrupted Cells Results in DNA Damage and Cancer Progression by Marshall, Aren E., Roes, Michael V., Passos, Daniel T., DeWeerd, Megan C., Chaikovsky, Andrea C., Sage, Julien, Howlett, Christopher J., Dick, Frederick A.

“…Proliferative control in cancer cells is frequently disrupted by mutations in the retinoblastoma protein (RB) pathway. Intriguingly, RB1 mutations can arise…”
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E2F4 regulates transcriptional activation in mouse embryonic stem cells independently of the RB family by Hsu, Jenny, Arand, Julia, Chaikovsky, Andrea, Mooney, Nancie A., Demeter, Janos, Brison, Caileen M., Oliverio, Romane, Vogel, Hannes, Rubin, Seth M., Jackson, Peter K., Sage, Julien

“…E2F transcription factors are central regulators of cell division and cell fate decisions. E2F4 often represents the predominant E2F activity in cells. E2F4 is…”
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The Long-Lost Ligase: CRL4 AMBRA1 Regulates the Stability of D-Type Cyclins by Chaikovsky, Andrea C, Sage, Julien, Pagano, Michele, Simoneschi, Daniele

“…D-type cyclins (cyclin D1, D2, and D3, together cyclin D) are central drivers of the cell division cycle and well-described proto-oncoproteins. Rapid turnover…”
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Intertumoral Heterogeneity in SCLC Is Influenced by the Cell Type of Origin by Yang, Dian, Denny, Sarah K, Greenside, Peyton G, Chaikovsky, Andrea C, Brady, Jennifer J, Ouadah, Youcef, Granja, Jeffrey M, Jahchan, Nadine S, Lim, Jing Shan, Kwok, Shirley, Kong, Christina S, Berghoff, Anna S, Schmitt, Anna, Reinhardt, H Christian, Park, Kwon-Sik, Preusser, Matthias, Kundaje, Anshul, Greenleaf, William J, Sage, Julien, Winslow, Monte M

“…The extent to which early events shape tumor evolution is largely uncharacterized, even though a better understanding of these early events may help identify…”
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RB depletion is required for the continuous growth of tumors initiated by loss of RB by Doan, Alex, Arand, Julia, Gong, Diana, Drainas, Alexandros P, Shue, Yan Ting, Lee, Myung Chang, Zhang, Shuyuan, Walter, David M, Chaikovsky, Andrea C, Feldser, David M, Vogel, Hannes, Dow, Lukas E, Skotheim, Jan M, Sage, Julien

“…The retinoblastoma (RB) tumor suppressor is functionally inactivated in a wide range of human tumors where this inactivation promotes tumorigenesis in part by…”
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Using CDK4/6 Inhibitors to Identify Novel Regulators of the RB Pathway by Chaikovsky, Andrea Christine

“…The initiation of cell division is a fundamental cellular process that integrates a large number of intra- and extra-cellular inputs. In mammalian cells,…”
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RB depletion is required for the continuous growth of tumors initiated by loss of RB by Alex Doan, Julia Arand, Diana Gong, Alexandros P. Drainas, Yan Ting Shue, Myung Chang Lee, Shuyuan Zhang, David M. Walter, Andrea C. Chaikovsky, David M. Feldser, Hannes Vogel, Lukas E. Dow, Jan M. Skotheim, Julien Sage

“…The retinoblastoma (RB) tumor suppressor is functionally inactivated in a wide range of human tumors where this inactivation promotes tumorigenesis in part by…”
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