Search Results - "Chaignon, Philippe"

The Reductive Dehydroxylation Catalyzed by IspH, a Source of Inspiration for the Development of Novel Anti-Infectives by Jobelius, Hannah, Bianchino, Gabriella Ines, Borel, Franck, Chaignon, Philippe, Seemann, Myriam

“…The non-mevalonate or also called MEP pathway is an essential route for the biosynthesis of isoprenoid precursors in most bacteria and in microorganisms…”
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The Reductive Dehydroxylation Catalyzed by IspH, a Source of Inspiration for the Development of Novel Anti-Infectives by Jobelius, Hannah, Bianchino, Gabriella, Borel, Franck, Chaignon, Philippe, Seemann, Myriam

“…The non-mevalonate or also called MEP pathway is an essential route for the biosynthesis of isoprenoid precursors in most bacteria and in microorganisms…”
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Photochemical Reactivity of Trifluoromethyl Aromatic Amines: The Example of 3,5-diamino-trifluoromethyl-benzene (3,5-DABTF) by Chaignon, Philippe, Cortial, Sylvie, Guerineau, Vincent, Adeline, Marie-Thérèse, Giannotti, Charles, Fan, Gérard, Ouazzani, Jamal

“…This work presents the application of an on-line photoreactor to the detection of 3,5-diamino-trifluoromethyl-benzene (3,5-DABTF) in aqueous solutions. When…”
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Synthesis and kinetic evaluation of analogs of (E)-4-amino-3-methylbut-2-en-1-yl diphosphate, a potent inhibitor of the IspH metalloenzyme by Petit, Benoît Eric, Jobelius, Hannah, Bianchino, Gabriella Ines, Guérin, Mélina, Borel, Franck, Chaignon, Philippe, Seemann, Myriam

“…Our previous research revealed that (E)-4-amino-3-methylbut-2-en-1-yl diphosphate (AMBPP) is one of the best inhibitors of IspH, a [4Fe-4S]-dependent enzyme…”
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Towards Bacterial Resistance via the Membrane Strategy: Enzymatic, Biophysical and Biomimetic Studies of the Lipid cis‐trans Isomerase of Pseudomonas aeruginosa by Mauger, Mickaël, Makarchuk, Iryna, Molter, Yasmin, Sansone, Anna, Melin, Frédéric, Chaignon, Philippe, Schaeffer, Philippe, Adam, Pierre, Schünemann, Volker, Hellwig, Petra, Ferreri, Carla, Chatgilialoglu, Chryssostomos, Seemann, Myriam

“…The lipid cis‐trans isomerase (Cti) is a periplasmic heme‐c enzyme found in several bacteria including Pseudomonas aeruginosa, a pathogen known for causing…”
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Carbohydrate-Templated Syntheses of Trifluoromethyl-Substituted MEP Analogues for the Study of the Methylerythritol Phosphate Pathway by Simonet, Basile, Herrscher, Vivien, Witjaksono, Clea, Chaignon, Philippe, Massicot, Fabien, Vasse, Jean-Luc, Seemann, Myriam, Behr, Jean-Bernard

“…Trifluoromethyl analogues of methylerythritol phosphate (MEP) and 2-C-methyl-erythritol 2,4-cyclodiphosphate (MEcPP), natural substrates of key enzymes from…”
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Methylerythritol Phosphate Pathway: Enzymatic Evidence for a Rotation in the LytB/IspH‐Catalyzed Reaction by Chaignon, Philippe, Petit, Benoît Eric, Vincent, Bruno, Allouche, Lionel, Seemann, Myriam

“…IspH/LytB, an oxygen‐sensitive [4Fe‐4S] enzyme, catalyzes the last step of the methylerythritol phosphate (MEP) pathway, a target for the development of new…”
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Synthesis and Kinetic evaluation of an azido analogue of methylerythritol phosphate: a Novel Inhibitor of E. coli YgbP/IspD by Baatarkhuu, Zoljargal, Chaignon, Philippe, Borel, Franck, Ferrer, Jean-Luc, Wagner, Alain, Seemann, Myriam

“…As multidrug resistant pathogenic microorganisms are a serious health menace, it is crucial to continuously develop novel medicines in order to overcome the…”
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Further Insight into Crystal Structures of Escherichia coli IspH/LytB in Complex with Two Potent Inhibitors of the MEP Pathway: A Starting Point for Rational Design of New Antimicrobials by Borel, Franck, Barbier, Elodie, Krasutsky, Sergiy, Janthawornpong, Karnjapan, Chaignon, Philippe, Poulter, C. Dale, Ferrer, Jean‐Luc, Seemann, Myriam

“…IspH, also called LytB, a protein involved in the biosynthesis of isoprenoids through the methylerythritol phosphate pathway, is an attractive target for the…”
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Biofilms of clinical strains of Staphylococcus that do not contain polysaccharide intercellular adhesin by Kogan, Grigorij, Sadovskaya, Irina, Chaignon, Philippe, Chokr, Ali, Jabbouri, Saïd

“…Abstract Twenty-seven Lactobacillus plantarum ssp. plantarum, 11 Lactobacillus paraplantarum and five Lactobacillus casei-related strains, isolated from…”
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Isoprenoid Biosynthesis in Pathogenic Bacteria: Nuclear Resonance Vibrational Spectroscopy Provides Insight into the Unusual [4Fe-4S] Cluster of the E.coli LytB/IspH Protein by Faus, Isabelle, Reinhard, Annegret, Rackwitz, Sergej, Wolny, Juliusz A, Schlage, Kai, Wille, Hans-Christian, Chumakov, Aleksandr, Krasutsky, Sergiy, Chaignon, Philippe, Poulter, C Dale, Seemann, Myriam, Schunemann, Volker

“…The LytB/IspH protein catalyzes the last step of the methylerythritol phosphate (MEP) pathway which is used for the biosynthesis of essential terpenoids in…”
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Isoprenoid Biosynthesis in Pathogenic Bacteria: Nuclear Resonance Vibrational Spectroscopy Provides Insight into the Unusual [4Fe-4S] Cluster of the E. coli LytB/IspH Protein by Faus, Isabelle, Reinhard, Annegret, Rackwitz, Sergej, Wolny, Juliusz A., Schlage, Kai, Wille, Hans-Christian, Chumakov, Aleksandr, Krasutsky, Sergiy, Chaignon, Philippe, Poulter, C. Dale, Seemann, Myriam, Schünemann, Volker

“…The LytB/IspH protein catalyzes the last step of the methylerythritol phosphate (MEP) pathway which is used for the biosynthesis of essential terpenoids in…”
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Inhibition of IspH, a [4Fe–4S]2+ Enzyme Involved in the Biosynthesis of Isoprenoids via the Methylerythritol Phosphate Pathway by Janthawornpong, Karnjapan, Krasutsky, Sergiy, Chaignon, Philippe, Rohmer, Michel, Poulter, C. Dale, Seemann, Myriam

“…The MEP pathway, which is absent in animals but present in most pathogenic bacteria, in the parasite responsible for malaria and in plant plastids, is a target…”
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Inhibition of IspH, a [4Fe-4S]2+ enzyme involved in the biosynthesis of isoprenoids via the MEP pathway by Janthawornpong, Karnjapan, Krasutsky, Sergiy, Chaignon, Philippe, Rohmer, Michel, Poulter, C. Dale, Seemann, Myriam

“…The MEP pathway, which is absent in animals but present in most pathogenic bacteria, in the parasite responsible for malaria and in plant plastids, is a target…”
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Dehydrogenation, oxidative denitration and ring contraction of N,N-dimethyl-5-nitrouracil by a Bacillus nitroreductase Nfr-A1 by Cortial, Sylvie, Chaignon, Philippe, Sergent, Didier, Dezard, Sophie, Ouazzani, Jamal

“…NfrA1, the oxygen insensitive Bacillus subtilis nitroreductase, catalyzes in the presence of NADH, the reduction and oxidation of (N,N)-dimethyl-5-nitrouracil…”
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NADH oxidase activity of Bacillus subtilis nitroreductase NfrA1: Insight into its biological role by Cortial, Sylvie, Chaignon, Philippe, Iorga, Bogdan I., Aymerich, Stéphane, Truan, Gilles, Gueguen-Chaignon, Virginie, Meyer, Philippe, Moréra, Solange, Ouazzani, Jamal

“…NfrA1 nitroreductase from the Gram-positive bacterium Bacillus subtilis is a member of the NAD(P)H/FMN oxidoreductase family. Here, we investigated the…”
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Dehydrogenation, oxidative denitration and ring contraction of N,N-dinnethyl-5-nitrouracil by a Bacillus nitroreductase Nfr-A1 by Cortial, S., Chaignon, P., Sergent, D., Dezard, S., Ouazzani, J.

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Isoprenoidbiosynthese in pathogenen Bakterien: Nukleare inelastische Streuung ermöglicht Einblicke in den ungewöhnlichen [4Fe‐4S]‐Cluster vom E.‐coli‐Protein LytB/IspH by Faus, Isabelle, Reinhard, Annegret, Rackwitz, Sergej, Wolny, Juliusz A., Schlage, Kai, Wille, Hans‐Christian, Chumakov, Aleksandr, Krasutsky, Sergiy, Chaignon, Philippe, Poulter, C. Dale, Seemann, Myriam, Schünemann, Volker

“…Das Protein LytB/ISPH katalysiert den letzten Schritt des Methylerythritolphosphat(MEP)‐Wegs, der zur Terpenoidbiosynthese in vielen pathogenen Bakterien…”
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Carbohydrate‐containing components of biofilms produced in vitro by some staphylococcal strains related to orthopaedic prosthesis infections by Sadovskaya, Irina, Chaignon, Philippe, Kogan, Grigorij, Chokr, Ali, Vinogradov, Evgeny, Jabbouri, Saïd

“…The capacity of coagulase‐negative staphylococci to colonize implanted medical devices is generally attributed to their ability to produce biofilms. Biofilm of…”
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Isoprenoidbiosynthese in pathogenen Bakterien: Nukleare inelastische Streuung ermöglicht Einblicke in den ungewöhnlichen [4Fe-4S]-Cluster vom E.-coli-Protein LytB/IspH by Faus, Isabelle, Reinhard, Annegret, Rackwitz, Sergej, Wolny, Juliusz A., Schlage, Kai, Wille, Hans-Christian, Chumakov, Aleksandr, Krasutsky, Sergiy, Chaignon, Philippe, Poulter, C. Dale, Seemann, Myriam, Schünemann, Volker

“…Abstract Das Protein LytB/ISPH katalysiert den letzten Schritt des Methylerythritolphosphat(MEP)‐Wegs, der zur Terpenoidbiosynthese in vielen pathogenen…”
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