Search Results - "Chai, Sophia"

Inflammatory memory sensitizes skin epithelial stem cells to tissue damage by Naik, Shruti, Larsen, Samantha B., Gomez, Nicholas C., Alaverdyan, Kirill, Sendoel, Ataman, Yuan, Shaopeng, Polak, Lisa, Kulukian, Anita, Chai, Sophia, Fuchs, Elaine

“…The skin barrier is the body’s first line of defence against environmental assaults, and is maintained by epithelial stem cells (EpSCs). Despite the…”
Get full text

A Role for the Primary Cilium in Notch Signaling and Epidermal Differentiation during Skin Development by Ezratty, Ellen J., Stokes, Nicole, Chai, Sophia, Shah, Alok S., Williams, Scott E., Fuchs, Elaine

“…Ciliogenesis precedes lineage-determining signaling in skin development. To understand why, we performed shRNA-mediated knockdown of seven intraflagellar…”
Get full text

Wdr1-mediated cell shape dynamics and cortical tension are essential for epidermal planar cell polarity by Luxenburg, Chen, Heller, Evan, Pasolli, H. Amalia, Chai, Sophia, Nikolova, Maria, Stokes, Nicole, Fuchs, Elaine

“…During mouse development, core planar cell polarity (PCP) proteins become polarized in the epidermal plane to guide angling/morphogenesis of hair follicles…”
Get full text

Author Correction: Inflammatory memory sensitizes skin epithelial stem cells to tissue damage by Naik, Shruti, Larsen, Samantha B., Gomez, Nicholas C., Alaverdyan, Kirill, Sendoel, Ataman, Yuan, Shaopeng, Polak, Lisa, Kulukian, Anita, Chai, Sophia, Fuchs, Elaine

“…In Fig. 2g of this Article, a panel was inadvertently duplicated. The ‘D30 IMQ’ image was a duplicate of the ‘D6 Ctrl’ image. Fig. 2g has been corrected online…”
Get full text

IL-15 Receptor Maintains Lymphoid Homeostasis by Supporting Lymphocyte Homing and Proliferation by Lodolce, James P, Boone, David L, Chai, Sophia, Swain, Rachel E, Dassopoulos, Themistocles, Trettin, Shanthi, Ma, Averil

“…The IL-15 receptor alpha subunit (IL-15Rα) mediates high-affinity binding of IL-15, a pleiotropic cytokine implicated in the development of innate immune…”
Get full text

IL-15Rα Expression on CD8+T Cells Is Dispensable for T Cell Memory by Burkett, Patrick R., Koka, Rima, Chien, Marcia, Chai, Sophia, Chan, Faye, Ma, Averil, Boone, David L.

“…The generation and maintenance of immunological memory requires the activation, expansion, and persistent proliferation of antigen-specific T cells. Recent…”
Get full text

Interleukin-15 and the regulation of lymphoid homeostasis by Lodolce, James, Burkett, Patrick, Koka, Rima, Boone, David, Chien, Marcia, Chan, Faye, Madonia, Michelle, Chai, Sophia, Ma, Averil

“…Interleukin-15 (IL-15) is a cytokine that plays unique roles in both innate and adaptive immune cell homeostasis. While early studies suggested that IL-15…”
Get full text

ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development by Woo, Tammy, Callahan, Joseph A, Ma, Averil, Turer, Emre E, Yen, Benjamin, Chai, Sophia, Oshima, Shigeru, Advincula, Rommel, Shifrin, Nataliya, Lee, Bettina, Malynn, Barbara A, Barrera, Julio

“…Proteins that directly regulate tumour necrosis factor receptor (TNFR) signalling have critical roles in regulating cellular activation and survival. ABIN-1…”
Get full text

Coordinate Expression and Trans Presentation of Interleukin (IL)-15Rα and IL-15 Supports Natural Killer Cell and Memory CD8+ T Cell Homeostasis by Burkett, Patrick R., Koka, Rima, Chien, Marcia, Chai, Sophia, Boone, David L., Ma, Averil

“…The high affinity interleukin (IL)-15 receptor, IL-15Rα, is essential for supporting lymphoid homeostasis. To assess whether IL-15Rα's role in vivo is to trans…”
Get full text

Failure to Regulate TNF-Induced NF-κB and Cell Death Responses in A20-Deficient Mice by Lee, Eric G., Boone, David L., Chai, Sophia, Libby, Shon L., Chien, Marcia, Lodolce, James P., Ma, Averil

“…A20 is a cytoplasmic zinc finger protein that inhibits nuclear factor κB (NF-κB) activity and tumor necrosis factor (TNF)-mediated programmed cell death (PCD)…”
Get full text

Cutting edge: murine dendritic cells require IL-15R alpha to prime NK cells by Koka, Rima, Burkett, Patrick, Chien, Marcia, Chai, Sophia, Boone, David L, Ma, Averil

“…NK cells protect hosts against viral pathogens and transformed cells, and dendritic cells (DCs) play important roles in activating NK cells. We now find that…”
Get full text

Interleukin (IL)-15Rα–deficient Natural Killer Cells Survive in Normal but Not IL-15Rα–deficient Mice by Koka, Rima, Burkett, Patrick R., Chien, Marcia, Chai, Sophia, Chan, Faye, Lodolce, James P., Boone, David L., Ma, Averil

“…Natural killer (NK) cells protect hosts against viral pathogens and transformed cells. IL-15 is thought to play a critical role in NK cell development, but its…”
Get full text

The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses by Ma, Averil, Boone, David L, Turer, Emre E, Lee, Eric G, Ahmad, Regina-Celeste, Wheeler, Matthew T, Tsui, Colleen, Hurley, Paula, Chien, Marcia, Chai, Sophia, Hitotsumatsu, Osamu, McNally, Elizabeth, Pickart, Cecile

“…A20 is a cytoplasmic protein required for the termination of tumor necrosis factor (TNF)-induced signals. We show here that mice doubly deficient in either A20…”
Get full text

ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development by Oshima, Shigeru, Turer, Emre E, Callahan, Joseph A, Chai, Sophia, Advincula, Rommel, Barrera, Julio, Shifrin, Nataliya, Lee, Bettina, Yen, T. S. Benedict, Woo, Tammy, Malynn, Barbara A, Ma, Averil

Get full text

Erratum: ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development by Oshima, Shigeru, Turer, Emre E., Callahan, Joseph A., Chai, Sophia, Advincula, Rommel, Barrera, Julio, Shifrin, Nataliya, Lee, Bettina, Yen, T. S. Benedict, Woo, Tammy, Malynn, Barbara A., Ma, Averil

“…Nature 457, 906–909 (2009) In this Letter, the name of T. S. Benedict Yen was incorrectly listed as Benjamin Yen. This author is affiliated with the Pathology…”
Get full text

IL-15Ralpha expression on CD8+ T cells is dispensable for T cell memory by Burkett, Patrick R, Koka, Rima, Chien, Marcia, Chai, Sophia

“…The generation and maintenance of immunological memory requires the activation, expansion, and persistent proliferation of antigen-specific T cells. Recent…”
Get full text

Coordinate expression and trans presentation of interleukin (IL)-15Ralpha and IL-15 supports natural killer cell and memory CD8+ T cell homeostasis by Burkett, Patrick R, Koka, Rima, Chien, Marcia, Chai, Sophia, Boone, David L, Ma, Averil

“…The high affinity interleukin (IL)-15 receptor, IL-15Ralpha, is essential for supporting lymphoid homeostasis. To assess whether IL-15Ralpha's role in vivo is…”
Get full text

Coordinate Expression and Trans Presentation of Interleukin (IL)-15R alpha and IL-15 Supports Natural Killer Cell and Memory CD8 super(+) T Cell Homeostasis by Burkett, Patrick R, Koka, Rima, Chien, Marcia, Chai, Sophia, Boone, David L, Ma, Averil

“…The high affinity interleukin (IL)-15 receptor, IL-15R alpha , is essential for supporting lymphoid homeostasis. To assess whether IL-15R alpha 's role in vivo…”
Get full text

Murine Dendritic Cells Require IL-15R alpha to Prime NK Cells by Koka, Rima, Burkett, Patrick, Chien, Marcia, Chai, Sophia, Boone, David L, Ma, Averil

“…NK cells protect hosts against viral pathogens and transformed cells, and dendritic cells (DCs) play important roles in activating NK cells. We now find that…”
Get full text

Interleukin (IL)-15R[alpha]-deficient natural killer cells survive in normal but not IL-15R[alpha]-deficient mice by Koka, Rima, Burkett, Patrick R, Chien, Marcia, Chai, Sophia, Chan, Faye, Lodolce, James P, Boone, David L, Ma, Averil

“…Natural killer (NK) cells protect hosts against viral pathogens and transformed cells. IL-15 is thought to play a critical role in NK cell development, but its…”
Get full text