In Vitro Characterization of a Novel Human Acellular Dermal Matrix (BellaCell HD) for Breast Reconstruction

In Vitro Characterization of a Novel Human Acellular Dermal Matrix (BellaCell HD) for Breast Reconstruction

In the past, acellular dermal matrices (ADMs) have been used in implant-based breast reconstruction. Various factors affect the clinical performance of ADMs since there is a lack of systematic characterization of ADM tissues. This study used BellaCell HD and compared it to two commercially available...

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Bibliographic Details
Published in:Bioengineering (Basel) Vol. 7; no. 2; p. 39
Main Authors: Nam, Sun-Young, Youn, Dayoung, Kim, Gyeong Hoe, Chai, Ji Hwa, Lim, Hyang Ran, Jung, Hong Hee, Heo, Chan Yeong
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 28-04-2020
MDPI
Subjects:
acellular dermal matrix
AlloDerm RTU
BellaCell HD
Biocompatibility
Bioengineering
Biomedical materials
Breast
Carbon dioxide
Cell culture
Cell growth
Collagen
Cytotoxicity
DermACELL
Elongation
Fibroblasts
Growth factors
Load
Physiology
Stiffness
Studies
Sutures
Tensile strength
Toxicity
United States > US
DermACELL
acellular dermal matrix
AlloDerm RTU
BellaCell HD
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Summary:In the past, acellular dermal matrices (ADMs) have been used in implant-based breast reconstruction. Various factors affect the clinical performance of ADMs since there is a lack of systematic characterization of ADM tissues. This study used BellaCell HD and compared it to two commercially available ADMs-AlloDerm Ready to Use (RTU) and DermACELL-under in vitro settings. Every ADM was characterized to examine compatibility through cell cytotoxicity, proliferation, and physical features like tensile strength, stiffness, and the suture tensile strength. The BellaCell HD displayed complete decellularization in comparison with the other two ADMs. Several fibroblasts grew in the BellaCell HD with no cytotoxicity. The proliferation level of fibroblasts in the BellaCell HD was higher, compared to the AlloDerm RTU and DermACELL, after 7 and 14 days. The BellaCell HD had a load value of 444.94 N, 22.44 tensile strength, and 118.41% elongation ratio, and they were higher than in the other two ADMs. There was no significant discrepancy in the findings of stiffness evaluation and suture retention strength test. The study had some limitations because there were many other more factors useful in ADM's testing. In the study, BellaCell HD showed complete decellularization, high biocompatibility, low cytotoxicity, high tensile strength, high elongation, and high suture retention strengths. These characteristics make BellaCell HD a suitable tissue for adequate and safe use in implant-based breast reconstruction in humans.
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ISSN:2306-5354
2306-5354
DOI:10.3390/bioengineering7020039