Search Results - "Chai, Anping"
-
1
Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42
Published in Nature communications (09-06-2023)“…ClC-2 transports chloride ions across plasma membranes and plays critical roles in cellular homeostasis. Its dysfunction is involved in diseases including…”
Get full text
Journal Article -
2
Synaptic P-Rex1 signaling regulates hippocampal long-term depression and autism-like social behavior
Published in Proceedings of the National Academy of Sciences - PNAS (15-12-2015)“…Autism spectrum disorders (ASDs) are a group of highly inheritable mental disorders associated with synaptic dysfunction, but the underlying cellular and…”
Get full text
Journal Article -
3
The epilepsy and intellectual disability-associated protein TBC1D24 regulates the maintenance of excitatory synapses and animal behaviors
Published in PLoS genetics (31-01-2020)“…Perturbation of synapse development underlies many inherited neurodevelopmental disorders including intellectual disability (ID). Diverse mutations on the…”
Get full text
Journal Article -
4
Chronic clomipramine treatment reverses core symptom of depression in subordinate tree shrews
Published in PloS one (02-12-2013)“…Chronic stress is the major cause of clinical depression. The behavioral signs of depression, including anhedonia, learning and memory deficits, and sleep…”
Get full text
Journal Article -
5
Inhibition of Rac1 activity in the hippocampus impaired extinction of contextual fear
Published in Neuropharmacology (01-10-2016)“…Promoting extinction of fear memory is the main treatment of fear disorders, especially post-traumatic stress disorder (PTSD). However, fear extinction is…”
Get full text
Journal Article -
6
The selective dopamine D1 receptor agonist SKF81297 modulates NMDA receptor currents independently of D1 receptors
Published in Neuropharmacology (01-04-2022)“…Dopamine D1 receptor (D1R) agonists are frequently used to study the role of D1Rs in neurotransmission and behaviour. They have been repeatedly shown to…”
Get full text
Journal Article -
7
STON2 variations are involved in synaptic dysfunction and schizophrenia-like behaviors by regulating Syt1 trafficking
Published in Science bulletin (30-05-2024)“…[Display omitted] Synaptic dysfunction is a core component of the pathophysiology of schizophrenia. However, the genetic risk factors and molecular mechanisms…”
Get full text
Journal Article -
8
The selective dopamine D 1 receptor agonist SKF81297 modulates NMDA receptor currents independently of D 1 receptors
Published in Neuropharmacology (01-04-2022)“…Dopamine D receptor (D R) agonists are frequently used to study the role of D Rs in neurotransmission and behaviour. They have been repeatedly shown to…”
Get full text
Journal Article -
9
Chronic Clomipramine Treatment Reverses Core Symptom of Depression in Subordinate Tree Shrews: e80980
Published in PloS one (01-12-2013)“…Chronic stress is the major cause of clinical depression. The behavioral signs of depression, including anhedonia, learning and memory deficits, and sleep…”
Get full text
Journal Article