Search Results - "Chai, Amanda B."

Regulation of P-Glycoprotein in the Brain by Chai, Amanda B, Callaghan, Richard, Gelissen, Ingrid C

“…Maintenance of the tightly regulated homeostatic environment of the brain is facilitated by the blood-brain barrier (BBB). P-glycoprotein (P-gp), an…”
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Examining the role of ABC lipid transporters in pulmonary lipid homeostasis and inflammation by Chai, Amanda B, Ammit, Alaina J, Gelissen, Ingrid C

“…Respiratory diseases including asthma and chronic obstructive pulmonary disease (COPD) are characterised by excessive and persistent inflammation. Current…”
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The Ubiquitin E3 Ligase Nedd4 Regulates the Expression and Amyloid-β Peptide Export Activity of P-Glycoprotein by Chai, Amanda B, Callaghan, Richard, Gelissen, Ingrid C

“…The ATP-binding cassette transporter, P-glycoprotein (P-gp), has been demonstrated to facilitate the clearance of amyloid-beta (Aβ) peptides, exporting the…”
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New Evidence for P-gp-Mediated Export of Amyloid-β PEPTIDES in Molecular, Blood-Brain Barrier and Neuronal Models by Chai, Amanda B, Hartz, Anika M S, Gao, Xuexin, Yang, Alryel, Callaghan, Richard, Gelissen, Ingrid C

“…Defective clearance mechanisms lead to the accumulation of amyloid-beta (Aβ) peptides in the Alzheimer's brain. Though predominantly generated in neurons,…”
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P‐glycoprotein: a role in the export of amyloid‐β in Alzheimer's disease? by Chai, Amanda B., Leung, Gavin K. F., Callaghan, Richard, Gelissen, Ingrid C.

“…The accumulation of amyloid‐β (Aβ) peptides is a key histopathological feature of the Alzheimer's brain. Defective clearance mechanisms result in toxic levels…”
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Apolipoprotein E isoform-dependent effects on the processing of Alzheimer's amyloid-β by Chai, Amanda B., Lam, Hin Hei Julian, Kockx, Maaike, Gelissen, Ingrid C.

“…Since the identification of the apolipoprotein E (apoE) *ε4 allele as a major genetic risk factor for late-onset Alzheimer's disease, significant efforts have…”
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Balancing cholesterol in the brain: from synthesis to disposal by Lydia Qian, Amanda B. Chai, Ingrid C. Gelissen, Andrew J. Brown

“…The cholesterol is a vital component of cell membranes and myelin sheaths, and a precursor for essential molecules such as steroid hormones. In humans,…”
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