Search Results - "Chahal, Gurdeep"
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The Importance of Exosite Interactions for Substrate Cleavage by Human Thrombin
Published in PloS one (25-06-2015)“…Thrombin is a serine protease of the chymotrypsin family that acts both as a procoagulant and as an anticoagulant by cleaving either factor VIII, factor V and…”
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Duodenases are a small subfamily of ruminant intestinal serine proteases that have undergone a remarkable diversification in cleavage specificity
Published in PloS one (28-05-2021)“…Ruminants have a very complex digestive system adapted for the digestion of cellulose rich food. Gene duplications have been central in the process of adapting…”
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Extended Cleavage Specificity of Human Neutrophil Elastase, Human Proteinase 3, and Their Distant Ortholog Clawed Frog PR3-Three Elastases With Similar Primary but Different Extended Specificities and Stability
Published in Frontiers in immunology (16-10-2018)“…Serine proteases are major granule constituents of several of the human hematopoietic cell lineages. Four proteolytically active such proteases have been…”
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Extended cleavage specificity of human neutrophil cathepsin G: A low activity protease with dual chymase and tryptase-type specificities
Published in PloS one (13-04-2018)“…Human neutrophils express at least four active serine proteases, cathepsin G, N-elastase, proteinase 3 and neutrophil serine protease 4 (NSP4). They have all…”
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Helicobacter suis infection alters glycosylation and decreases the pathogen growth inhibiting effect and binding avidity of gastric mucins
Published in Mucosal immunology (01-05-2019)“…Helicobacter suis is the most prevalent non- Helicobacter pylori Helicobacter species in the human stomach and is associated with chronic gastritis, peptic…”
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Streptococcus oralis Employs Multiple Mechanisms of Salivary Mucin Binding That Differ Between Strains
Published in Frontiers in cellular and infection microbiology (17-06-2022)“…Streptococcus oralis is an oral commensal and opportunistic pathogen that can enter the bloodstream and cause bacteremia and infective endocarditis. Here, we…”
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Extended cleavage specificity of sheep mast cell protease-2: A classical chymase with preference to aromatic P1 substrate residues
Published in Developmental and comparative immunology (01-03-2019)“…Serine proteases constitute the major protein content of mammalian mast cell granules and the selectivity for substrates by these proteases is of major…”
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A Complex Connection Between the Diversity of Human Gastric Mucin O-Glycans, Helicobacter pylori Binding, Helicobacter Infection and Fucosylation
Published in Molecular & cellular proteomics (01-11-2022)“…Helicobacter pylori colonizes the stomach of half of the human population. Most H. pylori are located in the mucus layer, which is mainly comprised by…”
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